The discrimination of stenosed carotid bifurcation models with smooth and irregular plaque surface. Part I. Laser and ultrasonic Doppler flow studies

Lesniak, B.; Kałużyński, K.; Liepsch, D.; Pałko, T.

doi:10.1016/s1350-4533(02)00024-3

Cited by 7 publications

(3 citation statements)

References 29 publications

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“…While Lesniak et al [32] have previously investigated Doppler techniques (using a laser Doppler anemometer and a pulsed Doppler flowmeter) to observe alterations in blood-velocity patterns due to surface irregularities in the carotid artery vessel, our approach differed in that surface irregularity in the current study was modelled as physiologically realistic ulcerations, as opposed to simple protrusions on the vessel wall surface. In addition, our precise control of ulcer shape and size allowed us to investigate the effect of ulcer geometry rather than simply introducing a higher frequency of protrusion.…”

Section: Discussionmentioning

confidence: 99%

Clinical Doppler ultrasound for the assessment of plaque ulceration in the stenosed carotid bifurcation by detection of distal turbulence intensity: a matched model study

et al. 2009

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The assessment of flow disturbances due to carotid plaque ulceration may provide added diagnostic information to Doppler ultrasound (DUS) of the carotid stenosis, and indicate whether the associated hemodynamics are a potential thromboembolic source. We evaluated the effect of ulceration in a moderately stenosed carotid bifurcation on distal turbulence intensity (TI) measured using clinical DUS in matched anthropomorphic models. Several physiologically relevant ulcer geometries (hemispherical, mushroom-shaped, and ellipsoidal pointing distally and proximally) and sizes (2-mm, 3-mm and 4-mm diameter hemispheres) were investigated. An offline analysis was performed to determine several velocity-based parameters from ensemble-averaged spectral data, including TI. Significant elevations in TI were observed in the post-stenotic flow field of the stenosed carotid bifurcation by the inclusion of ulceration (P < 0.001) in a region two common carotid artery diameters distal to the site of ulceration during the systolic peak and the diastolic phase of the cardiac cycle. Both the size and shape of ulceration had a significant effect on TI in the distal region (P < 0.001). Due to the use of a clinical system, this method provides the means to evaluate for plaque ulcerations in patients with carotid atherosclerosis using DUS.

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Section: Discussionmentioning

confidence: 99%

Clinical Doppler ultrasound for the assessment of plaque ulceration in the stenosed carotid bifurcation by detection of distal turbulence intensity: a matched model study

et al. 2009

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“…However, PIV and LDV continue to play a key role in applications where CFD remains relatively immature, such as for models with moving boundaries, 30,82 fine embedded devices, 10,39 and especially where flow instabilities and/or turbulence may occur. 4,38 In the past decade, much of the work on imaging of large artery hemodynamics has taken place in the context of medical imaging, with the obvious aim of deriving hemodynamic information from in vivo studies. Some of the earliest work focused on X-ray angiography, which, as a by-product of its relatively high temporal resolution, can be used to visualize flow dynamics during the intra-arterial injection and washout of the contrast agent.…”

Section: Flow Imagingmentioning

confidence: 99%

Flow Imaging and Computing: Large Artery Hemodynamics

2005

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The objective of our session at the International Bio-Fluid Mechanics Symposium and Workshop was at the International Bio-Fluid Mechanics Symposium and Workshop to review the state-of-the-art in, and identify future directions for, imaging and computational modeling of blood flow in the large arteries and the microcirculation. Naturally, talks in other sessions of the workshop overlapped this broad topic, and so here we summarize progress within the last decade in terms of the technical development and application of flow imaging and computing, rather than the knowledge derived from specific studies. We then briefly discuss ways in these tools may be extended, and their application broadened, in the next decade. Furthermore, owing to the conceptual division between the hemodynamics of large arteries, and those within the microcirculation, we review these regimes separately: The former here by Steinman and Taylor; and the latter in a separate paper by Cristini.

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“…Surveys with respect to in vitro and in vivo measuring methods were presented in the current literature, regarding experimental investigations focused on the determination of pressure and velocity fields in blood vessels (9). Furthermore, ultrasonic Doppler velocimetry (UDV) or optic techniques like laser Doppler anemometry and particle image velocimetry (PIV) were usually utilized to quantify fluid velocity (10)(11)(12)(13)(14). Therefore, our concept was to develop a novel artificial flow channel, which offers the possibility of transapical access to the left ventricle and toward the thoracic aorta combined with fluid dynamical testing methods.…”

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confidence: 99%

Development and In Vitro Characterization of a New Artificial Flow Channel

Wendt¹,

Stühle²,

Hou³

et al. 2011

Artificial Organs

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To date, cardiac valve diseases are considered as a major public health problem and most frequently, the aortic valve is affected. To treat high-risk patients, catheter-based techniques have been developed recently, avoiding open heart surgery and/or cardiopulmonary bypass. Although these sophisticated and rapidly emerging catheter-based technologies do allow a minimally invasive treatment option of high-risk patients on the one hand, further developments and in vitro testing under physiological conditions are necessary, on the other hand, in order to further optimize them for clinical routines. Therefore, we present the concept of a new multifunctional flow channel, offering (i) the possibility of transapical access; (ii) the simulation of physiological flow conditions; and (iii) the evaluation of the fluid flow by 2D particle image velocimetry within a wide range of parameters.

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The discrimination of stenosed carotid bifurcation models with smooth and irregular plaque surface. Part I. Laser and ultrasonic Doppler flow studies

Cited by 7 publications

References 29 publications

Clinical Doppler ultrasound for the assessment of plaque ulceration in the stenosed carotid bifurcation by detection of distal turbulence intensity: a matched model study

Clinical Doppler ultrasound for the assessment of plaque ulceration in the stenosed carotid bifurcation by detection of distal turbulence intensity: a matched model study

Flow Imaging and Computing: Large Artery Hemodynamics

Development and In Vitro Characterization of a New Artificial Flow Channel

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