The dog mast cell tumour as a model to study the relationship between angiogenesis, mast cell density and tumour malignancy

Ranieri, Girolamo; Passantino, Letizia; Patruno, Rosa; Passantino, Giuseppe; Jirillo, Felicita; Catino, Annamaria; Mattioli, V.; Gadaleta, Cosmo Damiano; Ribatti, Doménico

doi:10.3892/or.10.5.1189

Cited by 35 publications

(44 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many authors correlate microvessel density and prognosis in human breast cancer (Leek, 2001). Recent studies have been shown similar results in veterinary medicine (Restucci et al, 2002).…”

Section: Resultssupporting

confidence: 70%

“…Several epidemiological, clinical, and experimental studies have demonstrated an association between chronic inflammation and cancer, in which inflammatory mediators contribute to the progression of the illness (Murdoch et al, 2008). According to Ranieri et al (2003) (Imada et al, 2000;Elpek et al, 2001;Weidner et al, 2001;Kashiwase et al, 2004). The contribution of mast cells to angiogenesis in human tumors is clear but not well established (Murdoch et al, 2008), in veterinary medicine, however, there is no study in the literature with this information.…”

Section: Introductionmentioning

confidence: 89%

“…The growth of newly formed vessels, or angiogenesis, represents an important step in tumor growth and progression in several human and animal tumors (Restucci et al, 2002;Ribatti et al, 2004). High levels of angiogenic factors associated with histological evidence of increased tumor neovascularization, by measurement of microvessel densities, are considered to have important prognostic value in human medicine for several solid tumors (Imada et al, 2000;Elpek et al, 2001;Ribatti et al, 2004, Paoloni andKhanna, 2008).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Mast cells and angiogenesis in canine mammary tumor

Lavalle¹,

Bertagnolli²,

Tavares³

et al. 2010

Arq. Bras. Med. Vet. Zootec.

View full text Add to dashboard Cite

The correlation between microvessel density and mast cells density in canine mammary tumors was studied. Sixty-five samples of canine mammary tumors, being 24 benign and 41 malignant, were analyzed. The routine Toluidine Blue staining method was used to assess the mast cells. To evaluate angiogenesis, the immunohistochemical expression of CD31 was assessed. There was no significant difference in either mast cells (P=0.44) or microvessel density (P=0.77) between malignant and benign tumors. A positive correlation was observed between microvessel density and mast cells (r=0.39; P=0.011) in malignant tumors. These results suggest that mast cells may play a role in canine mammary malignant tumors development, promoting angiogenesis, similar to some tumors described in the human species.Keywords: bitch, mammary gland, mast cells, microvessel density, neoplasms RESUMO Estimou-se a correlação entre a densidade de microvasos e a densidade de mastócitos em tumores mamários caninos. Sessenta e cinco amostras de tumores mamários caninos

show abstract

“…Many authors correlate microvessel density and prognosis in human breast cancer (Leek, 2001). Recent studies have been shown similar results in veterinary medicine (Restucci et al, 2002).…”

Section: Resultssupporting

confidence: 70%

Section: Introductionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Mast cells and angiogenesis in canine mammary tumor

Lavalle¹,

Bertagnolli²,

Tavares³

et al. 2010

Arq. Bras. Med. Vet. Zootec.

View full text Add to dashboard Cite

show abstract

“…The low specificity of this antibody against vWF has been indicated in human soft tissue tumors. 19 The antibody against vWF has been used in several studies of angiogenesis in human cancer; 2,67,75 but on the contrary, there are a limited number of studies in canine tumors where vWF has been used as an endothelial marker, 9,10,40,50,51,79 including canine mammary tumors. 23,24 Regarding the rest of the endothelial markers studied, some ELCs of a single case were slightly positive of CD31; in all samples, ELCs were negative of CD34.…”

Section: Discussionmentioning

confidence: 99%

Histological, Immunohistological, and Ultrastructural Description of Vasculogenic Mimicry in Canine Mammary Cancer

et al. 2009

View full text Add to dashboard Cite

Canine inflammatory mammary cancer (IMC) and human inflammatory breast cancer (IBC) are the most aggressive and lethal type of mammary cancer in female dogs and in women. The generation of microvascular channels by malignant tumor cells (endothelial-like cells [ELCs]) without endothelial cell participation (vasculogenic mimicry) has been reported in human breast cancer, including IBC, and is considered a new type of tumor angiogenesis. The aim of this study was to investigate the presence of ELCs in highly malignant canine mammary tumors (IMC and non-IMC) by histology, inmunohistochemistry (pancytokeratin, cytokeratin 14, vimentin, actin, desmin, vWF, CD31, and CD34), and electron microscopy. This retrospective study included 21 female dogs with diagnoses of IMC and 20 animals with metastatic grade III noninflammatory malignant mammary tumors (MMT). IMC tumors (33.33%) and MMT (5%) showed ELCs forming structures similar to small capillaries. The histological, immunohistochemical (positive to AE1/AE3 and cytokeratin 14, mostly negative to endothelial markers), and ultrastructural characteristics of these cells indicated vasculogenic mimicry. The higher frequency of this phenomenon in inflammatory versus noninflammatory canine mammary cancer is in agreement with previous studies in experimental and spontaneous human IBC, and it could be in relation with the extremely high lymphangiogenic capacity and metastatic lymphangiotropism characteristics of inflammatory breast cancer.

show abstract

“…Evidence for a specific role for MCs has been reported in animal and human cancers, such as mast cell tumors, head and neck, gastric, lung and cutaneous malignancies, where MCs density is highly correlated with the extent of tumor angiogenesis (14)(15)(16)(17)(18).…”

Section: Introductionmentioning

confidence: 99%

Tryptase-positive mast cells correlate with angiogenesis in early breast cancer patients

et al. 2009

View full text Add to dashboard Cite

Abstract. Literature data indicate that mast cells (MCs) are involved in tumor angiogenesis due to the release of several pro-angiogenetic factors among which tryptase, a serine protease stored in MCs granules, is one of the most active. However, no data are available concerning the role of MCs in angiogenesis in primary human breast cancer. In this study, we have evaluated the correlations between the number of MCs positive to tryptase (MCDPT), the area occupied by MCs positive to tryptase (MCAPT) and microvascular density (MVD) and endothelial area (EA) in a series of 88 primary T1-3, N0-2 M0 female breast cancer, by means of immunohistochemistry and image analysis methods. Data demonstrated a significant (r = from 0.78 to 0.89; p-value from 0.001 to 0.002 by Pearson's analysis respectively) correlation between MCDPT, MCAPT, MVD, EA to each other. No correlation concerning MCDPT, MCAPT, MVD, EA and the main clinicopathological features was found. Our results suggest that tryptase-positive MCs play a role in breast cancer angiogenesis. In this context several tryptase inhibitors such as gabexate mesilate and nafamostat mesilate might be evaluated in clinical trials as a new anti-angiogenetic approach.

show abstract

The dog mast cell tumour as a model to study the relationship between angiogenesis, mast cell density and tumour malignancy

Cited by 35 publications

References 0 publications

Mast cells and angiogenesis in canine mammary tumor

Mast cells and angiogenesis in canine mammary tumor

Histological, Immunohistological, and Ultrastructural Description of Vasculogenic Mimicry in Canine Mammary Cancer

Tryptase-positive mast cells correlate with angiogenesis in early breast cancer patients

Contact Info

Product

Resources

About