The distribution of the Rh(D) blood types in Japan

Evaluation of a blood group genotyping platform (BLOODchip® Reference) in Japanese samples

“…In this study, up to 751 genotyping analyses were performed on 100 blood specimens of Japanese donors. Blood groups distribution was in accordance with what could be expected in a representative sample of the Japanese population (Fujita et al , 1978a,b; Kamatani et al , ). A high concordance between systems (98%) was obtained.…”

A genome-wide association study identifies two susceptibility loci for duodenal ulcer in the Japanese population

“…An analysis of 94 subjects showed that the T allele of rs505922 was in strong linkage disequilibrium (LD; r 2 = 0.97) with the ABO gene encoding the O blood type, which produces non functional protein due to a singlenucleotide deletion in codon 87 (rs8176719), concordant with a previous report 27 . By using the geno typing results of two tagging SNPs, through which ABO alleles can be inferred (rs505922 and rs8176746; Supplementary Table 9) 27 , we could successfully determine the ABO blood type in 98.6% of samples 28 (Supplementary Table 10). Association analysis showed that individuals with blood type O exhibited significantly higher risk for duodenal ulcer than those with blood type A (P = 2.04 × 10 −6 ; OR = 1.43; Supplementary Table 10).…”

Current status of percutaneous umbilical cord blood sampling in Japan

“…Red‐cell alloimmune disorder was the second most common cause of fetal anemia, including anti‐D alloimmunization in addition to other red cell antigens such as anti‐C, c, E, e or Kell. Rh D negative population is very small in Japan, representing approximately 0.5%, and the increased use of antenatal or postnatal prophylaxis with Rh immunoglobulin among females has led to a decreased incidence of fetal anemia due to red‐cell alloimmune disorders . Vaccination for parvovirus B19 is still not available, and almost half of the reproductive age female population is seronegative for parvovirus B19 in Japan.…”