Background Primary cardiac tumors are rare with an incidence of 0.0013 and 0.03% in collected autopsy series. 75% of primary cardiac tumors are benign. In adults 50% of benign cardiac tumors are myxomas. This report summarizes our 22 year experience with cardiac myxomas. Aim of our study was to analyse the presentation of myxoma and review the short and long term outcome after myxoma excision. Methods During the years 1986 to 2007, 32 patients were operated for myxoma.13 male (40.7%) and 19 female (59.3%) within an age range of 16 to 72 years, underwent surgical excision of primary or recurrent intra cardiac tumors. Seven patients (21.87%) presented with obstructive symptoms and 12 patients (37.55%) with embolic manifestations. In the embolic group, five patients (41.6%) had peripheral artery embolism and six (50%) had a cerebrovascular event and one presented with Left Pulmonary Artery embolism (8.33%). Twenty two patients (72.2%) had left atrial myxoma, eight patients (22.2%) had right atrial myxomas and two patients (5.5%) had biatrial myxomas. Two of the left atrial myxomas (6.25%) were recurrent lesion. The Surgical management was complete wide excision on Cardio pulmonary bypass. Results There were no early deaths. Twenty seven patients are on regular follow-up in class I symptoms with no documented recurrences. Conclusion Obstructive symptoms is the common mode of presentation followed by embolic manifestation. Transthoracic echocardiography, supplemented by trans esophageal echocardiography when necessary forms the mainstay of diagnosis. Surgical excision of atrial myxoma gives excellent short term and long term results.