Effect of Intermittent Administration of Sustained Release Isosorbide Dinitrate (sr-ISDN) in Rats with Pressure-Overload Heart

Shimamura, Shunsuke; Endo, Hidehiko; Kutsuna, Hiromi; Kobayashi, Masayuki; Hirao, Hidehiro; Shimizu, Miki; Tanaka, Ryou; Yamane, Yoshihisa

doi:10.1292/jvms.68.213

Cited by 2 publications

(1 citation statement)

References 55 publications

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“…Several characteristics of maladaptive RV remodeling in the PAH model have been proposed, including RV dilation, reduced function, fibrosis, and capillary rarefication ( 29 , 150 ). However, as of the confounding effects of potentially altered pulmonary vascular resistance, hypoxia, molecular modulation (e.g., VEGF inhibition), or toxins on RV function, the MCT and SuHx models cannot be used to investigate isolated RV effects of potential therapies, and the PAB model is relevant in this regard ( 29 , 151 , 152 ).…”

Section: Surgical Modelsmentioning

confidence: 99%

A review on experimental surgical models and anesthetic protocols of heart failure in rats

et al. 2023

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Heart failure (HF) is a serious health and economic burden worldwide, and its prevalence is continuously increasing. Current medications effectively moderate the progression of symptoms, and there is a need for novel preventative and reparative treatments. The development of novel HF treatments requires the testing of potential therapeutic procedures in appropriate animal models of HF. During the past decades, murine models have been extensively used in fundamental and translational research studies to better understand the pathophysiological mechanisms of HF and develop more effective methods to prevent and control congestive HF. Proper surgical approaches and anesthetic protocols are the first steps in creating these models, and each successful approach requires a proper anesthetic protocol that maintains good recovery and high survival rates after surgery. However, each protocol may have shortcomings that limit the study's outcomes. In addition, the ethical regulations of animal welfare in certain countries prohibit the use of specific anesthetic agents, which are widely used to establish animal models. This review summarizes the most common and recent surgical models of HF and the anesthetic protocols used in rat models. We will highlight the surgical approach of each model, the use of anesthesia, and the limitations of the model in the study of the pathophysiology and therapeutic basis of common cardiovascular diseases.

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Section: Surgical Modelsmentioning

confidence: 99%

A review on experimental surgical models and anesthetic protocols of heart failure in rats

et al. 2023

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Effect of sodium houttuyfonate on inhibiting ventricular remodeling induced by abdominal aortic banding in rats

Gao

Chen

et al. 2010

Can. J. Physiol. Pharmacol.

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Ventricular remodeling is an independent risk factor for many cardiovascular events. Inhibiting ventricular remodeling early may be an effective way to postpone heart failure for patients with cardiovascular illness. The study was designed to examine the effect of sodium houttuyfonate on ventricular remodeling induced by pressure overload in rats, as well as to explore the mechanisms involved. The model rats in which ventricular remodeling was induced abdominal aortic banding (AAB) were randomly divided into 4 groups: AAB control, AAB plus captopril (40 mg/kg), AAB plus low dose of sodium houttuyfonate (50 mg/kg), and AAB plus high dose of sodium houttuyfonate (100 mg/kg). One month after operation, hemodynamic parameters, heart mass indexes, size of cardiomyocytes, myocardial collagen volume, angiotensin II content in ventricular tissue, and serum concentrations of aldosterone and tumor necrosis factor (TNF)-alpha were evaluated. Sodium houttuyfonate significantly reduced heart mass indexes, the size of cardiomyocytes, and the myocardial collagen volume and decreased the levels of angiotensin II, aldosterone, and TNF-alpha. At the high dose, it decreased blood pressure and heart rate. In conclusion, sodium houttuyfonate attenuates ventricular remodeling induced by pressure overload in rats. The beneficial effects are in part associated with its alleviating the activation of renin-angiotensin-aldosterone system and decreasing the TNF-alpha level. Furthermore, its function seems to correlate with reduced blood pressure and heart rate.

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Effect of Intermittent Administration of Sustained Release Isosorbide Dinitrate (sr-ISDN) in Rats with Pressure-Overload Heart

Cited by 2 publications

References 55 publications

A review on experimental surgical models and anesthetic protocols of heart failure in rats

A review on experimental surgical models and anesthetic protocols of heart failure in rats

Effect of sodium houttuyfonate on inhibiting ventricular remodeling induced by abdominal aortic banding in rats

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