Serum Level of Zinc and Copper in Sudanese Women with Polycystic Ovarian Syndrome

Sharif, Manal E.; Adam, Isahg; Ahmed, Mohamed A.; Rayis, Duria A.; Hamdan, Hamdan Z.

doi:10.1007/s12011-017-1000-8

Cited by 21 publications

(28 citation statements)

References 32 publications

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“…It has been reported that Mg is central in the cell cycle, and that its deficiency is an important conditioner in precancerous cell transformation. On the other hand, at increased levels, magnesium can cause damage to the brain, liver, kidneys, and the developing foetus 31 In the current study, there were a significantly (P < 0.01) increased in level of Cu and significantly (P < 0.01) decreased in level of Zn in obese and non obese PCOS patients with primary and secondary, with compared to control. On the other hand, there was no significant change (P>0.05) when comparing the level of Cu and Zn between primary and secondary (in both obese and nonobese PCOS patients).…”

Section: Discussionsupporting

confidence: 39%

Study of Trace Elements Selenium, Copper, Zinc and Manganese Level in Polycystic Ovary Syndrome (PCOS)

Mohmmed¹,

Awad²,

Al–Fartosy³

2019

IJRASB

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Polycystic ovary syndrome (PCOS) is a common endocrine disorder in premenopausal women, trace elements play an important role in PCOS, selenium performs various biological functions such as defense against oxidative stress, immune function and thyroid function, polycystic ovary syndrome (PCOS) is a common endocrine disorder in premenopausal women, trace Elements have important role in PCOS, selenium is involved in many biological functions, such as, protection against oxidative stress, immune function and thyroid function, Copper, zinc and manganese are essential micronutrients that have been integrated into various proteins and metalloenzymes and are active in the metabolic process of cells and in oxidative stress pathways that can lead to oxidative stress. One hundred and twenty-four of patients' women with poly cystic ovarian syndrome (PCOS) patients and 56 normal ovulatory women participated in the study. Seleniumand serum Copper, zinc and manganese were measured by using flame atomic absorption spectrometry (FAAS).

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Section: Discussionsupporting

confidence: 39%

Study of Trace Elements Selenium, Copper, Zinc and Manganese Level in Polycystic Ovary Syndrome (PCOS)

Mohmmed¹,

Awad²,

Al–Fartosy³

2019

IJRASB

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“…The study also revealed that there is no significant difference in serum copper concentration between healthy and PCOS women. Although there were three previous studies that showed higher copper levels in PCOS group than healthy group 18 -20 , a recent study 22 showed no significant difference in copper levels as well between the two groups.…”

Section: Discussionmentioning

confidence: 81%

Untitled

2018

IJPSR

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Background:Multiple logistic regression analysis of several metabolic variables between polycystic ovary syndrome and control groups revealed that zinc level was the most important variable to predict polycystic ovarian syndrome. Objective: This study was designed to illustrate the correlation between zinc and copper levels with the biochemical changes associated with polycystic ovary syndrome. Materials and Methods: Twelve women with polycystic ovary syndrome and twelve healthy and normal ovulatory women were included in this study. The serum levels of luteinizing hormone, follicle stimulating hormone, progesterone, testosterone and prolactin were analyzed by enzyme linked immunosorbent assay. Serum zinc and copper was analyzed using atomic absorption spectrophotometer. Student (t) test was performed for comparison and Pearson's correlation coefficients (r) were calculated to quantify the correlation between the biochemical parameters in the study. Results: Both zinc and copper levels showed no significant correlation with other biochemical markers associated with polycystic ovary syndrome. The results revealed an increase in serum zinc concentration in polycystic syndrome group, while it showed no significant difference in copper levels between polycystic ovary syndrome and healthy groups. Conclusion: The study concluded that the rise in zinc level in polycystic ovary syndrome group might be due to the increase in oxidative stress within the body that put the antioxidant defense system in a hyperactive state in order to compensate for this stress.

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“…Zinc is considered as one of the cofactors of antioxidant enzymes, such as catalase (CAT) and SOD1 [72]. While the studies described in this review did not show any changes in SOD1 activity, changes in serum zinc concentration, serum copper concentration, as well as Cu/Zn ratio were observed in woman with PCOS [29,47,51]. Higher generation of ROS is postulated as one of the factors involved in the etiopathogenesis of PCOS [73], because it results in lipid peroxidation and damage of cell membrane lipids [48].…”

Section: Zinc and Polycystic Ovary Syndrome (Pcos)mentioning

confidence: 78%

The Role of Zinc in Selected Female Reproductive System Disorders

et al. 2020

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Zinc is an essential microelement that plays many important functions in the body. It is crucial for the regulation of cell growth, hormone release, immunological response and reproduction. This review focuses on its importance in the reproductive system of women of reproductive and postmenopausal ages, not including its well described role in pregnancy. Only recently, attention has been drawn to the potential role of zinc in polycystic ovary syndrome (PCOS), dysmenorrhea, or endometriosis. This review is mainly based on 36 randomized, controlled studies on reproductive, pre- and post-menopausal populations of women and on research trying to explain the potential impact of zinc and its supplementation in the etiology of selected female reproductive system disorders. In women with PCOS, zinc supplementation has a positive effect on many parameters, especially those related to insulin resistance and lipid balance. In primary dysmenorrhea, zinc supplementation before and during each menstrual cycle seems to be an important factor reducing the intensity of menstrual pain. On the other hand, little is known of the role of zinc in endometriosis and in postmenopausal women. Therefore, further studies explaining the potential impact of zinc and its supplementation on female reproductive system would be highly advisable and valuable.

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Serum Level of Zinc and Copper in Sudanese Women with Polycystic Ovarian Syndrome

Cited by 21 publications

References 32 publications

Study of Trace Elements Selenium, Copper, Zinc and Manganese Level in Polycystic Ovary Syndrome (PCOS)

Study of Trace Elements Selenium, Copper, Zinc and Manganese Level in Polycystic Ovary Syndrome (PCOS)

Untitled

The Role of Zinc in Selected Female Reproductive System Disorders

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