The differences between aromatizable and non-aromatizable androgens in relation to body composition and metabolic syndrome risk factors in men

Pospíšilová, Hana; Vaňková, Markéta; Hill, Martin; Meloun, Milan; Bendlová, Běla; Dušková, Michaela; Stárka, L.

doi:10.1016/j.jsbmb.2012.02.005

Cited by 10 publications

(6 citation statements)

References 39 publications

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“…It may be due to the relatively high proportion of androgens to estrogens in leaner males. Studies show that total testosterone and dihydrotestosterone in males correlates inversely with visceral and subcutaneous adipose tissue (Nielsen et al, 2007), as well as with BMI (Pospisilova et al, 2012). This result supports the view that males with a lower BMI who have a higher level of testosterone can also afford high immunocompetence.…”

Section: Discussionsupporting

confidence: 62%

Human body morphology, prevalence of nasopharyngeal potential bacterial pathogens, and immunocompetence handicap principal

Pawłowski

Nowak

Borkowska

et al. 2014

American J Hum Biol

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Section: Discussionsupporting

confidence: 62%

Human body morphology, prevalence of nasopharyngeal potential bacterial pathogens, and immunocompetence handicap principal

Pawłowski

Nowak

Borkowska

et al. 2014

American J Hum Biol

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“…In contrast, other studies documented low level of circulating zinc in women with PCOS [8,20]. It is worth mentioning that zinc supplementation (through many mechanisms) has proved to improve the clinical outcomes in women with PCOS [28,29].…”

Section: Discussionmentioning

confidence: 99%

Serum Level of Zinc and Copper in Sudanese Women with Polycystic Ovarian Syndrome

Sharif

Adam

Ahmed

et al. 2017

Biol Trace Elem Res

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The study aimed to evaluate the serum level of zinc and copper in women with polycystic ovarian syndrome (PCOS). A case-control study was conducted at Saad Abualila infertility center (Khartoum, Sudan). The cases were women who had a PCOS based on Rotterdam criteria. The controls were infertile women with no evidence of PCOS. The socio-demographic characteristics and medical history data were gathered using questionnaires. Zinc and copper levels were measured using atomic absorption spectrophotometer. While there was no difference in zinc and copper levels between the two groups (50 women in each arm), mean (SD) of body mass index (BMI) was significantly higher in women with PCOS compared to the controls [28.4 (4.2) vs. 25.6 (5.7) kg/m; P = 0.006], respectively. There were no significant differences in the level of luteinizing hormone (LH), follicle stimulating hormone (FSH), LH/FSH, prolactin, testosterone, cholesterol, triglycerides and low-density lipoprotein (LDL) between the cases and the controls. In linear regression analyses, none of the investigated factors were associated with PCOS. Zinc and copper were not associated with PCOS in this setting.

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“…On the other hand, an impaired lipid profile has also been described in patients with testosterone deficiency. A negative correlation between testosterone and/or DHT levels and lipid fractions has also been demonstrated [18,89]. Testosterone deficiency has been found to be associated with dyslipidemia [90,91] and so can predict the development of an adverse lipid profile [92].…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, the literature provides strong evidence of a link between testosterone deficiency and abnormalities in the glucose and insulin profile. An association between testosterone and/or DHT deficiency and impaired FG, insulin resistance and diabetes mellitus has emerged in several studies [18,89,90,91,102], and testosterone deficiency has been shown to predict the development of diabetes mellitus [19,26,103]. Men with chronic androgen deficiency due to Klinefelter's syndrome and idiopathic hypogonadotropic hypogonadism exhibit significantly higher steady-state plasma glucose concentrations upon an oral glucose load as compared to healthy control subjects [19], with glucose and insulin levels being almost doubled in comparison with controls [19].…”

Section: Discussionmentioning

confidence: 99%

Effect of Chronic Cabergoline Treatment and Testosterone Replacement on Metabolism in Male Patients with Prolactinomas

et al. 2015

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Introduction: Hyperprolactinemia and hypogonadism are reportedly associated with an impaired metabolic profile. The current study aimed at investigating the effects of testosterone replacement and cabergoline (CAB) treatment on the metabolic profile in male hyperprolactinemic patients. Patients and Methods: Thirty-two men with prolactinomas, including 22 with total testosterone (TT) <8 nmol/l (HG, 69%) and 10 with TT >8 nmol/l (non-HG, 31%), were entered in the study. In all patients, metabolic parameters were assessed at diagnosis and after 12- and 24-month treatment. Results: Compared to non-HG patients, at baseline the HG patients had higher waist circumference (WC). TT significantly correlated with body mass index (BMI). Twelve-month CAB induced PRL normalization in 84%. HG prevalence significantly decreased (28%) and non-HG prevalence significantly increased (72%). Anthropometric and lipid parameters, fasting insulin (FI), insulin sensitivity index (ISI₀), homeostatic model assessment of insulin secretion (HOMA-β) and homeostatic model assessment of insulin resistance (HOMA-IR) significantly improved compared to baseline. TT was the best predictor for FI. Percent change (Δ) of TT significantly correlated with ΔCholesterol, ΔWeight and ΔBMI. Compared to non-HG patients, the HG patients had a higher weight, BMI, WC and HOMA-β. In HG, testosterone replacement was started. After 24 months, PRL normalized in 97%. HG prevalence significantly decreased (6%) and non-HG prevalence significantly increased (94%). Anthropometric and lipid parameters, FI, ISI₀, HOMA-β and HOMA-IR significantly improved compared to baseline, with FI, ISI₀, HOMA-β and HOMA-IR further ameliorating compared to the 12-month evaluation. Compared to non-HG patients, the HG patients still had a higher weight, BMI and WC. Conclusions: In hyperprolactinemic hypogonal men, proper testosterone replacement induces a significant improvement in the metabolic profile, even though the amelioration in the lipid profile might reflect the direct action of CAB.

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The differences between aromatizable and non-aromatizable androgens in relation to body composition and metabolic syndrome risk factors in men

Cited by 10 publications

References 39 publications

Human body morphology, prevalence of nasopharyngeal potential bacterial pathogens, and immunocompetence handicap principal

Human body morphology, prevalence of nasopharyngeal potential bacterial pathogens, and immunocompetence handicap principal

Serum Level of Zinc and Copper in Sudanese Women with Polycystic Ovarian Syndrome

Effect of Chronic Cabergoline Treatment and Testosterone Replacement on Metabolism in Male Patients with Prolactinomas

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