Prediction of Acute Organophosphate Poisoning Using Glasgow Coma Sale, Serum Cholinesterase and S100B

Oreby, Merfat; Elmadah, Enas I.

doi:10.21608/ajfm.2017.18309

Cited by 3 publications

(1 citation statement)

References 30 publications

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“…Pseudocholinesterase was reduced in the moderate and severe group pseudocholinesterase level. These data suggested that S100B may be a useful marker in the assessment of clinical severity and prediction of mortality in acute OP (Oreby and El madah 2017). The Aβ protein is an acute phase protein; its elevation in serum is one of the most rapid and intense sensitive markers in neurodegenerative disease (Jenna et al 2019).…”

Section: Discussionmentioning

confidence: 99%

Detection the severity of organophosphate intoxication using sensitive serum biomarkers S100B and amyloid β (Aβ) in Egyptian subjects

Elhady,

Adly,

Elshebiny

et al. 2023

Environ Sci Pollut Res

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Organophosphate (OP) is a compound considered the main leading cause of morbidity and mortality from poisoning worldwide. Serum pseudocholinesterase was evaluated as a diagnostic indicator; it cannot be used to monitor therapy or severity of the intoxication. The rationale of the current study was to evaluate sensitivity, specificity, and cut-off values of serum S100B and amyloid β for neurological affection severity. This study was carried out on sixty OP-impaired patients; in addition, 20 normal controls were included. Serum liver and kidney function tests, malondialdehyde, pseudocholinesterase, and the levels of S100B and amyloid β (Aβ) were determined. Data showed that Pearson’s analysis indicated that the serum level of S100B was positively correlated with Aβ. On the contrary, the activity of pseudocholinesterase was negatively correlated with both of S100B and Aβ. Serum ALT, AST, creatinine, urea, acetylcholine, and MDA levels were elevated while pseudocholinesterase activity was reduced in moderate and severe OP intoxication versus control. A drastic elevation (p<0.001) in the levels of S100B and Aβ was performed in the patient group suffering from OP intoxication versus the normal group. The diagnostic statistical validation of targeted parameters in distinguishing between moderate OP intoxication and control clarifies that S100B displayed the best AUC (0.997) followed by Aβ (AUC=0.992), while the diagnostic veracity of S100B and Aβ in setting apart severe OP-intoxicated and normal subjects stated the symmetric efficacy of potential markers. It was concluded that the significant changes in the levels of S100B and Aβ were directly proportional to the degree of severity of OP intoxication.

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Section: Discussionmentioning

confidence: 99%

Detection the severity of organophosphate intoxication using sensitive serum biomarkers S100B and amyloid β (Aβ) in Egyptian subjects

Elhady,

Adly,

Elshebiny

et al. 2023

Environ Sci Pollut Res

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The reversed De Ritis ratio for predicting in-hospital mortality among intensive care patients with organophosphate poisoning

2022

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Assessment of the efficacy of four scoring systems in prediction of acute organophosphorous poisoning outcome

Shama

El-Gharbawy

Wahdan

et al. 2021

Tanta Medical Journal

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Background Organophosphorous (OP) compounds are one of the major classes of pesticides. In developing countries, acute OP poisoning is a significant health problem due to its high mortality rate. Aim This study aimed to compare the efficacy of four scoring systems: Acute Physiology and Chronic Health Evaluation II (APACHE II), Poison Severity Score (PSS), Rapid Emergency Medicine Score (REMS), and Sequential Organ Failure Assessment (SOFA) score for outcome prediction in acute OP-poisoned cases. Patients and methods This cohort study included 100 cases with acute OP poisoning admitted to Tanta University Poison Control Center from the August 1, 2019 to the end of July 2020. The sociodemographic data, clinical examination, and laboratory investigations were recorded. From the collected data, the four scores were calculated for every patient. Results The present study demonstrated that survivors were 92% and nonsurvivors were 8%. About 14% of patients needed intubation, mechanical ventilation, and ICU admission. Regarding prediction of mortality, nonsurvivors had significant higher values of the studied scores than survivors, except for PSS. Furthermore, receiver-operating characteristic curve analysis showed that REMS had the best area under the curve followed by APACHE II score and then SOFA score. Concerning prediction of the need of intubation, mechanical ventilation, and ICU admission, the study recorded statistically significant differences between the two groups regarding all studied scores and REMS had the best area under the curve followed by APACHE II score, SOFA score, and then PSS. Conclusion REMS was the best score for prediction of acute OP poisoning outcome.

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Prediction of Acute Organophosphate Poisoning Using Glasgow Coma Sale, Serum Cholinesterase and S100B

Cited by 3 publications

References 30 publications

Detection the severity of organophosphate intoxication using sensitive serum biomarkers S100B and amyloid β (Aβ) in Egyptian subjects

Detection the severity of organophosphate intoxication using sensitive serum biomarkers S100B and amyloid β (Aβ) in Egyptian subjects

The reversed De Ritis ratio for predicting in-hospital mortality among intensive care patients with organophosphate poisoning

Assessment of the efficacy of four scoring systems in prediction of acute organophosphorous poisoning outcome

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