The diffusion and bulk properties of polyurethane (PU) ‐based hydrophilic and hydrophobic membranes

Pulat, Mehlíka; Akdoğan, Ayten

doi:10.1002/app.10596

Cited by 18 publications

(16 citation statements)

References 27 publications

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“…Its release control can be due biomembrane hydrophobicity 21 . These results were also obtained by Giri et al 22 which acrylic acid grafted guargum-nanosilica biomembrane provided excellent control over diclofenac releases, as well as by Pulat et al 23 that showed that PU (hydrophobic) membranes had a slower release than hydrophilic ones. This may be due hydrophobic membranes do not lead to void volume between molecules, hampering the diffusion through membrane.…”

Section: Resultssupporting

confidence: 64%

Evaluation of sodium diclofenac release using natural rubber latex as carrier

et al. 2014

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Sodium Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) taken to reduce inflammation and, as an analgesic, reduce pain. Although this drug is widely used in the general population, properties such as the short half-time and some side effects restrict its clinical use. The most common side effects are: gastric irritation, gastritis, peptic ulcer and bleeding. Studies involving biomaterials as carrier for drug release have been proving their efficiency in overcoming those problems and better controling the release rate and targeting of the drug. Natural rubber latex (NRL) has been proven excellent for its biocompatibility and ability to stimulate angiogenesis, cellular adhesion and the formation of extracellular matrix, promoting the replacement and regeneration of tissue. In this work, a NRL membrane is used to deliver sodium diclofenac. Sodium diclofenac (NaDic) was found to be adsorbed on the NRL membrane, with little or no incorporation into the membrane bulk, according to energy dispersive Scanning Electron Microscopy with X-Ray microanalysis (SEM-EDS) spectroscopy. In addition, FT-IR shows that there is no molecular-level interaction between drug and NRL. Already, the X-Ray Diffraction (XRD) of NaDic-NRL shows a broader one spectrum than the sharper halo (amorphous characteristic XRD spectrum) of pure NRL. More importantly, the release time of diclofenac in a NRL membrane in vitro was increased from the typical 2-3 h for oral tablets to ca. 74 h. The kinetics of the drug release could be fitted with a double exponential function, with two characteristic times of 0.899 and 32.102 h. In this study, we demonstrated that the interesting properties provided by NRL membranes combined with a controlled release of drug is relevant for biomedical applications.

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Section: Resultssupporting

confidence: 64%

Evaluation of sodium diclofenac release using natural rubber latex as carrier

et al. 2014

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“…Since the dissociation constants are very close to each other, the consecutive swellings at these pH values overlap and only single-step swelling versus pH curves are observed [19,34]. As the swelling values of PAA and PAACA hydrogels exhibit greater differences between pH ¼ 2.0 and 8.0, these hydrogels are more sensitive to the variations in pH in this range [18,21,35].…”

Section: Swelling Behaviors Of Hydrogelsmentioning

confidence: 99%

Pantoprazole-Na Release from Poly(acrylamide-co-crotonic acid) and Poly(acrylic acid-co-crotonic acid) Hydrogels

Pulat

Çetin

2008

Journal of Bioactive and Compatible Polymers

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Poly(acrylamide-co-crotonic acid) (PAAmCA), poly(acrylic acidco-crotonic acid) (PAACA), PAA and PAAm hydrogels were prepared by free radical polymerization and ethylene glycol dimethacrylate (EGDMA) as a crosslinker. The variations of swelling values (%) with time, temperature, and pH were determined for four types of hydrogels. The PAACA hydrogel was swollen 2300% at pH ¼ 7.4 and 378C. The drug release from pantoprazole-Na loaded PAACA and PAAmCA hydrogels was followed at pH ¼ 7.4, 378C for 30 h. The release from PAACA hydrogel was faster than that from PAAmCA hydrogel; therapeutic levels for both hydrogels are obtained within 1 hour. Non-Fickian diffusion was determined for both hydrogels.

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“…In general, it is known that the materials for the hemodialysis membrane should have excellent blood compatibility, chemical resistance, high mechanical strength, and good transport properties (Krause et al, 2003). Therefore, we have employed both PU and PES as candidate membrane materials because the two materials satisfy hemodialysis-membrane requirements and they are broadly used in the biomedical fields (PES is used as a material in current hemodialyzer membranes, while PU is used in blood-contact components of artificial hearts) (Baik et al, 1999;Pulat and Akdogan, 2002).…”

Section: Introductionmentioning

confidence: 99%

Polymeric nanofiber web-based artificial renal microfluidic chip

Lee

Kim

Min

et al. 2007

Biomed Microdevices

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In this paper, we present a new method for the creation of a smaller dialyzer and do so by incorporating polymeric nanofiber web, which is known to have good filtration efficiency for broad particle sizes, into a poly (dimethylsiloxane)-based microplatform. We have developed a process that makes possible the efficient production of polyethersulfone and polyurethane nanofiber web and that, itself, incorporates an electrospinning method. We have combined the nanofiber web with the PDMS-based microfluidic platform to create a chip-based portable hemodialysis system. With the dialyzing chip, we evaluated the filtration capability of molecules in broad ranges of sizes and compared the filtration capability of nanofiber membranes with that of PES and polyvinylidene fluoride porous membranes (sheet type): we discovered that the nanofiber membranes have better filtration performance than the other membranes. Blood cells were not mechanically affected during their filtration and their transportation through the chip. In conclusion, we have demonstrated the feasibility of chip-based hemodialysis, and we expect that our method suggested in this paper will be applied to the development of small light-weight dialyzers for the realization of portable hemodialysis systems.

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The diffusion and bulk properties of polyurethane (PU) ‐based hydrophilic and hydrophobic membranes

Cited by 18 publications

References 27 publications

Evaluation of sodium diclofenac release using natural rubber latex as carrier

Evaluation of sodium diclofenac release using natural rubber latex as carrier

Pantoprazole-Na Release from Poly(acrylamide-co-crotonic acid) and Poly(acrylic acid-co-crotonic acid) Hydrogels

Polymeric nanofiber web-based artificial renal microfluidic chip

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