The Direction of Innovation of Antibacterial Agents in Preventing Wounds Infection: A Systematic Review

Abstract

Skin is a part of the body that serves to protect other body parts in it. Wounds are a disruption of skin integrity, as well as a threat to the security of the body, especially from the risk of infection. The current management of infection has complicated problems that have not been resolved properly, namely bacterial resistance to antibiotics. The discovery of new anti-bacterial substances is one of the keys to preventing delays in wound healing and various complications in wound healing. This type of research is a systematic review, by analysing journals published in 2016-2021 from the science direct and PubMed databases. There were 8 articles analysed to determine the presence of new anti-bacterial active substances that were clinically tested. The results of the analysis showed that there were 6 articles in clinical trials that showed positive results in treating and preventing infection, and 2 with the opposite result. All articles analysed did not present a review of the new antibacterial agent. The researcher concludes that the development of the discovery of new antibacterial substances is slow, because there are no clinical trials of new antibacterial active ingredients in wound dressings in the 2016-2021 period, although there is one prospective method to be developed, namely bacterial binding dressing.