The distinctive jaw and alveolar bone regeneration

Akintoye, Sunday O.

doi:10.1111/odi.12761

Cited by 16 publications

(11 citation statements)

References 19 publications

(28 reference statements)

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“…The current clinical techniques mainly used for the treatment of alveolar bone defects [4] are bone grafting and guided bone regeneration (GBR). Autologous bone grafting is considered to be the gold standard for bone repair [5,6,7,8], but it has many limitations such as long operation and recovery times, possible insufficient bone mass in patients, and numerous complications [9,10]. GBR uses a barrier to provide space that is filled with new bone to compensate for deficiencies [11,12].…”

Section: Introductionmentioning

confidence: 99%

Transforming Growth Factor-β3/Chitosan Sponge (TGF-β3/CS) Facilitates Osteogenic Differentiation of Human Periodontal Ligament Stem Cells

Qiao

et al. 2019

IJMS

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Periodontal disease is the main reason for tooth loss in adults. Tissue engineering and regenerative medicine are advanced technologies used to manage soft and hard tissue defects caused by periodontal disease. We developed a transforming growth factor-β3/chitosan sponge (TGF-β3/CS) to repair periodontal soft and hard tissue defects. We investigated the proliferation and osteogenic differentiation behaviors of primary human periodontal ligament stem cells (hPDLSCs) to determine the bioactivity and potential application of TGF-β3 in periodontal disease. We employed calcein-AM/propidium iodide (PI) double labeling or cell membranes (CM)-Dil labeling coupled with fluorescence microscopy to trace the survival and function of cells after implantation in vitro and in vivo. The mineralization of osteogenically differentiated hPDLSCs was confirmed by measuring alkaline phosphatase (ALP) activity and calcium content. The levels of COL I, ALP, TGF-βRI, TGF-βRII, and Pp38/t-p38 were assessed by western blotting to explore the mechanism of bone repair prompted by TGF-β3. When hPDLSCs were implanted with various concentrations of TGF-β3/CS (62.5–500 ng/mL), ALP activity was the highest in the TGF-β3 (250 ng/mL) group after 7 d (p < 0.05 vs. control). The calcium content in each group was increased significantly after 21 and 28 d (p < 0.001 vs. control). The optimal result was achieved by the TGF-β3 (500 ng/mL) group. These results showed that TGF-β3/CS promotes osteogenic differentiation of hPDLSCs, which may involve the p38 mitogen-activated protein kinase (MAPK) signaling pathway. TGF-β3/CS has the potential for application in the repair of incomplete alveolar bone defects.

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Section: Introductionmentioning

confidence: 99%

Transforming Growth Factor-β3/Chitosan Sponge (TGF-β3/CS) Facilitates Osteogenic Differentiation of Human Periodontal Ligament Stem Cells

Qiao

et al. 2019

IJMS

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“…In turn, the development of the periosteum matches that of its underlying bone, being either endochondral or intramembranous [24,25]. Seven of the nine HNJCS were found at the distal and proximal aspects of the mandible or maxilla, all which undergo an endochondral-like ossification [32]. One case was identified at the mandibular body, which contrastingly undergoes intramembranous ossification [30].…”

Section: Reviewmentioning

confidence: 95%

Head and Neck Juxtacortical Chondrosarcoma: A Systematic Review

Jones¹,

Alwani²,

Summerlin³

et al. 2019

AOHNS

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Objective: To present a case and systematically evaluate trends in clinical presentation, imaging, histopathology, and management modalities and outcomes of all head and neck juxtacortical chondrosarcoma (HNJCS) cases reported in the existing literature. Methods: We describe a rare case of HNJCS from our tertiary referral center following which the PubMed, MEDLINE, Embase, and Web of Science databases were searched for all HNJCS reports. Relevant titles and abstracts were screened. Resulting full-text articles were assessed for eligibility, and remaining studies were included for data extraction, summarization, and analysis. Results: Potential studies were identified dating from May 1946 to February 2019. A total of nine cases were included in our systematic review, eight of which were identified from full-text articles and one recruited from our tertiary referral center. The median presentation age was 41 years with a 66.7% male preponderance. The commonest presenting sign was a painless, isolated swelling after a median symptom duration of 2.5 months. CT imaging revealed hypodense lesions with peripheral enhancement and micro-calcifications. T1-weighted MRI showed hypo-to iso-intense, lobulated masses with peripheral and/or septal enhancement. The masses were diffusely hyper-intense on T2-weighted MRI. Histopathology demonstrated septated lobules of malignant hyaline cartilage with a peripheral fibrous capsule. Most tumors were low-or intermediate-grade tumors with average diameter of 4.3 cm. Local recurrence was identified in only one case (four years after initial resection). No distal and/or nodal metastases were identified. All tumors were managed by wide-or narrow-margin surgical excision. Two reports employed adjuvant treatment. There was no evidence of disease at final follow-up (median of 1.5 years). Conclusion: To the best of our knowledge, only nine cases of HNJCS have been adequately described. HNJCS have relatively consistent clinical and diagnostic profile regardless of location in the body. Surgical management yields excellent outcomes with low recurrence rates.

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“…The tooth is a hard tissue containing a vascularized and nerve-rich pulp chamber and is surrounded by the tooth-supporting periodontium, including the periodontal ligament, cementum, and alveolar bone. Multiple stem cell niches exist in dental tissues, as teeth are uniquely shaped and are subject to complicated microenvironments with occlusal force and microorganisms [ 53 ]. To date, more than seven kinds of dental stem cells have been found, including dental pulp stem cells (DPSCs) [ 54 ], human exfoliated deciduous teeth (SHED) [ 55 ], periodontal ligament stem cells (PDLSCs) [ 56 ], dental follicle progenitor cells (DFPCs) [ 57 ], stem cells from dental apical papilla (SCAP) [ 58 ], tooth germ stem cells (TGSCs) [ 59 ], gingival mesenchymal stem cells (GMSCs) [ 60 ], and human natal dental pulp stem cells (NDP-SCs) ( Figure 4 ) [ 61 ].…”

Section: Periodontiummentioning

confidence: 99%

Spatial Distributions, Characteristics, and Applications of Craniofacial Stem Cells

Zhang

Yuan

et al. 2020

Stem Cells International

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Stem cells play an irreplaceable role in the development, homeostasis, and regeneration of the craniofacial bone. Multiple populations of tissue-resident craniofacial skeletal stem cells have been identified in different stem cell niches, including the cranial periosteum, jawbone marrow, temporomandibular joint, cranial sutures, and periodontium. These cells exhibit self-renewal and multidirectional differentiation abilities. Here, we summarized the properties of craniofacial skeletal stem cells, based on their spatial distribution. Specifically, we focused on the in vivo genetic fate mapping of stem cells, by exploring specific stem cell markers and observing their lineage commitment in both the homeostatic and regenerative states. Finally, we discussed their application in regenerative medicine.

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The distinctive jaw and alveolar bone regeneration

Cited by 16 publications

References 19 publications

Transforming Growth Factor-β3/Chitosan Sponge (TGF-β3/CS) Facilitates Osteogenic Differentiation of Human Periodontal Ligament Stem Cells

Transforming Growth Factor-β3/Chitosan Sponge (TGF-β3/CS) Facilitates Osteogenic Differentiation of Human Periodontal Ligament Stem Cells

Head and Neck Juxtacortical Chondrosarcoma: A Systematic Review

Spatial Distributions, Characteristics, and Applications of Craniofacial Stem Cells

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