It has been suggested that the adverse metabolic effects of thiazide and β‐adrenoceptor blockers may explain their failure to alter significantly the death rate from coronary heart disease in hypertensive patients.
Because of their increasing use, the metabolic effects of calcium antagonists are of importance. Although there are a number of case reports of hyperglycaemia with nifedipine, larger studies with it and nicardipine in diabetics do not show significant deterioration in diabetic control.
Neither nicardipine nor nifedipine appear to alter total cholesterol or urate levels and hypokalaemia has not been reported.
While verapamil may acutely alter pituitary function, more detailed studies with nicardipine and nifedipine have found no significant effect on pituitary or thyroid function.
To date the dihydropyridine calcium antagonists, nicardipine and nifedipine, appear remarkably free of adverse metabolic or endocrine effects.