The Differentially Expressed Circular RNAs in the Substantia Nigra and Corpus Striatum of Nrf2-Knockout Mice

Yang, Junhui; Zhang, Runjiao; Lin, Jiajie; Cao, Ming-Chao; Wang, Qie; Cui, Huixian; Sun, Shao-Guang; Wang, Lei

doi:10.1159/000494478

Cited by 18 publications

(11 citation statements)

References 51 publications

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“…Altogether, we speculate that mmu_circRNA_33836, mmu_circRNA_008691, mmu_circRNA_45901 andmmu_circRNA_34137 may play a central role in learning and memory. Importantly, in our previous study, mmu_circRNA_33836 and mmu_circRNA_34137 were down-regulated in the substantia nigra and corpus striatum between Nrf2 (−/−) and Nrf2 (+/+) mice, and this consistent result emphasized the critical function of mmu_circRNA_33836 and mmu_circRNA_34137 in Nrf2-mediated neuroprotection (Yang et al, 2018).…”

Section: Discussionsupporting

confidence: 57%

“…In our previous study, we detected the altered expression of circRNAs and lncRNAs in the substantia nigra and corpus striatum tissue of Nrf2-null mice (Liu J. et al, 2017; Yang et al, 2018), and considering that Nrf2 activity may diverge across different brain regions, the current study focused on the expression profiles of circRNAs and lncRNAs in the hippocampus tissue of Nrf2-null mice. Previous studies showed definitively that the hippocampus and neighboring structures of the medial temporal lobe are essential to memory (Preston and Eichenbaum, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Differential Expression Profiles and Functional Prediction of Circular RNAs and Long Non-coding RNAs in the Hippocampus of Nrf2-Knockout Mice

Zhang

Liu

et al. 2019

Front. Mol. Neurosci.

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Background Nrf2 (nuclear factor, erythroid 2 like 2) is believed to play a major role in neurodegenerative diseases. The present study attempts to investigate the hippocampal circRNA and lncRNA expression profiles associated with Nrf2-mediated neuroprotection. Methods The hippocampal mRNA, circRNA and lncRNA expression profiles of Nrf2 (−/−) mice were determined by a microarray analysis. Bioinformatics analyses, including identification of differentially expressed mRNAs (DEmRNAs), circRNAs (DEcircRNAs) and lncRNAs (DElncRNAs), DEcircRNA-miRNA-DEmRNA interaction network construction, DElncRNA-DEmRNA co-expression network construction, and biological function annotation, were conducted. Quantitative real-time polymerase chain reaction (qRT-PCR) was performed to validate the dysregulated expression of circRNAs and lncRNAs derived from the microarray data of the hippocampus of Nrf2 (−/−) mice. Results Compared to wild-type Nrf2 (+/+) mice, 412 DEmRNAs (109 up- and 303 down-regulated mRNAs), 1279 DEcircRNAs (632 up- and 647 down-regulated circRNAs), and 303 DElncRNAs (50 up- and 253 down-regulated lncRNAs) were identified in the hippocampus of Nrf2 (−/−) mice. Additionally, in the qRT-PCR validation results, the expression patterns of selected DEcircRNAs and DElncRNAs were generally consistent with results in the microarray data. The DEcircRNA-miRNA-DEmRNA interaction networks revealed that mmu_circRNA_44531, mmu_circRNA_34132, mmu_circRNA_000903, mmu_circRNA_018676, mmu_circRNA_45901, mmu_circRNA_33836, mmu_circRNA_ 34137, mmu_circRNA_34106, mmu_circRNA_008691, and mmu_circRNA_003237 were predicted to compete with 47, 54, 45, 57, 63, 81, 121, 85, 181, and 43 DEmRNAs, respectively. ENSMUST00000125413, NR_028123, uc008nfy.1, AK076764, AK142725, AK080547, and AK035903 were co-expressed with 178, 89, 149, 179, 142, 55, and 112 DEmRNAs in the Nrf2 (−/−) hippocampus, respectively. Conclusion Our study might contribute to exploring the key circRNAs and lncRNAs associated with Nrf2-mediated neuroprotection.

