The Different Classes of Proteic and Peptidic Substances Present in the Pineal Gland

Pévet, Paul

doi:10.1007/978-1-4757-1451-7_7

Cited by 26 publications

(26 citation statements)

References 85 publications

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“…5). It has been shown that GnRH receptor is present in the monkey pineal gland (3), that GnRH influences the activity of protein synthesis in rat pinealocytes (17) and that administration of GnRHa to women increases nocturnal serum melatonin concentrations (18), suggesting that GnRH may participate in the modulation of melatonin production. Vacas et al (22) Table 2 Effect of administration of GnRHa on serum estradiol in 65-day-old female rats at the time of decapitation.…”

Section: Discussionmentioning

confidence: 99%

“…Although mammalian melatonin production is mainly controlled by the photoperiod through a noradrenergic mechanism (1,2), evidence suggests that circulating concentrations of reproductive hormones influence pineal indole metabolism (3)(4)(5). Sex steroid receptors have been identified in the rat pineal gland (6).…”

Section: Introductionmentioning

confidence: 99%

“…Gonadotropin-releasing hormone (GnRH) receptors have been identified in the monkey pineal gland (3), and GnRH influences the activity of protein synthesis in rat pinealocytes (17). In addition, administration of GnRH agonist (GnRHa) to women increases nocturnal serum melatonin concentrations (18).…”

Section: Introductionmentioning

confidence: 99%

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Melatonin secretion from organ-cultured pineal glands of rats: modulation by gonadectomy and gonadotropin-releasing hormone agonist administration

Ishizuka

Fusama²,

Hirai³

et al. 2000

European Journal of Endocrinology

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The objective of the study was to evaluate the effect of pretreatments such as gonadectomy in male and female rats, and gonadotropin-releasing hormone agonist (GnRHa) administration in female rats, on levels of secretion of melatonin, using an organ culture of pineal glands. Gonadectomy 2 weeks before the animal was killed increased the amount of melatonin secreted into the medium by the pineal glands of female rats but not of male rats. The increase in in vitro melatonin secretion after ovariectomy in female rats was prevented by estrogen replacement. Ovariectomy 3 and 4 weeks before death also significantly increased the amount of melatonin secretion. Administration of GnRHa 2 weeks before decapitation significantly decreased serum estradiol concentrations and significantly increased melatonin secretion by the pineal glands of female rat. GnRHa administration 3 or 4 weeks before decapitation also significantly decreased serum estradiol concentrations, but did not increase pineal secretion of melatonin. The results indicate that ovariectomy increases melatonin secretion from organ-cultured pineal glands and that this increase is suppressed by estrogen in adult female rats. In contrast, orchiectomy in male rats does not influence in vitro secretion of melatonin. These results suggest that the GnRH-gonadotropin system may participate in the regulation of pineal melatonin secretion in adult female rats.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Melatonin secretion from organ-cultured pineal glands of rats: modulation by gonadectomy and gonadotropin-releasing hormone agonist administration

Ishizuka

Fusama²,

Hirai³

et al. 2000

European Journal of Endocrinology

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“…These studies have brought few satisfactory results (see Pévet, 1981Pévet, , 1983bVaughan, 1984 for reviews). A decapeptide isolated from the bovine pineal gland has been characterized for its inhibitory effect on prolactin secretion and luteinizing hormone pulses (Benson and Ebels, 1994;Benson et al, 1996).…”

Section: Paracrine Inputsmentioning

confidence: 99%

“…Seventeen years later, this introduction to the control of MEL production in mammals remains truer than ever. Pévet (1981Pévet ( , 1983bPévet ( , 1986) was one of the first authors to point out the large variety of peptides contained in the mammalian pineal gland. Before this, studies had focused on the search for a specific pineal peptide with antigonadotropic properties.…”

Section: Multiple Regulation Of Pineal Melatonin Synthesis In Mammalsmentioning

confidence: 99%

Generation of the Melatonin Endocrine Message in Mammals: A Review of the Complex Regulation of Melatonin Synthesis by Norepinephrine, Peptides, and Other Pineal Transmitters

2003

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Buffalo (Bubalus bubalis) epiphyseal proteins give protection from arsenic and fluoride‐induced adverse changes in acetylcholinesterase activity in rats

Bharti¹,

Srivastava²,

Anand³

et al. 2011

J Biochem & Molecular Tox

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The objective of this study was to determine the effect of fluoride (F) and arsenic (As) on the activity of acetylcholinesterase (AChE), a critically important nervous system enzyme, and to test the protective role of buffalo epiphyseal (pineal) proteins (BEP) in rats. Arsenic (20 mg/kg BW, intraperitoneally) and F (150 ppm, perorally) were exposed, and BEP was administered intraperitoneally (100 μ g/kg BW) along with F and As to rats for 7 days. As and F exposure significantly (p < 0.05) increased their levels in plasma and decreased the activity of AChE in plasma, RBCs, heart, and brain of rats. Interestingly, As- and F-induced inhibition of AChE activities increased As and F levels in plasma, and organs were significantly (p < 0.05) counteracted by BEP administration. These findings indicate the protective role of buffalo (Bubalus bubalis) epiphyseal proteins on F- and As-induced adverse changes in AChE activity as a candidate biomarker for neurotoxicity in female rats.

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The Different Classes of Proteic and Peptidic Substances Present in the Pineal Gland

Cited by 26 publications

References 85 publications

Melatonin secretion from organ-cultured pineal glands of rats: modulation by gonadectomy and gonadotropin-releasing hormone agonist administration

Melatonin secretion from organ-cultured pineal glands of rats: modulation by gonadectomy and gonadotropin-releasing hormone agonist administration

Generation of the Melatonin Endocrine Message in Mammals: A Review of the Complex Regulation of Melatonin Synthesis by Norepinephrine, Peptides, and Other Pineal Transmitters

Buffalo (Bubalus bubalis) epiphyseal proteins give protection from arsenic and fluoride‐induced adverse changes in acetylcholinesterase activity in rats

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