The DNMT3B -579 G&gt;T promoter polymorphism and risk of lung cancer

Liu, Hui; Jiao, Yifei; Guan, Yuanyuan; Lao, Yingbin; Zhao, Chengcheng; Fan, Hong

doi:10.3892/etm.2011.420

Cited by 10 publications

(12 citation statements)

References 35 publications

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“…20,27 However, the results of the present study were different from those observed in other Asian populations with a higher frequency of T allele than G allele for DNMT3B-579G>T polymorphism. 23,24,33 The dissimilarity between the ethnicity and size of samples might be causes for the differences of allele and genotype distribution shown in the current study from those reported in previous investigations.…”

Section: Discussioncontrasting

confidence: 65%

“…Individuals with TT genotype indicated a higher risk of lung and colorectal cancers compared to those who had other genotypes. 24,25 Also, DNMT3B-579G>T did not show a significant association with Head and neck squamous cell carcinoma (HNSCC) in non-Hispanic whites. However, TT genotype of this polymorphism was linked to the increased risk of SCCHN when -579G>T was analyzed in combination with the other polymorphism of DNMT3B (-149C>T; rs2424913).…”

Section: Discussionmentioning

confidence: 95%

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DNMT3B-579G>T (rs1569686G>T) polymorphism and the risk of multiple sclerosis in a subset of Iranian population

Yazdanpanahi

Etemadifar

Shams

2019

CJN

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Background: Deoxyribonucleic acid (DNA) methyltransferase 3 beta (DNMT3B) gene encodes an MT enzyme involving in de novo methylation of DNA. The present investigation aimed to explore the association of DNMT3B-579G>T (rs1569686) polymorphism with multiple sclerosis (MS). Methods: 130 Iranian patients with MS and 130 controls were genotyped for the DNMT3B-579G>T using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: There was no statistically significant association between DNMT3B-579G>T and susceptibility to MS. The alleles and genotypes of DNMT3B-579G>T did not have different risks of MS development under various models [T vs. G (P = 0.86); GTvs. GG (P = 0.48); TT vs. GG (P > 0.99); GT+TT vs. GG (P = 0.60), and TT vs. GG+GT (P = 0.87)]. Also, there was no statistically significant association between genotypes and clinical and demographic characteristics of patients (P > 0.05). Conclusion: The current findings suggest that DNMT3B-579G>T is probably not a crucial potential risk marker in molecular diagnostics of MS among Iranian. However, to the best of our knowledge, this is the ﬁrst genetic association study about the DNMT3B polymorphisms and MS. Therefore, further surveys should be included to estimate the exact relevance of DNMT3B gene to the development of autoimmune disorders like MS.

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Section: Discussioncontrasting

confidence: 65%

Section: Discussionmentioning

confidence: 95%

DNMT3B-579G>T (rs1569686G>T) polymorphism and the risk of multiple sclerosis in a subset of Iranian population

Yazdanpanahi

Etemadifar

Shams

2019

CJN

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“…An opposite conclusion was found for an association between the DNMT3B ‐579G>T polymorphism and various cancers (Fan et al, 2008a). For example a significant decreased risk for colorectal cancer and lung cancer was observed for carriers of the ‐579 GT genotype (Liu et al, ). The DNMT3B ‐149T allele was shown to be associated with an increased activity (Shen et al, ) and a higher expression of the DNMT3B protein in carriers of the ‐149CT genotype (Fonseca‐Silva et al, ).…”

Section: Discussionmentioning

confidence: 99%

Maternal risk for down syndrome and polymorphisms in the promoter region of the DNMT3B gene: A case–control study

Jaiswal

Sukla

Kumari³

et al. 2015

Birth Defects Research

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“…Previous studies have demonstrated that the G allele significantly decreased the susceptibility to lung and colon cancer in a Korean population [29,30] and that the GT genotype was associated with a significantly decreased risk for lung cancer (OR: 0.517; 95% CI: 0.273-0.981) compared to the TT genotype in Northern and Southern Chinese populations [31]. However, it was also reported that there was no association between rs1569686 and head and neck squamous cell carcinoma in a Chinese population [32].…”

Section: Discussionmentioning

confidence: 99%

Association between DNA Methyltransferases 3B Gene Polymorphisms and the Susceptibility to Acute Myeloid Leukemia in Chinese Han Population

et al. 2013

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DNMT3B plays a crucial role in the generation of aberrant methylation during carcinogenesis. Polymorphisms in the DNMT3B gene may influence the DNA methylation enzymatic activity of DNMT3B, thereby modulating the susceptibility to AML. Thus, we investigated the association between SNPs in the DNMT3Bgene and their haplotypes with the risk of AML in the Chinese Han population. The DNMT3B genotype was determined by HRM in 317 de novo AML patients and 406 healthy control subjects matched for age and gender. Among the 5 SNPs investigated in this study, rs2424913 demonstrated no polymorphisms in the Chinese Han populations, rs1569686 and rs2424908 were significantly associated with AML risk. The GG genotype of rs1569686 was associated with increased AML risk (OR: 5.76; 95%CI: 2.60-12.73; P<0.01) compared with the TT genotype, and individuals with a G allele had a significantly increased risk (OR: 1.89; 95%CI: 1.41-2.52; P<0.01) for AML compared with those harboring a C allele, this polymorphism can predict the risk of AML in a minority of patients. While the CC genotype of rs2424908 appeared to reduce the AML risk (OR: 0.57; 95%CI: 0.36-0.91; P=0.01) compared with the TT genotype, individuals with a C allele were associated with a lower risk (OR: 0.79, 95%CI: 0.64-0.97, P=0.03) for developing AML compared with those harboring a T allele. The other 2 SNPs, rs6087990 and rs6119954, had no significant association with AML risk in the study population. The CGGT, CTAT, TGAT, and CGAT haplotypes of rs6087990, rs1569686, rs6119954, and rs2424908 appeared to significantly increase the AML risk, and the TTGC haplotype appeared to significantly reduce the risk. These results suggest that DNMT3B polymorphisms may contribute to the genetic susceptibility to AML; in particular, the G allele of rs1569686 serves as a risk factor for AML, whereas the C allele of rs2424908 represents a potential protective factor.

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The DNMT3B -579 G>T promoter polymorphism and risk of lung cancer

Cited by 10 publications

References 35 publications

DNMT3B-579G>T (rs1569686G>T) polymorphism and the risk of multiple sclerosis in a subset of Iranian population

DNMT3B-579G>T (rs1569686G>T) polymorphism and the risk of multiple sclerosis in a subset of Iranian population

Maternal risk for down syndrome and polymorphisms in the promoter region of the DNMT3B gene: A case–control study

Association between DNA Methyltransferases 3B Gene Polymorphisms and the Susceptibility to Acute Myeloid Leukemia in Chinese Han Population

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