The Differentiating Intestinal Epithelial Cell: Establishment and Maintenance of Functions Through Interactions Between Cellular Structures

Louvard, Daniel; Kédinger, Michèle; Hauri, Hans Peter

doi:10.1146/annurev.cb.08.110192.001105

Cited by 241 publications

(156 citation statements)

References 73 publications

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“…However, both in HT-29 and Caco-2 cells, the time course of the differentiation process closely mimics the situation found in the small intestine [20]. There is a particular situation in the intestine due to rapid epithelial cell renewal, with proliferating cells being undifferentiated and with the differentiation occurring during the crypt to villus migration of non-dividing cells [43,44]. The results of this study strongly suggest that L. monocytogenes may preferentially enter crypt cells of the intestine in vivo by a microfilament-dependent process involving the bacterial inZAB locus.…”

Section: Discussionmentioning

confidence: 52%

Cell proliferation enhances entry of Listeria monocytogenes into intestinal epithelial cells by two proliferation-dependent entry pathways

Velge

Bottreau

Van-Langendonck

et al. 1997

Journal of Medical Microbiology

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Bacterial entry into intestinal host cells is the result of a fairly sophisticated manipulation of host cell machinery by the pathogens. To study further the potential cell target of Listeria spp., the in-vitro entry of L. monocytogenes strains into intestinal cells was examined in relation to the metabolism, proliferation and differentiation of the cells by the alamarBlue assay, [3H] thymidine incorporation, and brush borderassociated enzyme activities, respectively. The study showed that cell metabolism was not involved in the entry of L. monocytogenes in three cell models (two human and one porcine). On the other hand, entry was closely related to the proliferation process and poorly related to the differentiation state of the cells. The use of L. monocytogenes mutants lacking invasion proteins showed that InlA and InlB acted in synergy to mediate the entry of L. monocytogenes into proliferative cells, whereas InlA alone seemed to be involved in the entry into non-proliferative cells. These two entry pathways could correspond to the two cellular processes used by L. monocytogenes to enter proliferative and non-proliferative cells, as suggested by the use of cytochalasin D, nocodazole, chloroquine and monodansylcadaverine. Taken together, we propose a hypothesis in which the entry of L. monocytogenes is mediated by interaction between randomly distributed E-cadherin on the surface of proliferative cells. In contrast, the entry into non-proliferative cells may involve pp60c'src, a proto-oncogenic tyrosine kinase signal that modifies E-cadherin localisation. In conclusion, these results suggest that L. monocytogenes may preferentially enter crypt cells in vivo by a microfilament-dependent process, whereas the few bacteria that infect villus cells enter by an E-cadherininternalin interaction that mediates microtubule-dependent endocytosis.

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Section: Discussionmentioning

confidence: 52%

Cell proliferation enhances entry of Listeria monocytogenes into intestinal epithelial cells by two proliferation-dependent entry pathways

Velge

Bottreau

Van-Langendonck

et al. 1997

Journal of Medical Microbiology

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“…In the avian and mammalian digestive tract, it has been amply shown that epithelial-mesenchymal or connective tissue interactions occur during the embryonic organogenesis and the postembryonic homeostasis (Kedinger et al, 1988;Louvard et al, 1992;Yasugi, 1993;Mizuno, 1994), suggesting the existence of common key signaling pathways for such interactions. Indeed, the Shh/BMP-4 signaling pathway shown to be involved in the amphibian intestinal remodeling has also been proposed to play roles in the embryonic gut organogenesis of terrestrial vertebrates (Roberts, 2000;Zhang et al, 2001; and the postembryonic epithelial cell-renewal of the mammalian intestine (Howe et al, 2001;Madison et al, 2004;Haramis et al, 2004;He et al, 2004He et al, , 2007Batts et al, 2006).…”

Section: Perspectivesmentioning

confidence: 99%

Regulation of adult intestinal epithelial stem cell development by thyroid hormone during Xenopus laevis metamorphosis

Ishizuya‐Oka

Shi

2007

Developmental Dynamics

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During amphibian metamorphosis, most or all of the larval intestinal epithelial cells undergo apoptosis. In contrast, stem cells of yet-unknown origin actively proliferate and, under the influence of the connective tissue, differentiate into the adult epithelium analogous to the mammalian counterpart. Thus, amphibian intestinal remodeling is useful for studying the stem cell niche, the clarification of which is urgently needed for regenerative therapies. This review highlights the molecular aspects of the niche using the Xenopus laevis intestine as a model. Because amphibian metamorphosis is completely controlled by thyroid hormone (TH), the analysis of TH response genes serves as a powerful means for clarifying its molecular mechanisms. Although functional analysis of the genes is still on the way, recent progresses in organ culture and transgenic studies have gradually uncovered important roles of cell-cell and cell-extracellular matrix interactions through stromelysin-3 and sonic hedgehog/bone morphogenetic protein-4 signaling pathway in the epithelial stem cell development. Developmental Dynamics 236:3358 -3368, 2007.

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“…Important cellular processes involve cell protrusions, including nutrient resorption (Louvard et al, 1992), mechanosensing (Frolenkov et al, 2004), photosensing (Corbeil et al, 2001;Pellikka et al, 2002), establishment of cell adhesion (Vasioukhin et al, 2000), cell migration (Fulga and Rorth, 2002), fusion of epithelial sheets (Jacinto et al, 2000;MartinBlanco et al, 2000), wound healing (Wood et al, 2002), axon guidance (Ritzenthaler et al, 2000), and cell-tocell communication (reviewed in Rorth, 2003). Intercellular communication is important for the growth and patterning of tissues and organs and cell protrusions may mediate this communication by one of several mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Apical and lateral cell protrusions interconnect epithelial cells in live Drosophila wing imaginal discs

Demontis

Dahmann

2007

Developmental Dynamics

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The Differentiating Intestinal Epithelial Cell: Establishment and Maintenance of Functions Through Interactions Between Cellular Structures

Cited by 241 publications

References 73 publications

Cell proliferation enhances entry of Listeria monocytogenes into intestinal epithelial cells by two proliferation-dependent entry pathways

Cell proliferation enhances entry of Listeria monocytogenes into intestinal epithelial cells by two proliferation-dependent entry pathways

Regulation of adult intestinal epithelial stem cell development by thyroid hormone during Xenopus laevis metamorphosis

Apical and lateral cell protrusions interconnect epithelial cells in live Drosophila wing imaginal discs

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