Recent advancements in toxicology, modern technology for detection, and remedial measures for arsenic exposure: review

Abstract

Arsenic toxicity is an important worldwide health problem of humans and animals due to environmental and occupational exposure through arsenic polluted water, air, soil and food items. It has a multifaceted health impact on animals, human beings, and the environment. Therefore, various experimental and clinical studies were undertaken and had been undergoing to understand its pathogenesis, identify the key biomarkers, medical and economic impact on the affected populations, timely detection and amelioration. However, despite these long-investigated studies, no conclusive information is available for prevention and control of arsenic toxicity, mainly due to complex epidemiology, scattered approach, and repetitive work. Hence, there is a need for literature that exclusively brings information on epidemiology, pathogenesis, and ameliorative measures of arsenic toxicity, which can help researchers and policymakers for effective future planning research and community control programs. In the above view, this article presents an extensive review on the current understanding of arsenic toxicity, detection methodologies, epidemiology, and remedial measures for the bene ts of researchers, academicians, and policy makers in controlling arsenic eco-toxicology and direction for direction futuristic research.

Mitochondria in the Spotlight: C. elegans as a Model Organism to Evaluate Xenobiotic-Induced Dysfunction

“…Arsenic (As) is a metalloid that is widely present in the environment due to geologic and anthropogenic sources. This element is recognized as an important toxicant, with As ranked as the first substance in the Hazardous Substance Priority List established by the US ATSDR [74]. Moreover, it is recognized as a carcinogenic and genotoxic element [75,76].…”