Prevalence of M. genitalium and U. urealyticum in urine tested for C. trachomatis

Paulsen, Liv Kjersti; Dahl, Mette; Skaare, Dagfinn; Grude, Nils

doi:10.4045/tidsskr.14.1574

Cited by 5 publications

(4 citation statements)

References 29 publications

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“…Depending on the causative pathogen, STIs show unspecific symptoms, such as dysuria, urethral or vaginal discharge, pelvic pain and acyclic bleeding, but have serious reproductive health consequences beyond the immediate impact of the infection itself [3]. Symptoms of Mycoplasma and Ureaplasma infection are mild, but a chronic colonization leads to latent disturbed natural microbial flora and might increase the risk of acquisition of other pathogens [4]. Further they are associated with pelvic inflammatory disease (PID), which might lead to infertility [5,6], and intra amnionic and postpartum infections.…”

Section: Introductionmentioning

confidence: 99%

Prospective evaluation study on the benefit of the simultaneous detection of seven sexually transmitted pathogens for the clinical management of patients suffering from sexually transmitted diseases

Wendt

Tittelbach

Grimm

et al. 2019

Journal of Laboratory Medicine

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Abstract Background Sexually transmitted infections (STIs) represent a growing relevant public health problem. Early and accurate STI diagnosis is capable of preventing the spread and severe complications of curable STIs through pathogen adapted antibiotic treatment regimens. Limitations of current STI diagnostic tools are the lack of simultaneous pathogen detection and result quantification. Methods A prospective analysis of clinical specimens (n=100, from 82 symptomatic patients) from different sites of infections was performed. All samples were processed with multiplex real-time polymerase chain reaction (PCR) assay Anyplex™ II STI-7, using thermal cycler CFX96™. The Anyplex™ II STI-7 detection assay covers Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), Mycoplasma genitalium (MG), Mycoplasma hominis (MH), Ureaplasma parvum (UP), Ureaplasma urealyticum (UU) and Trichomonas vaginalis (TV). STI-7 results were compared to standard methods and transferred to the attending physician for treatment adjustment. Results Compared to performed standard method results the assay achieved sensitivities ranging from 90.9% to 100%, respectively, and specificities of 100%, with negative predictive values (NPV) ranging from 98.5% to 100%, respectively, and positive predictive values (PPV) of 100%. The Anyplex™ II STI-7 detection assay measured a Cohen’s kappa of 1.00 for UU/UP, MH, and MG and a Cohen’s κ agreement of 0.95 and 0.96 for NG and CT, respectively. Conclusions The Anyplex™ II STI-7 assay can easily be introduced into the microbiological laboratory work flow due to its short hands-on-time and PCR mutiplexity. The simultaneous detection of seven STI pathogens provides a comprehensive profile for each patient, enabling clinicians to decide on best treatment options, decreasing antibiotic misuse and infection spreading risk. The semi-quantitative results enables clinicians to gain a complete package of diagnostic information including disease diagnosis, disease degree severity and treatment monitoring, although. Further clinical studies on this topic are needed.

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Section: Introductionmentioning

confidence: 99%

Prospective evaluation study on the benefit of the simultaneous detection of seven sexually transmitted pathogens for the clinical management of patients suffering from sexually transmitted diseases

Wendt

Tittelbach

Grimm

et al. 2019

Journal of Laboratory Medicine

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“…[5] Present study also revealed that 4.8% of women with C. trachomatis and 11% of women with M. hominis also had M. genitalium infection, which is lower when compared to 9% of C. trachomatis - M. genitalium co-infected women that underwent population-based screening in London[8] and 11% in a screening study conducted in Norway. [9]…”

Section: Discussionmentioning

confidence: 99%

Assessing the need for routine screening for Mycoplasma genitalium in the low-risk female population: A prevalence and co-infection study on women from Croatia

Ljubin‐Sternak

Meštrović²,

Kolarić

et al. 2017

Int J Prev Med

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Background:There is an ongoing debate regarding possible cost and benefits, but also harm of universal screening for the emerging sexually transmitted pathogen Mycoplasma genitalium.Methods:From the initial pool of 8665 samples that were tested, a subset of Chlamydia trachomatis-positive and randomly selected C. trachomatis-negative cervical swabs were further interrogated for M. genitalium by real-time polymerase chain reaction, using a 224 bp long fragment of the glyceraldehyde-3-phosphate dehydrogenase gene.Results:M. genitalium was detected in 4.8% of C. trachomatis-positive samples and none of C. trachomatis-negative samples. Accordingly, a significant association was shown between M. genitalium and C. trachomatis (P < 0.01), but also between M. genitalium and Mycoplasma hominis infection (P < 0.01).Conclusions:Based on the results, routine screening is recommended only for women with one or more identified risk factors. Moreover, younger age does not represent an appropriate inclusion/exclusion criterion for M. genitalium testing in the low-risk female population.

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“…La oss starte med et eksempel. Paulsen og medarbeidere beskrev forekomsten av positive funn for tre forskjellige infeksjoner i urinprøver (1)…”

Section: Inntil Tre Hendelserunclassified

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Lydersen¹,

Skogvoll²

2023

Tidsskriftet

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Stian Lydersen er dr.ing. og professor i medisinsk statistikk ved Institu for psykisk helse ved NTNU. Forfa eren har fylt ut ICMJE-skjemaet og oppgir ingen interessekonflikter. Eirik Skogvoll er overlege og professor i anestesi ved St. Olavs hospital og NTNU. Forfa eren har fylt ut ICMJE-skjemaet og oppgir ingen interessekonflikter. Et venndiagram er ny ig for å illustrere forekomst av hendelser som kan inntreffe samtidig. Hvis vi skal beskrive forekomst av hendelser som ikke kan inntreffe samtidig, kan en enkel tabell eller et stolpediagram vaere egnet. Men ved hendelser som ikke utelukker hverandre, f.eks. visse symptomer eller diagnoser, er et venndiagram mer egnet.

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Prevalence of M. genitalium and U. urealyticum in urine tested for C. trachomatis

Cited by 5 publications

References 29 publications

Prospective evaluation study on the benefit of the simultaneous detection of seven sexually transmitted pathogens for the clinical management of patients suffering from sexually transmitted diseases

Prospective evaluation study on the benefit of the simultaneous detection of seven sexually transmitted pathogens for the clinical management of patients suffering from sexually transmitted diseases

Assessing the need for routine screening for Mycoplasma genitalium in the low-risk female population: A prevalence and co-infection study on women from Croatia

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