'The difference in determinants of Chlamydia trachomatis and Mycoplasma genitalium in a sample of young Australian women.'

Walker, Jennifer; Fairley, Christopher K.; Bradshaw, Catriona; Tabrizi, Sepehr N.; Chen, Marcus Y; Twin, Jimmy; Taylor, Nicole; Donovan, Basil; Kaldor, John; McNamee, Kathleen; Urban, Eve; Walker, Sandra; Currie, Marian J.; Birden, Hudson; Bowden, Francis J.; Gunn, Jane; Pirotta, Marie; Gurrin, Lyle C.; Harindra, V; Garland, Suzanne M.; Hocking, Jane S

doi:10.1186/1471-2334-11-35

Cited by 77 publications

(66 citation statements)

References 40 publications

(61 reference statements)

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“…Individual PPVs for significant pathogens were low and NPVs were high, reflecting the low population STI prevalence, in keeping with other prevalence reports in similar populations 23. These values would increase with higher STI prevalence and more highly triaged situations, but might be lower in community settings.…”

Section: Discussionsupporting

confidence: 87%

Cervicitis aetiology and case definition: a study in Australian women attending sexually transmitted infection clinics

et al. 2015

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Section: Discussionsupporting

confidence: 87%

Cervicitis aetiology and case definition: a study in Australian women attending sexually transmitted infection clinics

et al. 2015

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“…As a positive control and for calculation of percent cytotoxicity, an equal number of cells were detergent lysed to determine the maximum releasable LDH. of it is standardized in any relevant way to host cells in vivo (3,5,32). Moreover, previous studies did not attempt to assess the relationship of organism burden to the host inflammatory response.…”

Section: Figmentioning

confidence: 99%

Persistent Mycoplasma genitalium Infection of Human Endocervical Epithelial Cells Elicits Chronic Inflammatory Cytokine Secretion

et al. 2012

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genitalium has yet to be defined, significant associations exist between M. genitalium and cervicitis, pelvic inflammatory disease (PID), and tubal infertility (23,25,30). Among female reproductive tract tissues, M. genitalium DNA has been detected in specimens from the vagina, endocervix, endometrium, and the fallopian tubes, suggesting that, after sexual transmission, the organism can disseminate from the lower to the upper tract. Similarly, outbred mice inoculated vaginally showed time-dependent ascension of M. genitalium from the vagina to the cervix, followed by detection in the uterus, fallopian tubes, and ovaries (27). Therefore, the cervix appears to be either a primary or transient target of infection. Considering the clinical associations of M. genitalium with urogenital inflammation, it remains imperative to investigate the basic mechanisms of mucosal infection and disease induced by this organism.Among male and female reproductive tract syndromes for which M. genitalium has been implicated, all could be attributed to long-term colonization of the urogenital tract, which we refer to here as "persistence." Consistent with the ability to survive longterm in urogenital tissues and similar to other sexually acquired urogenital pathogens, it is hypothesized that M. genitalium has evolved specific mechanisms to evade the host immune system. Indeed, persistent cervical infection has been observed in several clinical studies (4,6,10,13) and has been associated with chronic symptoms (4). Persistent infection by M. genitalium is likely mediated, at least in part, by recombinational variation of genes encoding surface-exposed antigens (13,14,22) and through intracellular localization (2,7,17,26,31). Despite these mechanisms for avoiding the host's immune system, M. genitalium appears to induce a significant inflammatory response, as demonstrated with epidemiologic associations with urogenital disease (25, 30) and the observation that human ecto-and endocervical epithelial cells respond to acute infection with proinflammatory cytokine secretion (26). A link to human immunodeficiency virus (HIV) infection has been observed (29) since cervicitis caused by M. genitalium occurs more often in HIV-positive subjects (20) and, importantly, since M. genitalium persists longer in these women (6). In addition, high M. genitalium burden is correlated with increased HIV shedding from the cervix (24). Collectively, under-

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“…M. genitalium er vanskeligere å påvise enn C. trachomatis, da bakteriemengden ofte er lav. Ekstraksjonsmetoden for bakterie-DNA er derfor en kritisk faktor (24,25). Viktigheten av metodevalg demonstreres i en studie der man sammenlignet tre ulike metoder for ekstraksjon av C. trachomatis-DNA og andelen positive funn varierte fra 4,3 % til 7,7 % (26).…”

Section: Diskusjonunclassified

“…Det er ikke funnet noen sammenheng mellom bakteriemengde og sykdom. Det viser seg at få bakterier også kan forårsake sykdom, og deteksjon av svake positive prøver er derfor av betydning (24). Vektlegging av denne problemstillingen har medført metodeforbedringer ved vårt laboratorium.…”

Section: Diskusjonunclassified

Prevalence of M. genitalium and U. urealyticum in urine tested for C. trachomatis

Paulsen¹,

Dahl²,

Skaare³

et al. 2016

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121Originalartikkel Forekomst av M. genitalium og U. urealyticum i urin testet for C. trachomatis 121 -5 Liv RESULTATER Forekomsten av C. trachomatis, M. genitalium og U. urealyticum var henholdsvis 11,9 %, 3,6 % og 17,9 %. M. genitalium forekom hyppigst hos kvinner i alderen 20 -24 år (5,1 %), mens det var størst andel positive prøver med U. urealyticum hos personer i alderen 15 -24 år (22,8 %).

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'The difference in determinants of Chlamydia trachomatis and Mycoplasma genitalium in a sample of young Australian women.'

Abstract: Background: Differences in the determinants of Chlamydia trachomatis ('chlamydia') and Mycoplasma genitalium (MG) genital infection in women are not well understood.

Cited by 77 publications

References 40 publications

Cervicitis aetiology and case definition: a study in Australian women attending sexually transmitted infection clinics

Cervicitis aetiology and case definition: a study in Australian women attending sexually transmitted infection clinics

Persistent Mycoplasma genitalium Infection of Human Endocervical Epithelial Cells Elicits Chronic Inflammatory Cytokine Secretion

Prevalence of M. genitalium and U. urealyticum in urine tested for C. trachomatis

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