The differential expression patterns of messenger RNAs encoding non-N-methyl-d-aspartate glutamate receptor subunits (GluR1–4) in the rat brain

Sato, Kohji; Kiyama, Hiroshi; Tohyama, Masaya

doi:10.1016/0306-4522(93)90403-3

Cited by 304 publications

(219 citation statements)

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“…In previous work we observed that AMPA receptor-mediated synaptic responses in the hippocampal CA1 pyramidal cells of global Gria1-knockout mice are preserved indicating that, for synaptic transmission, the missing GluA subunits can be substituted by other AMPA receptor subunits (Zamanillo et al, 1999). Dense expression of both Gria2 and Gria4 subunit mRNA and low Gria3 mRNA expression have been reported previously in the ascending raphe nuclei of the midbrain (Gold et al, 1997;Sato et al, 1993). Thus, we hypothesize the enhanced AMPA response observed in 5-HT neurons lacking GLUA1 is mediated by receptors composed of the remaining subunits, which effectively substitute for GLUA1.…”

Section: Mechanisms Underlying the Behavioral Phenotypesupporting

confidence: 65%

“…Gria1 mRNA has been demonstrated in most neuronal populations of the brain including the ascending raphe nuclei (Gold et al, 1997;Sato et al, 1993), but Gria1 mRNA or GLUA1 protein expression specifically in serotonergic neurons has not, as yet, been confirmed. Here we show that in control mice GLUA1 is present in the overwhelming majority of DRN and MRN neurons, which co-label for TPH2 (and hence are presumed to be 5-HT neurons).…”

Section: Evidence For a Selective Loss Of Glua1mentioning

confidence: 96%

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Adult AMPA GLUA1 Receptor Subunit Loss in 5-HT Neurons Results in a Specific Anxiety-Phenotype with Evidence for Dysregulation of 5-HT Neuronal Activity

Weber

Vogt

Gartside

et al. 2014

Neuropsychopharmacol

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Both the glutamatergic and serotonergic (5-HT) systems are implicated in the modulation of mood and anxiety. Descending cortical glutamatergic neurons regulate 5-HT neuronal activity in the midbrain raphe nuclei through a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and N-methyl-D-aspartate (NMDA) receptors. To analyze the functional role of GLUA1-containing AMPA receptors in serotonergic neurons, we used the Cre-ERT2/loxP-system for the conditional inactivation of the GLUA1-encoding Gria1 gene selectively in 5-HT neurons of adult mice. These Gria1 5-HT À / À mice exhibited a distinct anxiety phenotype but showed no alterations in locomotion, depression-like behavior, or learning and memory. Increased anxiety-related behavior was associated with significant decreases in tryptophan hydroxylase 2 (TPH2) expression and activity, and subsequent reductions in tissue levels of 5-HT, its metabolite 5-hydroxyindoleacetic acid (5-HIAA), and norepinephrine in the raphe nuclei. However, TPH2 expression and activity as well as monoamine levels were unchanged in the projection areas of 5-HT neurons. Extracellular electrophysiological recordings of 5-HT neurons revealed that, while a1-adrenoceptor-mediated excitation was unchanged, excitatory responses to AMPA were enhanced and the 5-HT 1A autoreceptor-mediated inhibitory response to 5-HT was attenuated in Gria1 5-HT À / À mice. Our data show that a loss of GLUA1 protein in 5-HT neurons enhances AMPA receptor function and leads to multiple local molecular and neurochemical changes in the raphe nuclei that dysregulate 5-HT neuronal activity and induce anxiety-like behavior.

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Section: Mechanisms Underlying the Behavioral Phenotypesupporting

confidence: 65%

Section: Evidence For a Selective Loss Of Glua1mentioning

confidence: 96%

Adult AMPA GLUA1 Receptor Subunit Loss in 5-HT Neurons Results in a Specific Anxiety-Phenotype with Evidence for Dysregulation of 5-HT Neuronal Activity

Weber

Vogt

Gartside

et al. 2014

Neuropsychopharmacol

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“…Within the NAcc region of the VS, a subterritory, called the shell, has a particularly important function in the circuitry underlying goal-directed behaviors, behavioral sensitization, and changes in affective states (Carlezon and Wise, 1996;Ito et al, 2004). Although several transmitter and receptor distribution patterns distinguish the shell/core subterritories, calbindin is the most consistent marker for the shell across species (Alheid and Heimer, 1988;Ikemoto et al, 1995;Martin et al, 1993;Meredith et al, 1996;Sato et al, 1993). The shell has some unique connectivities that distinguish it from the rest of the VS (indicated below).…”

Section: Organization Of the Vsmentioning

confidence: 99%

The Reward Circuit: Linking Primate Anatomy and Human Imaging

Haber

Knutson

2009

Neuropsychopharmacol

3,053

190

2,767

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Although cells in many brain regions respond to reward, the cortical-basal ganglia circuit is at the heart of the reward system. The key structures in this network are the anterior cingulate cortex, the orbital prefrontal cortex, the ventral striatum, the ventral pallidum, and the midbrain dopamine neurons. In addition, other structures, including the dorsal prefrontal cortex, amygdala, hippocampus, thalamus, and lateral habenular nucleus, and specific brainstem structures such as the pedunculopontine nucleus, and the raphe nucleus, are key components in regulating the reward circuit. Connectivity between these areas forms a complex neural network that mediates different aspects of reward processing. Advances in neuroimaging techniques allow better spatial and temporal resolution. These studies now demonstrate that human functional and structural imaging results map increasingly close to primate anatomy.

