The Difference of Gut Microbiota and Their Correlations With Urinary Organic Acids Between Autistic Children With and Without Atopic Dermatitis

Hong, Ruping; Hou, Yue-ying; Xu, Xinjie; Lang, Ji-dong; Jin, Yajie; Zeng, Xiao-Feng; Zhang, Xuan; Tian, Geng; You, Xin

doi:10.3389/fcimb.2022.886196

Cited by 4 publications

(3 citation statements)

References 103 publications

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“…Furthermore, another study in a Chinese cohort found similar results to ours; F. plautii increased as the CKD severity increased [ 6 , 12 , 21 ]. Finally, enriched A. caccae levels have been observed in chronic inflammatory atopic dermatitis [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Perturbed gut microbiome and fecal and serum metabolomes are associated with chronic kidney disease severity

et al. 2023

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Background Chronic kidney disease (CKD) is a severe public health problem associated with a disordered gut microbiome. However, the functional alterations of microbiota and their cross talk with metabolism pathways based on disease severity remain unclear. Results We performed metagenomics and untargeted metabolomics in a cohort of 68 patients with CKD of differing severities and 20 healthy controls to characterize the complex interplay between the gut microbiome and fecal and serum metabolites during CKD progression. We identified 26 microbial species that significantly changed in patients with CKD; 18 species changed as the disease progressed, and eight species changed only in a specific CKD group. These distinct changes in gut microbiota were accompanied by functional alterations in arginine and proline, arachidonic acid, and glutathione metabolism and ubiquinone and other terpenoid-quinone biosynthesis pathways during CKD progression. Further metabolomic analyses revealed that the distributions of toxic and pro-oxidant metabolites from these four essential metabolic pathways varied in the feces and serum as CKD progressed. Furthermore, we observed a complex co-occurrence between CKD severity-related bacteria and the characterized metabolites from the four essential metabolic pathways. Notably, Ruminococcus bromii, fecal hydroquinone, and serum creatinine were identified as the main contributors to the integrated network, indicating their key roles in CKD progression. Moreover, a noninvasive model including R. bromii and fecal hydroquinone, L-cystine, and 12-keto-tetrahydro-LTB4 levels classified the CKD severity (area under the curve [AUC]: > 0.9) and had better performance than the serum creatinine level for mild CKD (AUC: 0.972 vs. 0.896). Conclusions Perturbed CKD severity-related gut microbiota may contribute to unbalanced toxic and pro-oxidant metabolism in the gut and host, accelerating CKD progression, which may be an early diagnostic and therapeutic target for CKD.

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Section: Discussionmentioning

confidence: 99%

Perturbed gut microbiome and fecal and serum metabolomes are associated with chronic kidney disease severity

et al. 2023

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“…Previous subtyping strategies are mostly defined by some particular symptom characteristics, such as social behavior or language ability ( 6 , 7 , 9 , 10 ). Another feasible approach is using biomedical features to stratify samples to reduce heterogeneity and produce subgroups which are more likely to share a more similar phenotype and etiology ( 11 , 12 , 59 ). Compared to the behavioral symptom characteristics, using biomedical features as subtyping indicators has some advantages, because they are more objective and easily to measure, more directly to indicate the possible mechanisms underlying the associated heterogeneity, and could also provide useful information to further explore the potential targets to facilitate the development of individualized biomedical therapy strategies for certain ASD subtypes.…”

Section: Discussionmentioning

confidence: 99%

Differences of gut microbiota and behavioral symptoms between two subgroups of autistic children based on γδT cells-derived IFN-γ Levels: A preliminary study

Lang²,

Yang

et al. 2023

Front. Immunol.

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BackgroundAutism Spectrum Disorders (ASD) are defined as a group of pervasive neurodevelopmental disorders, and the heterogeneity in the symptomology and etiology of ASD has long been recognized. Altered immune function and gut microbiota have been found in ASD populations. Immune dysfunction has been hypothesized to involve in the pathophysiology of a subtype of ASD.MethodsA cohort of 105 ASD children were recruited and grouped based on IFN-γ levels derived from ex vivo stimulated γδT cells. Fecal samples were collected and analyzed with a metagenomic approach. Comparison of autistic symptoms and gut microbiota composition was made between subgroups. Enriched KEGG orthologues markers and pathogen-host interactions based on metagenome were also analyzed to reveal the differences in functional features.ResultsThe autistic behavioral symptoms were more severe for children in the IFN-γ-high group, especially in the body and object use, social and self-help, and expressive language performance domains. LEfSe analysis of gut microbiota revealed an overrepresentation of Selenomonadales, Negatiyicutes, Veillonellaceae and Verrucomicrobiaceae and underrepresentation of Bacteroides xylanisolvens and Bifidobacterium longum in children with higher IFN-γ level. Decreased metabolism function of carbohydrate, amino acid and lipid in gut microbiota were found in the IFN-γ-high group. Additional functional profiles analyses revealed significant differences in the abundances of genes encoding carbohydrate-active enzymes between the two groups. And enriched phenotypes related to infection and gastroenteritis and underrepresentation of one gut–brain module associated with histamine degradation were also found in the IFN-γ-High group. Results of multivariate analyses revealed relatively good separation between the two groups.ConclusionsLevels of IFN-γ derived from γδT cell could serve as one of the potential candidate biomarkers to subtype ASD individuals to reduce the heterogeneity associated with ASD and produce subgroups which are more likely to share a more similar phenotype and etiology. A better understanding of the associations among immune function, gut microbiota composition and metabolism abnormalities in ASD would facilitate the development of individualized biomedical treatment for this complex neurodevelopmental disorder.

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“…The alpha diversity of the gut microflora was lower in the AD group. AD patients showed a higher abundance of Anaerostipes caccae, Eubacterium Hallii, and Bifidobacterium bifidum compared to controls, while the control group had a higher abundance of Akkermansia muciniphila, Roseburia intestinalis, Haemophilus parainfluenzae, and Rothia mucilaginosa [74].…”

Section: Atopic Dermatitismentioning

confidence: 91%

The Role of the Gut Microbiome and Microbial Dysbiosis in Common Skin Diseases

Ryguła,

Pikiewicz,

Grabarek

et al. 2024

IJMS

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Dermatoses are an increasingly common problem, particularly in developed countries. The causes of this phenomenon include genetic factors and environmental elements. More and more scientific reports suggest that the gut microbiome, more specifically its dysbiosis, also plays an important role in the induction and progression of diseases, including dermatological diseases. The gut microbiome is recognised as the largest endocrine organ, and has a key function in maintaining human homeostasis. In this review, the authors will take a close look at the link between the gut–skin axis and the pathogenesis of dermatoses such as atopic dermatitis, psoriasis, alopecia areata, and acne. The authors will also focus on the role of probiotics in remodelling the microbiome and the alleviation of dermatoses.

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The Difference of Gut Microbiota and Their Correlations With Urinary Organic Acids Between Autistic Children With and Without Atopic Dermatitis

Cited by 4 publications

References 103 publications

Perturbed gut microbiome and fecal and serum metabolomes are associated with chronic kidney disease severity

Perturbed gut microbiome and fecal and serum metabolomes are associated with chronic kidney disease severity

Differences of gut microbiota and behavioral symptoms between two subgroups of autistic children based on γδT cells-derived IFN-γ Levels: A preliminary study

The Role of the Gut Microbiome and Microbial Dysbiosis in Common Skin Diseases

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