The Disappearance of Transfusion-Transmitted Hepatitis C Virus Infections in the United States

Gresens, Christopher J.; Holland, Paul V.

doi:10.1016/s1089-3261(05)70212-9

Cited by 10 publications

(3 citation statements)

References 33 publications

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“…Similarly, the improvement in donor selection and the introduction of screening tests have reduced the risks of HCV infection associated with transfusion. 2,19,21,51 Therefore, the current risk rates for HCV infection in patients on HD may differ substantially from those reported 10 or 15 years ago. 20 In this study, previous blood transfusion was an independent risk factor for HCV infection, according to the literature.…”

Section: Discussionmentioning

confidence: 98%

Hepatitis C in hemodialysis: the contribution of injection drug use

et al. 2010

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Background: Hepatitis C virus (HCV) infection is the most common cause of acute or chronic hepatitis in patients on hemodialysis (HD). The purpose of this study was to describe the prevalence of positive HCV RNA and investigate injection drug use as an emerging risk factor in patients with chronic renal disease on HD. Methods: This was a multicenter cross-sectional study with 325 patients with chronic renal disease on HD in the period between August 1, 2005 to August 30, 2006, receiving care at four institutions in the city of Porto Alegre, Southern Brazil. Epidemiological data were collected by means of a structured questionnaire. The following laboratory tests were performed: alanine aminotransferase (ALT), anti-hepatitis C virus antibodies (anti-HCV), and qualitative polymerase chain reaction (PCR). Results: Of 325 patients, 68 had positive HCV RNA results. The comparison between patients with positive and negative PCR results revealed signifi cant differences in duration of HD (mean = 71 versus 52.4 months; p = 0.02); previous blood transfusion (92% versus 72%; p < 0.01); injection drug use (13% versus 0.7%; p < 0.01); anti-HCV positivity at start of HD therapy (60% versus 4%; p < 0.01); and mean ALT value (39 versus 26.5; p < 0.01). Logistic regression analysis showed a positive HCV RNA independently associated to being on HD for more than fi ve years [OR: 2.1 (95% CI 1.2 -3.8)]; previous blood transfusion [OR: 3.7 (95% CI 1.4 -9.5)]; and injection drug use [OR: 22.6 (95% CI 4.2 -119.6)]. Conclusion: Injection drug use was an independent risk factor for HCV infection among chronic renal disease patients on HD.

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Section: Discussionmentioning

confidence: 98%

Hepatitis C in hemodialysis: the contribution of injection drug use

et al. 2010

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“…Before 1990, HCV accounted for almost all transfusion-transmitted cases of non-A, non-B hepatitis, with a risk of about 1 per 200 transfusions in the United States (36). Following the introduction of improved HCV antibody assays in 1992 and 1996, the risk fell to 1 per 103,000 units transfused (34), and recently, following the introduction of nucleic acid testing, the risk is 1 per 1,935,000 units transfused (38).…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Hepatitis C Infection in a Population of Asymptomatic People in a Checkup Unit in Mexico City

et al. 2005

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Hepatitis C virus (HCV) infection has an estimated prevalence of 3% around the world. Unfortunately, many persons with HCV infection are asymptomatic. The aim of this study was to determine the prevalence of hepatitis C Virus infection in asymptomatic persons. This study was carried out in a population-based cross-sectional study in the Checkup Unit of University Hospital in Mexico City. Patients with two or more HCV risk factors were studied. Serum specimens from all patients were screened for HCV RNA by qualitative polymerase chain reaction (PCR). HCV RNA-positive serum was also screened by quantitative PCR and for HCV genotype. Three hundred asymptomatic people were included, 194 men and 106 women, with a mean age of 46.8+/-11.9. Six (2%) of the 300 people were positive and viremic. The most common risk factors in positive patients were manicures or pedicures with a nonpersonal instrument and more than three sexual partners. We concluded that hepatitis C is frequent in asymptomatic people, and those people are often viremic. In addition, this study suggests that the spectrum of liver disease in asymptomatic and newly diagnosed HCV-positive persons is broad.

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“…En esta investigación se reporta una seroprevalendescrito en Colombia 7,9 y en otros países suramerica- En cambio, esta frecuencia es similar a las cifras reportadas en países como Cuba, 31 32 y Estados Unidos. 33 Esta diversidad epidemiológica en las prevalencias de Anti-HCV puede estar relacionada con las diferen-sición a factores de riesgo transfusional, o con el nivel cultural y socioeconómico de la población de donantes de estos países. 7 En el mundo, la prevalencia de Anti-HTLV varía de acuerdo con la región y la población estudiada.…”

Section: 11-15unclassified

Seroprevalencia de patógenos infecciosos en donantes de sangre, Bolívar-Colombia, 2006-2010

Arellano

et al. 2012

Hech Microb.

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INTRDUCCIÓN Para reducir el riesgo de transmisión transfusional se hace necesario fortalecer el componente de diagnóstico precoz de los patógenos asociados a este tipo de transmisión y para lograrlo se necesita conocer la frecuencia de estos agentes infecciosos y su asociación con las características clínicas iniciales en la población de donantes. OBJETIVO Determinar la seroprevalencia de los principales marcadores infecciosos en los donantes atendidos en un banco de sangre con alta cobertura en el departamento de Bolívar, y su asociación con la información obtenida en la encuesta previa al tamizaje serológico. MATERIALES Y MÉTODOS Estudio tranversal, analítico de corte retrospectivo (agosto de 2006 a diciembre de 2010). RESULTADOS Se estudiaron 20264 donantes de sangre consecutivos, encontrándose una seroprevalencia global de 6,2%de casos, con predominio de Anti-HBc (2,62%), seguido de Anti-HCV (1,07%), Anti-T. cruzi (0,83%) y Anti- T. pallidum (0,75%), Anti-HTLV (0,68%), Anti-HIV (0,39%) y HBsAg (0,33%). El 0,33% de los donantes presentó infecciones múltiples. No se encontró diferencia significativa entre la seroprevalencia de los marcadores infecciosos analizados y la medida de edad, la ocupación o el tipo de exposición a comportamientos o procedimientos de riesgo presentes en la población de donantes serorreactivos. CONCLUSIONES Los marcadores infecciosos analizados no presentaron cambios siginificativos en su seroprevalencia excepto Anti-HTLV y es este comportamiento epidemiológico el que permitiría pensar en la aplicación de la estrategia de tamización universal en el departamento de Bolívar.

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The Disappearance of Transfusion-Transmitted Hepatitis C Virus Infections in the United States

Cited by 10 publications

References 33 publications

Hepatitis C in hemodialysis: the contribution of injection drug use

Hepatitis C in hemodialysis: the contribution of injection drug use

Prevalence of Hepatitis C Infection in a Population of Asymptomatic People in a Checkup Unit in Mexico City

Seroprevalencia de patógenos infecciosos en donantes de sangre, Bolívar-Colombia, 2006-2010

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