The Dosage and Action of Pituitary Extract and of the Ergot Alkaloids on the Uterus in Labour, with a note on the Action of Adrenalin.*

Bourne, Aleck; Burn, J. H.

doi:10.1111/j.1471-0528.1927.tb15992.x

Cited by 87 publications

(12 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While the drug was considered ‘physiological’ and therefore safe, the dosage was not standardised, and, like ergot extracts before it, caused the death of many women from uterine rupture and many fetuses from intrauterine asphyxia. It was not until almost halfway through the 20th century in 1948, that JH Burn, working under HH Dale, introduced the now well‐known method of administering the drug in extreme dilution by slow intravenous infusion . Around this time, the infusion of very low doses, the ‘physiological approach’, was pioneered by Theobald et al …”

Section: Introductionmentioning

confidence: 99%

“…It was not until almost halfway through the 20th century in 1948, that JH Burn, working under HH Dale, introduced the now well-known method of administering the drug in extreme dilution by slow intravenous infusion. 4 Around this time, the infusion of very low doses, the 'physiological approach', was pioneered by Theobald et al 5,6 Development of uterine activity: physiological considerations…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The use and abuse of oxytocin

Olàh

Steer

2015

The Obstetric & Gynaecologis

View full text Add to dashboard Cite

Key content Oxytocin is a well‐established drug with a long history of use. The generation of intrauterine pressure is a result of myometrial activity, but is attenuated by a softening cervix. The introduction of active management regimens have not changed the outcome of labour as we envisaged. Too many babies suffer asphyxia as a result of misuse of oxytocin. Some form of education programme must be developed to warn of the dangers of this very useful drug. Better training and education programmes must be in place for midwives and obstetricians for labour management and cardiotography interpretation. Learning objectives To outline the history of the development of oxytocin. To understand the mechanism of intrauterine pressure development. To understand the methods of intrauterine pressure measurement and assessment. To understand the development of principles of active management with a discussion of the subsequent studies analysing the results of such labour management. To outline the medicolegal aspects of labour augmentation, with particular reference to oxytocin use. To discuss possible implications for the future. Ethical issues Should all women be given the information that oxytocin augmentation of slow labour may reduce the duration of labour by several hours but does not change the mode of delivery, whilst carrying a risk of causing fetal asphyxia? Should women sign informed consent before their labours are augmented? Should augmentation of labour only be undertaken under the direct supervision of a senior clinician?

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The use and abuse of oxytocin

Olàh

Steer

2015

The Obstetric & Gynaecologis

View full text Add to dashboard Cite

show abstract

“…The Montevideo unit (MU, mean active pressure of contractions multiplied by frequency of contractions per 10 min, Caldeyro-Barcia et al 1957) was devised to combine both variables, but is difficult to quantitate automatically 'on-line'. An alternative is the measurement of active contraction area, which incorporates frequency, active pressure and duration of contractions (Bourne & Burn 1927;Caldeyro et al 1950). Using modern electronic techniques, active contraction area is much simpler to measure than MU (Woolfson et al 1976;Carter & Steer 1976;Steer & Carter 1977).…”

mentioning

confidence: 99%

Normal levels of active contraction area in spontaneous labour

Steer

Carter

Beard

1984

BJOG

View full text Add to dashboard Cite

A detailed study has been made of uterine activity in a group of 2 1 unselected women in spontaneous labour. Measurements were made of contraction frequency, active pressure, Montevideo units and active contraction area. The level of Montevideo units were comparable with values previously reported in spontaneous labour. Active contraction area correlated better than any of the other measures with the rate of cervical dilatation in the active phase of labour (r = 0.69). The mean contraction area was 1099 (SD 333) kPas/lS min.

show abstract

“…In the search for a more practical method of on-line quantitation of uterine activity, Hon and co-workers (Hon and Paul, 1973;Miller et al, 1976) returned to the planimetric technique first described by Bourne in 1927. Not only is the assessment difficult to make if uterine activity is incoordinate, but it is not practical for widespread clinical use "on line" because of its time-consuming nature.…”

Section: Analysis Of Intrauterine Pressure Readingsmentioning

confidence: 99%

Technical Aspects of Fetal and Intrauterine Pressure Monitoring

Steer

1984

Fetal Physiology and Medicine

View full text Add to dashboard Cite

The Dosage and Action of Pituitary Extract and of the Ergot Alkaloids on the Uterus in Labour, with a note on the Action of Adrenalin.*

Cited by 87 publications

References 4 publications

The use and abuse of oxytocin

The use and abuse of oxytocin

Normal levels of active contraction area in spontaneous labour

Technical Aspects of Fetal and Intrauterine Pressure Monitoring

Contact Info

Product

Resources

About