The distribution of fibrosis in the left ventricle in congenital aortic stenosis and coarctation of the aorta.

Cheitlin, M.D.; Robinowitz, Max; McAllister, H A; Hoffman, Julien I.E.; Bharati, Saroja; Lev, Morris W.

doi:10.1161/01.cir.62.4.823

Cited by 62 publications

(29 citation statements)

References 8 publications

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“…Diffuse fibrosis is viewed as the common pathological pathway toward deterioration in myocardial function in various pathologies [36,37]. The two techniques commonly used in assessing diffuse fibrosis are myocardial T1 mapping and extracellular volume fraction (ECV) mapping [38].…”

Section: Myocardial Fibrosismentioning

confidence: 99%

Role of cardiac MRI and CT in Fontan circulation

Yeong

Loughborough

Hamilton

et al. 2017

J Congenit Heart Dis

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A Fontan circulation is a series of palliative surgical procedures, which result in the diversion of the systemic venous return into pulmonary arterial circulation without passing through a ventricle. It is one of the available surgical strategies for patients with cardiac defects that preclude a successful bi-ventricular repair, which encompass a range of complex anatomy. This surgical repair has gone through a series of modifications since the concept was introduced in 1971. Echocardiography remains a vital tool in assessing patients with Fontan circulations but its limitations are well recognised. Cross-sectional imaging modalities such as cardiac MRI and CT are essential components in the systematic clinical evaluation of these patients. The purpose of this review is to understand the information that can be obtained with each cross-sectional modality as well as highlight the challenges that each modality faces.

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Section: Myocardial Fibrosismentioning

confidence: 99%

Role of cardiac MRI and CT in Fontan circulation

Yeong

Loughborough

Hamilton

et al. 2017

J Congenit Heart Dis

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“…Essential changes in myocardial fibrosis in pressure-overload heart were observed in perivascular and interstitial fibrosis. At first, myocardial fibrosis occurred around the coronal vessels, and then progressed in the interstitial tissues [4,29,32]. Intermittent administration of sr-ISDN significantly suppressed in both the coronal vessels and interstitial tissues.…”

Section: Discussionmentioning

confidence: 96%

Effect of Intermittent Administration of Sustained Release Isosorbide Dinitrate (sr-ISDN) in Rats with Pressure-Overload Heart

Shimamura

Endo

Kutsuna

et al. 2006

The Journal of Veterinary Medical Science

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ABSTRACT. Recent studies have demonstrated the benefits of nitric oxide (NO) on myocardial hypertrophy and myocardial fibrosis. It was suggested that NO has a protective effect on myocardial cell through the neurohormonal system. This effect serves to highlight the important role of NO in maintaining the function and form of heart with chronic heart failure. However, there are no known reports about on the effect of prolonged administration of nitrate on pressure over-load heart. This study was conducted to examine the longterm effect of oral nitrate therapy in rats with pressure-overloaded heart. An abdominal aorta constricted (AC) model of pressure-overloaded heart was created in male Wistar rats. Sustained release isosorbide dinitrate (sr-ISDN) (5 mg/kg once a daily) was administered to the rats once a daily for 12 weeks. The animals were euthanized during the study period, and the heart was collected and weighed. Histopathological examination was performed to evaluate the effect of sr-ISDN on myocardial hypertrophy and fibrosis. The ratio of heart to body weight increased significantly in AC rat and this increase was significantly prevented by sr-ISDN treatment. Histopathological examination showed significant increase in fibrotic area of AC rat compared to sham rat, this increase was inhibited by sr-ISDN treatment. Cardiomyocyte transverse diameter was significantly increased in AC rat compared with sham rat, but this increase tended to decrease by sr-ISDN treatment. In conclusion, intermittent administration with sr-ISDN has mild effect in inhibiting cardiac hypertrophy and marked effect in inhibiting fibrosis due to pressure-overload. KEY WORDS: aortic constrict model, cardiac fibrosis, cardiac hypertrophy, isosorbide dinitrate, rat.

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“…1,7,10,11 Myocardial fibrosis manifests in the pressure-loaded left ventricle of infants and children with aortic stenosis and coarctation. 1 In patients with tetralogy of Fallot right ventricular myofiber disorganization and interstitial fibrosis have been demonstrated histologically. 2,12 Interestingly, right ventricular fibrosis not only occurs in late adult survivors, but is already present in infants with this condition.…”

Section: Pathogenesis and Clinical Relevance Of Diffuse Myocardial Fimentioning

confidence: 99%

“…Diffuse fibrosis is regarded to be the common pathological pathway toward loss of myocardial function in many cardiac conditions, including congenital heart disease. [1][2][3][4] As fibrosis seems to have a major role in myocardial failure and may be reversible, [5][6][7][8] its assessment by CMR has the potential to transform the way we monitor and treat our patients. 9 In this review, we describe the technical aspects of fibrosis quantification with CMR and outline past and potential applications in congenital and pediatric heart disease.…”

mentioning

confidence: 99%