Head and Neck Juxtacortical Chondrosarcoma: A Systematic Review

Jones, Alexander Joseph; Alwani, Mohamedkazim; Summerlin, Don‐John; Sim, Michael W.

doi:10.24983/scitemed.aohns.2019.00107

Cited by 2 publications

(1 citation statement)

References 33 publications

(90 reference statements)

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“…The most frequently involved anatomical structure was identified as the cricoid cartilage, and dyspnea, hoarseness and the sensation of mass in the throat were the most frequently reported symptoms. The surgical technique and the degree of histological differentiation were factors correlated with the prognosis [22]. In another systematic review that included only nine cases reported from 1946 to 2019, Jones and collaborators found a relatively low rate of loco-regional recurrences with only one of these cases recurring 4 years after surgical treatment.…”

Section: Discussionmentioning

confidence: 99%

Head and Neck Low Grade Chondrosarcoma—A Rare Entity

Mireștean,

Simionescu,

Iancu

et al. 2023

Diagnostics

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Chondrosarcoma represents approximately 0.1% of all neoplasms of the head and neck and is considered a rare disease with a relatively good prognosis. The 5-year overall survival (OS) rate is estimated at 70–80%, being considered a disease with a low growth rate. Approximately 13% of all cases of chondrosarcoma are located in the region of the head and neck. We present the case of a 30-year-old patient without a medical history who reported dysphagia, swallowing difficulty, neck mass sensation and dysphonia that started insidiously after an upper respiratory tract infection. Subsequently, the patient was diagnosed with a low-grade glosso-epiglottic region chondrosarcoma and was multimodally treated with surgery followed by chemotherapy and radiotherapy. The radiation treatment was delivered with a Rokus M40 former Soviet Union cobalt machine without any image guidance capabilities. The inability to obtain resection margin information justified an aggressive adjuvant treatment with chemotherapy and radiotherapy. The early loss from the oncological record without recurrence of the disease could be associated in this case with the consequence of a major complication, of which we could assume an aspiration pneumonia secondary to a dysphagia associated with an aggressive multidisciplinary treatment. Large tumor size and positive resection margins (R1 resection) are risk factors that support an intensive adjuvant approach in order to reduce the risk of recurrence, but the low grade of tumor associated with a lower risk of recurrence as well as the adverse events (AE) of adjuvant radiotherapy and chemotherapy justify a more reserved therapeutic approach. Taking into account the longer life expectancy of these patients, it is recommended to use a more conformal irradiation technique in order to reduce doses to radiosensitive structures as well as to omit elective neck irradiation, taking into account the lower risk of lymph node involvement. The lack of guidelines, which include very rare tumors including low grade chondrosarcoma of the head and neck, makes a unified approach difficult, but the data presented in case reports could contribute to choosing the regimen that offers the best therapeutic ratio.

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Section: Discussionmentioning

confidence: 99%

Head and Neck Low Grade Chondrosarcoma—A Rare Entity

Mireștean,

Simionescu,

Iancu

et al. 2023

Diagnostics

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Head and Neck Low Grade Chondrosarcoma– A Rare Entity

Mireștean¹,

Eugenia²,

Iancu³

et al. 2023

Preprint

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Chondrosarcoma, represents approximately 0.1% of all neoplasms of the head and neck, being considered a rare disease, but with a relatively good prognosis. The 5-year overall survival (OS) rate is estimated at 70-80%, being considered a disease with a low growth rate. About 13% of all cases of chondrosarcoma, are located in the region of the head and neck. We present the case of a young patient treated multimodally, lost from the oncological records less than two years after the diagnosis, without evidence of disease progression. The early loss from the oncological follow-up programs of patients with a lower risk of early repalpse, without evidence of a recurrence or metastasis could be the consequence of a major complication among which we could assume an aspiration pneumonia secondary to a dysphagia, associated with an aggressive multidisciplinary treatment. Large tumor size and positive resection margins (R1 resection) are risk factors that support an intensive adjuvant approach in order to reduce the risk of recurrence, but the low grade of tumor, associating a lower risk of recurrence as well as the adverse events (AE) of adjuvant radiotherapy and chemotherapy justifies a more reserved therapeutic approach. Taking into account the longer life expectancy of these patients, it is recommended to use a more conformal irradiation technique in order to reduce doses to radiosensitive structures as well as to omit elective neck irradiation, taking into account the lower risk of lymph node involvement. The lack of guidelines that include very rare tumors including low grade chondrosarcoma of head and neck make a unified approach difficult, but the data presented even in case reports could contribute to choosing the regimen that offers the best therapeutic ratio.

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Head and Neck Juxtacortical Chondrosarcoma: A Systematic Review

Cited by 2 publications

References 33 publications

Head and Neck Low Grade Chondrosarcoma—A Rare Entity

Head and Neck Low Grade Chondrosarcoma—A Rare Entity

Head and Neck Low Grade Chondrosarcoma– A Rare Entity

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