Buffalo (<i>Bubalus bubalis</i>) epiphyseal proteins give protection from arsenic and fluoride‐induced adverse changes in acetylcholinesterase activity in rats

Bharti, Vijay K.; Srivastava, R.C.; Anand, Amitesh; Kushwah, Kusum

doi:10.1002/jbt.20407

Cited by 15 publications

(3 citation statements)

References 27 publications

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“…The inhibition of AChE activity in as toxicity due to the free radical generation and oxidative stress induced ill effects were already reported by Bharti et al, (2012). The data obtained from this study clearly show that as significantly decreased the activity of AChE in plasma of rats.…”

Section: Discussionsupporting

confidence: 81%

Defensive role of silibinin against arsenic induced oxidative stress mediated dyslipidemia and neurotoxicity in rats

Muthu

Chanu

Shagirtha³

et al. 2016

IJPT

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Arsenic (As) is an environmental toxic metalloid that is present in everywhere such as air, water and soil. Generally, inorganic arsenic has a tendency to be more toxic than organic arsenic. The present study was designed to determine whether oral administration of silibinin (SB), which has been shown to have substantial antioxidant properties, when pre-administered (75 mg/kg body weight) once daily for 4 weeks along with arsenic (5 mg/kg) would prevent arsenic-induced changes in antioxidant defense system, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX),glutathione-S-transferase (GST),glutathione reductase (GR), glucose-6-phosphate dehydrogenase (G6PD), reduced glutathione (GSH), total sulfhydryl groups (TSH) and vitamin C in rat brain regions such as cortex, striatum, cerebellum, hippocampus and brain stem. Our study also examined the effect of SB over arsenic-induced reactive oxygen species (ROS) production and lipid peroxidation level (LPO) and protein carbonyl content (PC) in distinct brain regions of rats. Moreover, As also alters the lipid profiles such as total lipids, phospholipids, cholesterol, cerebrosides and gangliosides in various regions of the brain. Pre-administration of SB restores the altered enzymatic and non-enzymatic antioxidants, lipid profiles and also markedly reduced the ROS, LPO, PC and accumulation of As in various regions of the brain. These results suggested that arsenic-induced deficits in antioxidant enzyme activities and increase in ROS production and lipid peroxidation levels in brain regions can be remarkably prevented by pre-administration of SB.

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Section: Discussionsupporting

confidence: 81%

Defensive role of silibinin against arsenic induced oxidative stress mediated dyslipidemia and neurotoxicity in rats

Muthu

Chanu

Shagirtha³

et al. 2016

IJPT

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“…In addition, fluoride may affect the activity of some enzymes in the brain. Bharti et al (2012) confirmed that Fsignificantly reduces acetylcholine esterase (AchE) content in rat brain. Degroot et al, (2002) found that AchE can inhibit the formation of physostigmine in either the dorsal or the ventral hippocampus, resulting in increased exploratory behavior in the open arm elevated-plus maze, which was in accordance with the findings of Liu et al, (2014).…”

Section: Brain Damagementioning

confidence: 72%

Fluoride: Its Implications for Public Health

Alvarado¹,

Ceruelos²,

Juárez³

et al. 2018

Preprint

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The use of fluoride (F-) for decreasing the prevalence and incidence of tooth decay was the greatest worldwide preventive public health measure of the 20th century. There have been controversial reports about the benefits of the use of F-, because in small amounts it helps prevent dental caries, but in high concentrations it can be potentially toxic and harmful to dental and systemic health. Since the mid-20th century, F- has been studied by toxicologists, looking at its deleterious effects in human populations. During the last decade, the interest on the undesirable effects has resurfaced because of the knowledge that it interacts with the cellular system, even in low doses, with a very small safety margin. Acute ingestion of toxic amounts of fluoride can cause corrosive gastric mucosa injury. Also respiratory effects such as bleeding, pulmonary edema, tracheostomy and shortness of breath, have been observed in individuals who inhale hydrogen fluoride. Some researchers had shown that F- is an oxidizing agent and a well-known reversible enzymatic inhibitor that interferes with the enzyme activity of at least 80 proteins, can altered the intracellular redox equilibrium, lipid peroxidation, as well as, alteration in the gene expression and apoptosis induction. The primary purpose of this review is to examine findings of the action of inorganic F-, and an overview of hard and soft tissue disturbances, known as fluorosis. The goal of this review is to enhance understanding of the mechanisms by which F- affects cells with an emphasis on human tissue-specific events.

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“…A range of studies revealed that human and animal exposure to different levels of arsenic causing acute, sub-acute and chronic toxicity in animals (Bharti and Srivastava 2009;Bharti et al 2012a; and humans and affects their body physiology and health (Tchounwou et al, 2019;Alvarado-Flores et al, 2019). The latest global number of people infected with arsenicosis, which exceeds the World Health Organization's (WHO's) safe standard for drinking water by 10 ppb, is around 230 million, which has increased dramatically in a decade (Shaji et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Recent advancements in toxicology, modern technology for detection, and remedial measures for arsenic exposure: review

Kumari

Bharti

2022

Biotechnology and Genetic Engineering Reviews

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Arsenic toxicity is an important worldwide health problem of humans and animals due to environmental and occupational exposure through arsenic polluted water, air, soil and food items. It has a multifaceted health impact on animals, human beings, and the environment. Therefore, various experimental and clinical studies were undertaken and had been undergoing to understand its pathogenesis, identify the key biomarkers, medical and economic impact on the affected populations, timely detection and amelioration. However, despite these long-investigated studies, no conclusive information is available for prevention and control of arsenic toxicity, mainly due to complex epidemiology, scattered approach, and repetitive work. Hence, there is a need for literature that exclusively brings information on epidemiology, pathogenesis, and ameliorative measures of arsenic toxicity, which can help researchers and policymakers for effective future planning research and community control programs. In the above view, this article presents an extensive review on the current understanding of arsenic toxicity, detection methodologies, epidemiology, and remedial measures for the bene ts of researchers, academicians, and policy makers in controlling arsenic eco-toxicology and direction for direction futuristic research.

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Buffalo (Bubalus bubalis) epiphyseal proteins give protection from arsenic and fluoride‐induced adverse changes in acetylcholinesterase activity in rats

Cited by 15 publications

References 27 publications

Defensive role of silibinin against arsenic induced oxidative stress mediated dyslipidemia and neurotoxicity in rats

Defensive role of silibinin against arsenic induced oxidative stress mediated dyslipidemia and neurotoxicity in rats

Fluoride: Its Implications for Public Health

Recent advancements in toxicology, modern technology for detection, and remedial measures for arsenic exposure: review

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