Effect of sodium houttuyfonate on inhibiting ventricular remodeling induced by abdominal aortic banding in rats

Abstract

Ventricular remodeling is an independent risk factor for many cardiovascular events. Inhibiting ventricular remodeling early may be an effective way to postpone heart failure for patients with cardiovascular illness. The study was designed to examine the effect of sodium houttuyfonate on ventricular remodeling induced by pressure overload in rats, as well as to explore the mechanisms involved. The model rats in which ventricular remodeling was induced abdominal aortic banding (AAB) were randomly divided into 4 groups: AAB control, AAB plus captopril (40 mg/kg), AAB plus low dose of sodium houttuyfonate (50 mg/kg), and AAB plus high dose of sodium houttuyfonate (100 mg/kg). One month after operation, hemodynamic parameters, heart mass indexes, size of cardiomyocytes, myocardial collagen volume, angiotensin II content in ventricular tissue, and serum concentrations of aldosterone and tumor necrosis factor (TNF)-alpha were evaluated. Sodium houttuyfonate significantly reduced heart mass indexes, the size of cardiomyocytes, and the myocardial collagen volume and decreased the levels of angiotensin II, aldosterone, and TNF-alpha. At the high dose, it decreased blood pressure and heart rate. In conclusion, sodium houttuyfonate attenuates ventricular remodeling induced by pressure overload in rats. The beneficial effects are in part associated with its alleviating the activation of renin-angiotensin-aldosterone system and decreasing the TNF-alpha level. Furthermore, its function seems to correlate with reduced blood pressure and heart rate.

Sodium Houttuyfonate Inhibits Voltage-Gated Peak Sodium Current and Anemonia Sulcata Toxin II-Increased Late Sodium Current in Rabbit Ventricular Myocytes

“…From the findings mentioned above, we speculated that increased I Na.L may partly participate in the pathogenesis of myocardial hypertrophy and ventricular remodeling. Furthermore, experimental studies revealed that SH inhibited myocardial hypertrophy and attenuated ventricular remodeling [5,6]. Thus, the alleviative effects of myocardial hypertrophy and ventricular remodeling by SH may be related to the inhibition of increased I Na.L .…”

“…f The concentration-response relationship curve for the effects of SH on I Na.P , fitted to the Hill equation. Discussion SH, a chemical compound originating from the Chinese herb Houttuynia cordata, was reported to have antibacterial and antifungal effects, as well as cardioprotective effects [1][2][3][4][5][6]. However, the effects of SH on cardiac electrophysiology remain unknown.…”

“…In addition to its antibacterial and antifungal effects, SH was also reported to be a cardioprotective compound. Experimental studies demonstrated that SH inhibited myocardial hypertrophy and attenuated ventricular remodeling [5,6]. The function of the heart is closely associated with the activity of sodium channels in cardiomyocytes.…”

Sodium houttuyfonate affects production of N-acyl homoserine lactone and quorum sensing-regulated genes expression in Pseudomonas aeruginosa

“…Houttuynia cordata Thunb (Saururaceae family) is an edible plant used in traditional Chinese medicine for the treatment of a wide range of infectious diseases, including pneumonia (Gao et al, 2009, 2010; Li et al, 2014). The major constituent of the volatile oil derived from H. cordata , sodium houttuyfonate [SH, CH 3 (CH 2 ) 8 COCH 2 CHOHSO 3 Na] is a product of the addition reaction of sodium bisulfite and houttuynin [i.e., decanoyl acetaldehyde, CH 3 (CH 2 ) 8 COCH 2 CHO] (Wang et al, 2002).…”

“…The major constituent of the volatile oil derived from H. cordata , sodium houttuyfonate [SH, CH 3 (CH 2 ) 8 COCH 2 CHOHSO 3 Na] is a product of the addition reaction of sodium bisulfite and houttuynin [i.e., decanoyl acetaldehyde, CH 3 (CH 2 ) 8 COCH 2 CHO] (Wang et al, 2002). SH is the active compound of the Houttuynia plant, the healing properties of which have been recorded in ancient Chinese medical writings (Gao et al, 2010). SH is mainly used for treating purulent skin infections, respiratory tract infections, including pneumonia in elderly patients, and chronic bronchitis (Wang et al, 2002).…”