The dielectric properties of the cerebellum, cerebrum and brain stem of mouse brain at radiowave and microwave frequencies

Nightingale, N R V; Goodridge, V D; Sheppard, R J; Christie, J L

doi:10.1088/0031-9155/28/8/002

Cited by 31 publications

(11 citation statements)

References 8 publications

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“…Calculated SAR values have been shown to correspond closely with measured SAR values [42]. SAR was calculated from the below equation, with σ (0.88 sec/m) and ρ (1030 kg/m 3 ) values attained from Nightingale et al [43]: …”

Section: Methodsmentioning

confidence: 97%

Electromagnetic Treatment to Old Alzheimer's Mice Reverses β-Amyloid Deposition, Modifies Cerebral Blood Flow, and Provides Selected Cognitive Benefit

et al. 2012

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Few studies have investigated physiologic and cognitive effects of “long-term" electromagnetic field (EMF) exposure in humans or animals. Our recent studies have provided initial insight into the long-term impact of adulthood EMF exposure (GSM, pulsed/modulated, 918 MHz, 0.25–1.05 W/kg) by showing 6+ months of daily EMF treatment protects against or reverses cognitive impairment in Alzheimer's transgenic (Tg) mice, while even having cognitive benefit to normal mice. Mechanistically, EMF-induced cognitive benefits involve suppression of brain β-amyloid (Aβ) aggregation/deposition in Tg mice and brain mitochondrial enhancement in both Tg and normal mice. The present study extends this work by showing that daily EMF treatment given to very old (21–27 month) Tg mice over a 2-month period reverses their very advanced brain Aβ aggregation/deposition. These very old Tg mice and their normal littermates together showed an increase in general memory function in the Y-maze task, although not in more complex tasks. Measurement of both body and brain temperature at intervals during the 2-month EMF treatment, as well as in a separate group of Tg mice during a 12-day treatment period, revealed no appreciable increases in brain temperature (and no/slight increases in body temperature) during EMF “ON" periods. Thus, the neuropathologic/cognitive benefits of EMF treatment occur without brain hyperthermia. Finally, regional cerebral blood flow in cerebral cortex was determined to be reduced in both Tg and normal mice after 2 months of EMF treatment, most probably through cerebrovascular constriction induced by freed/disaggregated Aβ (Tg mice) and slight body hyperthermia during “ON" periods. These results demonstrate that long-term EMF treatment can provide general cognitive benefit to very old Alzheimer's Tg mice and normal mice, as well as reversal of advanced Aβ neuropathology in Tg mice without brain heating. Results further underscore the potential for EMF treatment against AD.

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Section: Methodsmentioning

confidence: 97%

Electromagnetic Treatment to Old Alzheimer's Mice Reverses β-Amyloid Deposition, Modifies Cerebral Blood Flow, and Provides Selected Cognitive Benefit

et al. 2012

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“…The dielectric properties of the mouse brain were estimated according to the published parameters [17,18], σ = 0.8 S/m (average brain value) and mass density ρ = 1040 kg/m 3 .…”

Section: Emf Measurements -Dosimetrymentioning

confidence: 99%

Short-term memory in mice is affected by mobile phone radiation

et al. 2011

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“…The dielectric properties of biological tissues have been widely studied and reviewed, providing a huge database of dielectric properties of biological tissues of humans and different kinds of animals, including rats, pigs, mice, rabbits, bovines, dogs, and felines [Lin, 1975;Lin et al, 1975;Foster et al, 1979;Schepps and Foster, 1980;Foster and Schepps, 1981;Stuchly et al, 1981;Nightingale et al, 1983;Thurai et al, 1985;Surowiec et al, 1988;Joines et al, 1994;Foster and Schwan, 1995;Gabriel et al, 1996;Peyman et al, 2002Peyman et al, , 2007Schmid et al, 2003;Karacolak et al, 2009;Peyman and Gabriel, 2010]. In addition to its benefits for general knowledge, data about dielectric properties of biological tissues are important for examining and testing new microwave imaging systems [Abubakar et al, 2002;Zhang and Liu, 2004;Ireland and Abbosh, 2013;Mobashsher et al, 2014;Mohammed et al, 2014].…”

Section: Introductionmentioning

confidence: 99%

Dielectric properties of dog brain tissue measured in vitro across the 0.3–3 GHz band

Mohammed

Bialkowski

Abbosh

et al. 2016

Bioelectromagnetics

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Dielectric properties of dead Greyhound female dogs' brain tissues at different ages were measured at room temperature across the frequency range of 0.3-3 GHz. Measurements were made on excised tissues, in vitro in the laboratory, to carry out dielectric tests on sample tissues. Each dataset for a brain tissue was parametrized using the Cole-Cole expression, and the relevant Cole-Cole parameters for four tissue types are provided. A comparison was made with the database available in literature for other animals and human brain tissue. Results of two types of tissues (white matter and skull) showed systematic variation in dielectric properties as a function of animal age, whereas no significant change related to age was noticed for other tissues. Results provide critical information regarding dielectric properties of animal tissues for a realistic animal head model that can be used to verify the validity and reliability of a microwave head scanner for animals prior to testing on live animals. Bioelectromagnetics. 37:549-556, 2016. © 2016 Wiley Periodicals, Inc.

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The dielectric properties of the cerebellum, cerebrum and brain stem of mouse brain at radiowave and microwave frequencies

Cited by 31 publications

References 8 publications

Electromagnetic Treatment to Old Alzheimer's Mice Reverses β-Amyloid Deposition, Modifies Cerebral Blood Flow, and Provides Selected Cognitive Benefit

Electromagnetic Treatment to Old Alzheimer's Mice Reverses β-Amyloid Deposition, Modifies Cerebral Blood Flow, and Provides Selected Cognitive Benefit

Short-term memory in mice is affected by mobile phone radiation

Dielectric properties of dog brain tissue measured in vitro across the 0.3–3 GHz band

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