The difference in C-reactive protein value between initial and 24 hours follow-up (D-CRP) data as a predictor of mortality in organophosphate poisoned patients

Lee, Jun Ho; Lee, Young Hwan; Park, Yong Hwan; Kim, Yong Hwan; Hong, Chong Kun; Cho, Kwang Won; Hwang, Seong Youn

doi:10.3109/15563650.2012.745939

Cited by 30 publications

(25 citation statements)

References 12 publications

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“…This was similar to the results observed by Lee et al (2008) and Yu et al (2012) who mentioned that there were significant differences in heart rate, systolic blood pressure, respiratory rate and body temperature between survivors and non-survivors. Also, this was in agreement with Lee et al (2013) study in which there was significant association between the mortality and decrease in respiratory rate. Severe and refractory hypotension is a leading cause of death in OP poisoning.…”

Section: Discussionsupporting

confidence: 93%

“…Bradycardia is recorded more frequently in patients with delayed presentation to the hospital and this finding is strongly associated with mortality (Gündüz et al, 2015). In Lee et al (2013) study there was significant association between the mortality and decrease in respiratory rate which reflect that the respiratory insufficiency is important leading cause of death in OP poisoning. Similarly, Davies et al (2008) reported that GCS was effective at predicting outcome in acute organophosphate poisoning and patients presenting with a GCS ≤ 13 need intensive monitoring and treatment.…”

Section: Discussionmentioning

confidence: 81%

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Predictive Value of Triage Vital Signs and Conscious Level for Outcome Evaluation in Acutely Organophosphate Poisoned Patients

Moussa

Mohamed

Hilal

et al. 2018

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

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Triage in Emergency departments requires emergency doctors to make rapid decisions based on their knowledge and experiences. Triage of patients is critical to patient safety, yet no clear information exists by the utility of initial vital signs and conscious level in identifying critically ill acutely organophosphate (OP) poisoned patients. The objective of this study is to determine the relationship between triage vital signs and conscious level in predicting outcome of acutely organophosphate poisoned patients. A retrospective and prospective study was carried out on 200 patients of acute OP poisoning admitted to the Poison Control Center (PCC), Ain Shams University Hospitals. Information including vital signs and Glasgow coma scale (GCS) on admission after obtaining the permission of the director of PCC and the regional ethics committee was collected from the sheets and computerized data base of the patients, an informed written consent has been obtained from each patient or from his/her caregiver for inclusion in the prospective part of the study. The results were revised, coded and organized for statistical analysis. The study results revealed 180 (90%) patients discharged and 20 (10%) patients died. The study also showed that 8% of patients had fever, 9.5% had tachycardia, 1.5% had bradycardia, 5% had hypotension, 2% had hypertension, 2.5% had tachypnea and 3.5% showed bradypnea. Also 89% of patients had GCS > 8, while 11% of patients had GCS ≤ 8. The study showed statistically significant difference between discharged and died patients as regards heart rate, blood pressure, respiratory rate, body temperature and GCS. It could be concluded that heart rate, respiratory rate and coma scale can serve as easily measurable tools for outcome prediction in acutely OP poisoned patients. From the previous results, our study recommends to use these parameters to help emergency physicians to quickly detect poisoned patients with poor outcomes.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 81%

Predictive Value of Triage Vital Signs and Conscious Level for Outcome Evaluation in Acutely Organophosphate Poisoned Patients

Moussa

Mohamed

Hilal

et al. 2018

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

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“…A study of OP poisoning patients in the ICU performed by Lee et al found that the mean SOFA score of survivors was 3.9 ± 2.9 and 6.7 ± 2.7 for nonsurvivors. [21] The patients who died in our study had a median SOFA score of 5 while the score of those who survived had a median score of 1.…”

