The discovery of new scaffold of plant activators: From salicylic acid to benzotriazole

Chang, Kang-Wei; Chen, Jianqin; Shi, Yanhong; Sun, Meijian; Li, Pengfei; Zhao, Zhenjiang; Zhu, Weiping; Li, Honglin; Xu, Yufang; Li, Baoju; Qian, Xuhong

doi:10.1016/j.cclet.2017.02.004

Cited by 10 publications

(2 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chang et al . (2017) 80 virtually screened the Maybridge database, a collection of over 53 000 organic compounds, using the chemical structures of ASM, MeSA and SA to identify three benzotriazole lead compounds. From one of these (L1), which had a 3D structure similar to ASM, two derivatives (3a and 4a) were potent SAR activators.…”

Section: The Resurrection Of Chemical Ir Agentsmentioning

confidence: 99%

The rise, fall and resurrection of chemical‐induced resistance agents

Yassin

Ton

Rolfe

et al. 2021

Pest Management Science

View full text Add to dashboard Cite

Since the discovery that the plant immune system could be augmented for improved deployment against biotic stressors through the exogenous application of chemicals that lead to induced resistance (IR), many such IR‐eliciting agents have been identified. Initially it was hoped that these chemical IR agents would be a benign alternative to traditional chemical biocides. However, owing to low efficacy and/or a realization that their benefits sometimes come at the cost of growth and yield penalties, chemical IR agents fell out of favour and were seldom used as crop protection products. Despite the lack of interest in agricultural use, researchers have continued to explore the efficacy and mechanisms of chemical IR. Moreover, as we move away from the approach of ‘zero tolerance’ toward plant pests and pathogens toward integrated pest management, chemical IR agents could have a place in the plant protection product list. In this review, we chart the rise and fall of chemical IR agents, and then explore a variety of strategies used to improve their efficacy and remediate their negative adverse effects. © 2021 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

show abstract

Section: The Resurrection Of Chemical Ir Agentsmentioning

confidence: 99%

The rise, fall and resurrection of chemical‐induced resistance agents

Yassin

Ton

Rolfe

et al. 2021

Pest Management Science

View full text Add to dashboard Cite

show abstract

“…This computer-aided design (CAD) drug design strategy has been increasingly recognized and utilized in pesticide discovery and property analysis ( Xia et al, 2014 ; Veselinovi et al, 2015 ; Burden et al, 2016 ). Using SA, MeSA, BTH, and Tiadinil, the four known immune inducers as query templates, Chang et al (2017) performed virtual screening against the 5,3000 hit-like and lead-like compounds in the Maybridge database and identified three benzotriazole scaffolds as promising leading compounds. One of them, L1 shows high 3D structure similarity to BTH despite their differences in 2D topology.…”

Section: Emerging Trendsmentioning

confidence: 99%

Recent Advances in Synthetic Chemical Inducers of Plant Immunity

Zhou

Wang

2018

Front. Plant Sci.

View full text Add to dashboard Cite

Different from the conventional biocidal agrochemicals, synthetic chemical inducers of plant immunity activate, bolster, or prime plant defense machineries rather than directly acting on the pathogens. Advances in combinatorial synthesis and high-throughput screening methods have led to the discovery of various synthetic plant immune activators as well as priming agents. The availability of their structures and recent progress in the mechanistic understanding of plant immune responses have opened up the possibility of identifying new or more potent chemical inducers through rational design. In this review, we first summarize the chemical inducers identified through large-scale screening and then discuss the emerging trends in the identification and development of novel plant immune inducers including natural elicitor based chemical derivation, bifunctional combination, and computer-aided design.

show abstract

Synthesis of Structurally Diverse Benzotriazoles via Rapid Diazotization and Intramolecular Cyclization of 1,2‐Aryldiamines

et al. 2019

View full text Add to dashboard Cite

An operationally simple method has been developed for the preparation of N‐unsubstituted benzotriazoles by diazotization and intramolecular cyclization of a wide range of 1,2‐aryldiamines under mild conditions, using a polymer‐supported nitrite reagent and p‐tosic acid. The functional group tolerance of this approach was further demonstrated with effective activation and cyclization of N‐alkyl, ‐aryl, and ‐acyl ortho‐aminoanilines leading to the synthesis of N1‐substituted benzotriazoles. The synthetic utility of this one‐pot heterocyclization process was exemplified with the preparation of a number of biologically and medicinally important benzotriazole scaffolds, including an α‐amino acid analogue.

show abstract

The discovery of new scaffold of plant activators: From salicylic acid to benzotriazole

Cited by 10 publications

References 42 publications

The rise, fall and resurrection of chemical‐induced resistance agents

The rise, fall and resurrection of chemical‐induced resistance agents

Recent Advances in Synthetic Chemical Inducers of Plant Immunity

Synthesis of Structurally Diverse Benzotriazoles via Rapid Diazotization and Intramolecular Cyclization of 1,2‐Aryldiamines

Contact Info

Product

Resources

About