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“…The receptors, heterooligomeric proteins composed of the subunits G1uR1 -4 with flip and flop forms (Hollmann and Heinemann, 1994;Bettler and Mulle, 1995;Barnard, 1997), play key roles in CNS physiology and pathology. AMPA receptor subunits G1uR1 -4 are differentially regulated during ontogeny, and in adult rat brain they have only partially overlapping distributions (Keinanen et al, 1990;Monyer et a!., 1991;Hampson et al, 1992;Petralia and Wenthold, 1992;Martin et al, 1993;Sato et a!., 1993;Baude et al, 1994;Bahn and Wisden, 1997;Bernard et al, 1997;Petralia eta!., 1997). The stoichiometries of AMPA receptor subunit mRNAs in rat brain suggest the existence of four classes of receptor complexes (Gold et a!., 1997).…”

mentioning

confidence: 99%

Binding Characteristics of a Potent AMPA Receptor Antagonist [³H]Ro 48‐8587 in Rat Brain

Mutel

Trube

Klingelschmidt

et al. 1998

Journal of Neurochemistry

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The distribution and abundance of specific binding sites (=95% of total) in sections of rat CNS, revealed by quantitative receptor radioautography and image analysis, indicated a very discrete localization. Highest binding values were observed in cortical layers (binding in layers 1 and 2> binding in layers 3-6), hippocampal formation, striatum, dorsal septum, reticular thalamic nucleus, cerebellar molecular layer, and spinal cord dorsal horn. At 1 nM, the values for specific binding were highest in the cortical layers 1 and 2 and lowest in the brainstem (=2.6 and 0.4 pmol/mg of protein, respectively). Ro 48-8587 is a potent and selective AMPA receptor antagonist with improved binding characteristics (higher affinity, selectivity, and specific binding) compared with those previously reported. Key Words: a-Amino-3-hydroxy-5-methylisoxazole-4-propionate-9-lmidazol-1 -yl-8-nitro-2,3, 5,6-tetrahydro- High-affinity a-aniino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors are ligand-gated cation channels for L-glutalnate, the major excitatory transmitter in the mammalian CNS. Their activation mediates fast transmission at glutamatergic synapses. The receptors, heterooligomeric proteins composed of the subunits G1uR1 -4 with flip and flop forms (Hollmann and Heinemann, 1994;Bettler and Mulle, 1995;Barnard, 1997), play key roles in CNS physiology and pathology. AMPA receptor subunits G1uR1 -4 are differentially regulated during ontogeny, and in adult rat brain they have only partially overlapping distributions (Keinanen et al

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The differential expression patterns of messenger RNAs encoding non-N-methyl-d-aspartate glutamate receptor subunits (GluR1–4) in the rat brain

Cited by 304 publications

References 46 publications

Adult AMPA GLUA1 Receptor Subunit Loss in 5-HT Neurons Results in a Specific Anxiety-Phenotype with Evidence for Dysregulation of 5-HT Neuronal Activity

Adult AMPA GLUA1 Receptor Subunit Loss in 5-HT Neurons Results in a Specific Anxiety-Phenotype with Evidence for Dysregulation of 5-HT Neuronal Activity

The Reward Circuit: Linking Primate Anatomy and Human Imaging

Binding Characteristics of a Potent AMPA Receptor Antagonist [³H]Ro 48‐8587 in Rat Brain

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The differential expression patterns of messenger RNAs encoding non-N-methyl-d-aspartate glutamate receptor subunits (GluR1–4) in the rat brain

Cited by 304 publications

References 46 publications

Adult AMPA GLUA1 Receptor Subunit Loss in 5-HT Neurons Results in a Specific Anxiety-Phenotype with Evidence for Dysregulation of 5-HT Neuronal Activity

Adult AMPA GLUA1 Receptor Subunit Loss in 5-HT Neurons Results in a Specific Anxiety-Phenotype with Evidence for Dysregulation of 5-HT Neuronal Activity

The Reward Circuit: Linking Primate Anatomy and Human Imaging

Binding Characteristics of a Potent AMPA Receptor Antagonist [3H]Ro 48‐8587 in Rat Brain

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Binding Characteristics of a Potent AMPA Receptor Antagonist [³H]Ro 48‐8587 in Rat Brain