The discovery of type IV interferon system revolutionizes interferon family and opens up a new frontier in jawed vertebrate immune defense

Su, Jian

doi:10.1007/s11427-022-2112-0

Cited by 26 publications

(9 citation statements)

References 6 publications

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“…The recently discovered type IV IFN, IFN-υ, has conserved features in terms of sequence, gene locus, receptor system, signaling pathway and even antiviral function, and has been shown to be potentially present in fish, amphibians, reptiles, birds, and primitive mammals ( Chen et al, 2022a , 2023 a; Su, 2022 ; Chen et al, 2023 ). IFN-υ and its 2 receptor subunits, IFN-υR1 and IL10RB have been verified experimentally in zebrafish and amphibian model X. laevis ( Chen et al, 2022a , 2023 a).…”

Section: Discussionmentioning

confidence: 99%

“…It is well known that different types of IFNs are classified on the basis of structural feature, gene locus position, receptor utilization, and signaling pathway ( Negishi et al, 2018 ; Lazear et al, 2019 ; Chen et al, 2022a ). Since the initial discovery of IFN in 1957, 4 types of IFNs, including type I IFN such as IFNα/β, type II IFN also named as IFN-γ, type III IFN as IFN-λ, and type IV IFN as IFN-υ have been identified in vertebrates ( Isaacs and Lindenmann, 1957 ; Naylor et al, 1983 ; Kotenko et al, 2003 ; Chen et al, 2022a ; Su, 2022 ; Sheppard et al, 2003 ).…”

Section: Introductionmentioning

confidence: 99%

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IFN-υ and its receptor subunits, IFN-υR1 and IL10RB in mallard Anas platyrhynchos

Pang,

Chen,

Liu

et al. 2024

Poultry Science

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

IFN-υ and its receptor subunits, IFN-υR1 and IL10RB in mallard Anas platyrhynchos

Pang,

Chen,

Liu

et al. 2024

Poultry Science

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“…Notably, type IV IFN shares a C-terminal sequence with type I IFN and utilizes the same signal-transduction receptor, IL10R2, as type III IFN. This suggests a common ancestral origin for type IV IFN and type I/III IFNs ( 45 , 94 ).…”

Section: Ifns Receptors and Signal Transduction Pathwaysmentioning

confidence: 94%

Role of interferons in the antiviral battle: from virus-host crosstalk to prophylactic and therapeutic potential in SARS-CoV-2 infection

Mihaescu,

Chifiriuc,

Filip

et al. 2024

Front. Immunol.

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Mammalians sense antigenic messages from infectious agents that penetrate the respiratory and digestive epithelium, as well as signals from damaged host cells through membrane and cytosolic receptors. The transduction of these signals triggers a personalized response, depending on the nature of the stimulus and the host’s genetics, physiological condition, and comorbidities. Interferons (IFNs) are the primary effectors of the innate immune response, and their synthesis is activated in most cells within a few hours after pathogen invasion. IFNs are primarily synthesized in infected cells, but their anti-infective effect is extended to the neighboring cells by autocrine and paracrine action. The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) pandemic in 2019 was a stark reminder of the potential threat posed by newly emerging viruses. This pandemic has also triggered an overwhelming influx of research studies aiming to unveil the mechanisms of protective versus pathogenic host immune responses induced by SARS‐CoV‐2. The purpose of this review is to describe the role of IFNs as vital players in the battle against SARS‐CoV-2 infection. We will briefly characterize and classify IFNs, present the inductors of IFN synthesis, their sensors, and signaling pathways, and then discuss the role of IFNs in controlling the evolution of SARS-CoV-2 infection and its clinical outcome. Finally, we will present the perspectives and controversies regarding the prophylactic and therapeutic potential of IFNs in SARS-CoV-2 infection.

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“…Structurally, they belong to Class II helical cytokines [231,232]. IFNs have been classified in four types that were all present in primitive vertebrates, but while Type I and II IFNs are present in all groups of vertebrates, Type III is absent in teleosts and Type IV is absent in Metatheria and Eutheria mammals [230,233,234]. Types I, III, and IV IFNs are key players of innate immunity that are mainly produced by virally infected cells and, through induction of an inflammatory response, play an instrumental role in clearing viral infections.…”

Section: Interferonsmentioning

confidence: 99%

Molecular Actors of Inflammation and Their Signaling Pathways: Mechanistic Insights from Zebrafish

Leiba

Özbilgiç

Hernández

et al. 2023

Biology

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Inflammation is a hallmark of the physiological response to aggressions. It is orchestrated by a plethora of molecules that detect the danger, signal intracellularly, and activate immune mechanisms to fight the threat. Understanding these processes at a level that allows to modulate their fate in a pathological context strongly relies on in vivo studies, as these can capture the complexity of the whole process and integrate the intricate interplay between the cellular and molecular actors of inflammation. Over the years, zebrafish has proven to be a well-recognized model to study immune responses linked to human physiopathology. We here provide a systematic review of the molecular effectors of inflammation known in this vertebrate and recapitulate their modes of action, as inferred from sterile or infection-based inflammatory models. We present a comprehensive analysis of their sequence, expression, and tissue distribution and summarize the tools that have been developed to study their function. We further highlight how these tools helped gain insights into the mechanisms of immune cell activation, induction, or resolution of inflammation, by uncovering downstream receptors and signaling pathways. These progresses pave the way for more refined models of inflammation, mimicking human diseases and enabling drug development using zebrafish models.

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The discovery of type IV interferon system revolutionizes interferon family and opens up a new frontier in jawed vertebrate immune defense

Cited by 26 publications

References 6 publications

IFN-υ and its receptor subunits, IFN-υR1 and IL10RB in mallard Anas platyrhynchos

IFN-υ and its receptor subunits, IFN-υR1 and IL10RB in mallard Anas platyrhynchos

Role of interferons in the antiviral battle: from virus-host crosstalk to prophylactic and therapeutic potential in SARS-CoV-2 infection

Molecular Actors of Inflammation and Their Signaling Pathways: Mechanistic Insights from Zebrafish

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