Section: Discussionmentioning

confidence: 64%

A retrospective review of intensive care management of organophosphate insecticide poisoning: Single center experience

et al. 2015

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Background: Organophosphate (OP) compounds are used as insecticides. Given the widespread availability and use of these chemicals, OP poisoning is quite common following either accidental or intentional exposures. Immediate intensive care management can save lives in these patients. We aimed to investigate intensive care management provided to OP poisoning patients in a tertiary care hospital in Turkey. Subjects and Methods: This was a retrospective chart review of 62 patients, admitted to the Intensive Care Unit (ICU) with OP poisoning between 2000 and 2012. Results: Of the 62 patients studied, 40 (65%) were male, 45 (73%) were suicide attempts, 59 (95%) ingested the OP compounds, and three patients (5%) (two patients with suicide and 1 with accidental exposure) died in the ICU. There were statistically significant differences between survivors and nonsurvivors for Glasgow Coma Scale (GCS) on admission (P = 0.034), Acute Physiology and Chronic Health Evaluation II (APACHE II) score (P = 0.003), Sequential Organ Failure Assessment (SOFA) score (P = 0.024), time to initiation of treatment (P = 0.034) and serum lactate dehydrogenase (LDH) levels (P = 0.007). Conclusions: Organophosphate poisoning is a life-threatening condition that requires immediate diagnosis and management. GCS, APACHE II score, SOFA score, and time to admission to the emergency department and LDH levels can provide prognostic information and predict outcomes.

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“…Mortality rate in the present study was 33.3%. Lee et al, (2013) reported that mortality was 22.9%. However, a 12% death rate was recorded by Sun et al, (2015), he reflected this low mortality to proper atropine administration and close monitoring of intoxicated patients in intensive care unit.…”

Section: Discussionmentioning

confidence: 99%

Prediction of Acute Organophosphate Poisoning Using Glasgow Coma Sale, Serum Cholinesterase and S100B

Oreby

Elmadah

2017

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

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All rights reserved. Introduction rganophosphates are the most widely used pesticides for killing agricultural pests all over the world as a result of its availability, low coast, and rapid degradation. Despite all efforts to improve management of them, accidental and suicidal ingestion is still a major public health problem. They are life-threatening condition associated with high morbidity and mortality especially in developing countries (Coskun et al., 2015). Organophosphates compounds deposit a phosphoryl group at acetylcholinesterase enzyme resulting in its inhibition at the muscarinic and nicotinic synapses. The net effect is accumulation of acetylcholine and uncontrolled activation of cholinergic synapses (Costa, 2006; Jokanović, 2009). Furthermore, glia and neurons apoptotic death may be another mechanism of OP poisoning (Bozkurt et al., 2010). Glia are the most common cells in the brain, providing critical nutritional, structural, and homeostatic support that is essential to the architectural modeling of the brain and to the establishment and maintenance of synaptic function (Garcia et al., 2001). Astroglial cells are known to be as sensitive as neurons to hypoxic stress. Therefore, a marker for astroglial cell damage may indirectly reflect neuronal damage (Bottiger et al., 2001). The protein S100 is a calcium-binding protein that has various effects on glia and neurons. There are 19 S-100 proteins, 4 subtypes present in human tissue: S-100A1 (striated muscles, heart, and kidneys), S-100A1B (astroglial cells), S-100B (astroglial and

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The difference in C-reactive protein value between initial and 24 hours follow-up (D-CRP) data as a predictor of mortality in organophosphate poisoned patients

Cited by 30 publications

References 12 publications

Predictive Value of Triage Vital Signs and Conscious Level for Outcome Evaluation in Acutely Organophosphate Poisoned Patients

Predictive Value of Triage Vital Signs and Conscious Level for Outcome Evaluation in Acutely Organophosphate Poisoned Patients

A retrospective review of intensive care management of organophosphate insecticide poisoning: Single center experience

Prediction of Acute Organophosphate Poisoning Using Glasgow Coma Sale, Serum Cholinesterase and S100B

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