The distribution of Ancylostoma caninum larvae in the central nervous system of the mouse infected with single or repeated doses

Abstract

The distribution of Ancylostoma caninum larvae in the various regions of the central nervous system of mice of previously uninfected or reinfected groups was studied. Although a dose of 4000 larvae was lethal, the distribution of larvae was not appreciable in the CNS. Many larvae were recovered from the cerebral hemispheres and cerebellum of infected mice whereas no incidence of eye involvement was observed in any mouse. In the reinfected mice groups there was a much lower recovery than in the previously uninfected groups in the latent period of study.

Experimental infection of pups with Ancylostoma caninum larvae from an abnormal host, the chicken

“…Migration into different tissues was at a peak between 12 and 36 hours after infection and thereafter sharply declined. In contrast to mice (NICHOLS, 1956;BHOPALE & JOHRI, 1978), no migration of larvae into the spleen, kidney and brain of the chickens was observed at any time in this study. The concentration of larvae in the muscles reached a maximum at 30 to 36 hours and then declined sharply from 36 to 72 hours.…”

Efficacy of various anthelmintics against third-stage larvae of Ancylostoma caninum in the brain of mice

“…Larvae of an unknown species of hookworm have been reported in the human cornea (BALDONE et al, 1964;NADBATH & LAWLOR, 1965). In experimental infections, A. caninum larvae migrate through the intestine, liver, lungs and ultimately the muscles and brain of mice after oral infection (BHOPALE & JOHRI, 1978) and this may suggest a possible risk of such infection to man (BHOPALE & JOHRI, 1978).…”