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Section: Discussionsupporting

confidence: 57%

Section: Introductionmentioning

confidence: 99%

Differential Expression Profiles and Functional Prediction of Circular RNAs and Long Non-coding RNAs in the Hippocampus of Nrf2-Knockout Mice

Zhang

Liu

et al. 2019

Front. Mol. Neurosci.

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“…So reduction-oxidation (redox) homeostasis is a crucial component of cancer metabolism. Some studies demonstrated that several circRNAs were differentially expressed in substantia nigra and corpus striatum of NRF2 knock-out mice compared with the control group [73]. Increases CircNCX1 in response to ROS in cardiomyocytes could sponge miR-133a-3p to release the pro-apoptotic gene CDIP1 [74].…”

Section: Main Textmentioning

confidence: 99%

CircRNAs in cancer metabolism: a review

et al. 2019

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Altered energy metabolism is a hallmark of tumors aiming at supplying necessary nutrients for tumorigenesis and development. These redirected metabolic pathways associated with carbohydrate, lipid and amino acid are orchestrated not only by carcinogenic proteins but by non-coding RNAs. Among them, circular RNA (circRNA), as a kind of novel identified non-coding RNAs, has become the focus of attention. Through binding with corresponding microRNAs or directly contacting proteins, circRNA plays a primarily important role in regulating cellular metabolism. Herein, we analyze the emerging findings and select circRNAs contributing to mutant glycolysis, lipogenesis and lipolysis, glutam inolysis, and oxidative respiration to deepen the understanding about the cancer metabolic regulatory network. In addition, we also discuss the possibility of circRNAs exerting their functions via exosomes and cancer stem cells. Owing to their unique structures and wide impacts, circRNAs may help reap huge fruits in developing clinical treatments targeting cancer metabolism.

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“…Furthermore, nuclear factor E2-related factor 2 (Nrf2), a potential therapeutic target for rheumatic diseases, could regulate many biological processes such as inflammation, immune response and cartilage and bone metabolism in the body 89 . By analyzing the circRNA expression profiles in the substantia nigra and corpus striatum of Nrf2-knockout mice, Yang et al 90 found that mmu_circRNA_34132, mmu-circRNA-015216 and mmu_circRNA_017077 were involved in the Nrf2-mediated neuroprotection against oxidative stress. Notably, the authors also uncovered that four mRNAs, Atp6v0a1, Atp6v0b, Atp6v0c, and Atp6v0e2, were enriched in RA pathway in the circRNA-miRNA-mRNA interaction network.…”

Section: Circrnas In Autoimmune Diseasesmentioning

confidence: 99%

Roles of circular RNAs in immune regulation and autoimmune diseases

et al. 2019

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Circular RNAs (circRNAs), as a novel class of endogenously expressed non-coding RNAs (ncRNAs), have a high stability and often present tissue-specific expression and evolutionary conservation. Emerging evidence has suggested that circRNAs play an essential role in complex human pathologies. Notably, circRNAs, important gene modulators in the immune system, are strongly associated with the occurrence and development of autoimmune diseases. Here, we focus on the roles of circRNAs in immune cells and immune regulation, highlighting their potential as biomarkers and biological functions in autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), primary biliary cholangitis (PBC), and psoriasis, aiming at providing new insights into the diagnosis and therapy of these diseases. Facts • CircRNAs are related to various biological processes in immune cells, as well as immune regulation under multifarious physiological and pathological conditions. • CircRNAs serve as potential biomarkers for the diagnosis and severity of certain autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), primary biliary cholangitis (PBC). • CircRNAs contribute to the development of autoimmune diseases by acting as miRNA sponges to regulate many biological processes, including DNA methylation, immune response, and inflammatory response. • Certain circRNAs, such as cia-cGAS and dsRNA-containing circRNAs, may act as potential targets for the treatment of autoimmune diseases.

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The Differentially Expressed Circular RNAs in the Substantia Nigra and Corpus Striatum of Nrf2-Knockout Mice

Cited by 18 publications

References 51 publications

Differential Expression Profiles and Functional Prediction of Circular RNAs and Long Non-coding RNAs in the Hippocampus of Nrf2-Knockout Mice

Differential Expression Profiles and Functional Prediction of Circular RNAs and Long Non-coding RNAs in the Hippocampus of Nrf2-Knockout Mice

CircRNAs in cancer metabolism: a review

Roles of circular RNAs in immune regulation and autoimmune diseases

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