The Diseased Lung and Drugs

Camus, P.; Jeannin, L

doi:10.1007/978-3-642-69132-4_7

Cited by 3 publications

(1 citation statement)

References 52 publications

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“…Although PGE 2 is poorly metabolized in cell culture, it has a half-life of less than 30 s in the circulation (Camus and Jeannin, 1984); thus, PGE 2 is an autocrine or paracrine hormone acting locally to stimulate airway secretion when released into the surface airway liquid. In vivo, products secreted by activated AMs cross the epithelium to induce both local and systemic actions.…”

Section: Macrophage-secreted Pge 2 Enhances Airway Epithelial Currentmentioning

confidence: 99%

Prostanoids Secreted by Alveolar Macrophages Enhance Ionic Currents in Swine Tracheal Submucosal Gland Cells

Liu

Mamoon²,

Farley³

2005

J Pharmacol Exp Ther

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Section: Macrophage-secreted Pge 2 Enhances Airway Epithelial Currentmentioning

confidence: 99%

Prostanoids Secreted by Alveolar Macrophages Enhance Ionic Currents in Swine Tracheal Submucosal Gland Cells

Liu

Mamoon²,

Farley³

2005

J Pharmacol Exp Ther

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Role of the Lung in Accumulation and Metabolism of Xenobiotic Compounds — Implications for Chemically Induced Toxicity

Foth

1995

Critical Reviews in Toxicology

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The mammalian lung is exposed to and affected by many airborne and bloodborne foreign compounds. This review summarizes the role of lung in accumulation and metabolism of xenobiotics, some of which are spontaneously reactive or are metabolically activated to toxic intermediates. The specific architectural arrangement of mammalian lung favors that so-called pneumophilic drugs are filtered out of the blood and are retained within the tissue as shown in particular for amphetamine, chlorphentermine, amiodarone, imipramine, chlorpromazine, propranolol, local anaesthetics, and some miscellaneous therapeutics. There is strong evidence that intrapulmonary distribution activity and regulation of drug-metabolizing enzymes in lung is distinct from liver. This review focuses on the metabolic rate of selected compounds in lung such as 5-fluoro-2'-deoxyuridine, local anesthetics, nicotine, benzo(alpha)pyrene, ipomeanol, 4-methylnitrosamino-1-(3-pyridyl)-1-butanone. It is widely accepted that the formation of radical species is a key event in the pneumotoxic mechanisms induced by bleomycin, paraquat, 3-methylindole, butylhydroxytoluene, or nitrofurantoin. Finally, methodological approaches to assess the capacity of lung to eliminate foreign compounds as well as biochemical features of the pulmonary tissue are evaluated briefly.

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Chemical-induced autoimmune reactions and spanish toxic oil syndrome. Focus on hydantoins and related compounds

Kammüller

Bloksma

Seinen

1988

Journal of Toxicology: Clinical Toxicology

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Autoimmune diseases comprise a wide spectrum of overlapping, systemic and organ-specific disorders. Although, etiology and pathogenesis of such disorders are largely unknown, endogenous host factors and exogenous agents, such as viruses, bacteria, and small molecular weight chemicals, drugs and food components, are believed to be involved. The toxicological significance of low molecular weight compounds on induction of autoimmune disorders is illustrated by the toxic oil syndrome (TOS), a chemically induced epidemic, observed in Spain since 1981. The causative chemical(s) of TOS is still elusive, but an association between ingestion of refined aniline-adulterated rapeseed oil and the syndrome is well-documented. Epidemiological, clinical and immunopathological symptoms of TOS are briefly reviewed. The striking resemblance with immunological disorders, observed in man upon medication with hydantoins and related compounds, is demonstrated. The likeliness of formation of a hydantoin-related compound in the aniline-adulterated oil is evidenced and its role as possible toxic agent in TOS is proposed. Further, the presence of hydantoins and related compounds in food is briefly reviewed and it is suggested that these chemicals may account for a portion of idiopathic autoimmune diseases observed in man. The need for development of animal models to assess this kind of immunotoxicological effects is stressed.

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The Diseased Lung and Drugs

Cited by 3 publications

References 52 publications

Prostanoids Secreted by Alveolar Macrophages Enhance Ionic Currents in Swine Tracheal Submucosal Gland Cells

Prostanoids Secreted by Alveolar Macrophages Enhance Ionic Currents in Swine Tracheal Submucosal Gland Cells

Role of the Lung in Accumulation and Metabolism of Xenobiotic Compounds — Implications for Chemically Induced Toxicity

Chemical-induced autoimmune reactions and spanish toxic oil syndrome. Focus on hydantoins and related compounds

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