“…While the drug was considered ‘physiological’ and therefore safe, the dosage was not standardised, and, like ergot extracts before it, caused the death of many women from uterine rupture and many fetuses from intrauterine asphyxia. It was not until almost halfway through the 20th century in 1948, that JH Burn, working under HH Dale, introduced the now well‐known method of administering the drug in extreme dilution by slow intravenous infusion . Around this time, the infusion of very low doses, the ‘physiological approach’, was pioneered by Theobald et al …”