The Dialogue of Constitutional Judges

Safta, Marieta; Toader, Tudorel

doi:10.3726/978-3-653-07031-6

Cited by 9 publications

(24 citation statements)

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“…There must be stated that all the animals involved in the experiment were treated according to the existing guidelines of animal bioethics stated in the Act on Animal Experimentation and Animal Health and Welfare Act from Romania. All procedures applied were in conformity with the modern specific legislation [28][29][30][31][32][33][34]. Efforts were made to minimize animal suffering and to decrease the number of animals included.…”

Section: Experimental Part Materials and Methodsmentioning

confidence: 99%

The Effect of Exercising on Oxidative Stress Status and Pain in a Valproic-acid Induced Model of Autism Possible relevance of oxytocin

Antioch¹,

Ababei²,

Lefter³

et al. 2017

Rev. Chim.

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In this report we will describe the effect of exercising (6 days, each day 3 separate training phases of 5 minutes each, on an adapted treadmill at 1.0 m/s) on oxidative stress status from the temporal lobe (expressed through 3 main parameters: superoxide dismutase (SOD), glutathione peroxidase (GPX) and malondialdehyde (MDA), as a marker of lipid peroxidation) and pain (as determined through 2 specific behavioural tasks such as hot plate test for the supraspinal acute thermal pain and the intra abdominal Zymosan administration for eliciting a local inflammatory reaction following responses to inflammatory visceral pain) in a rat valproic-acid induced perinatal model of autism, also trying to emphasize a possible implication of oxytocin in this complex pathological picture. We demonstrated here an increased oxidative stress status, as a result of treadmill exercising, in a VPA rat induced model of autism, as demonstrated mainly by a significant decrease in the specific activity of SOD (for the exercised VPA female rats), as well as a significant decrease of GPX specific activity in the male VPA exercised rats, when compared to nonexercised VPA groups, as well as the fact that the aforementioned series of exercises did not resulted in any changes of the pain perception of this rat models of autism, as studied in 2 pain-related behavioural tasks, independent to the gender of the rats with VPA model of autism.

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Section: Experimental Part Materials and Methodsmentioning

confidence: 99%

The Effect of Exercising on Oxidative Stress Status and Pain in a Valproic-acid Induced Model of Autism Possible relevance of oxytocin

Antioch¹,

Ababei²,

Lefter³

et al. 2017

Rev. Chim.

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“…494 of 10 July 2002. According to Article 119 of the Fundamental Law, the central role in coordinating and organising activities in the field of national security lies with the SCND [2], defined as an autonomous administrative authority whose activity is verified by employing parliamentary control.…”

Section: Supreme Council Of National Defencementioning

confidence: 99%

The implications of cybercrime for national security

Apachiţei,

Ichim

2023

SHS Web Conf.

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This study aims to identify the general aspects concerning the elements of correspondence between the notion of cybercrime and the field of national security by analysing the regulatory and institutional framework. Electronic information concerning national security requires concrete measures for its identification and control, as its alteration, theft, or modification may constitute a source of vulnerability for the security of the State and its citizens. In this respect, the architecture of the regulatory framework we are considering concerns national security provisions and the protection of classified information.

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“…The experimental procedures were carried out in accordance with the mandatory principles of the ethics in clinical studies [15,16].…”

Section: Study Groupmentioning

confidence: 99%

Correlation Between the Tyrozinkinazine Inhibitor Sunitinib - Dose, Schedule of Administration and Adverse Events

Stănculeanu¹,

Zob²,

Toma³

et al. 2017

Rev. Chim.

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Sunitinib, a multi-targeted receptor tyrosine kinase inhibitor, has demonstrated survival benefit in patients with metastatic renal cell carcinoma (mRCC) and is generally well tolerated with most adverse events, manifesting as mild to moderate in severity. The most frequent related adverse events include hand-foot syndrome (HFS), hypertension, proteinuria, cardiac toxicities, myelosuppression, fatigue/asthenia, hypothyroidism, diarrhea and hepatotoxicity. The study aims to determine incidence of adverse events among patients with metastatic renal cell carcinoma (mRCC) treated Sunitinib within five years from 2010 to 2015 and comparing the results with data from literature. The study included a total of 56 patients treated with Sunitinib, with a dose of 50 mg (Schedule 4/2). Due to adverse events and individual safety and tolerability, at the indication of the personal clinician, 11 patients needed dose reduction, with a continuous dose of 37.5 mg, daily and 28 patients continued the dose of 50 mg taken daily, on a different schedule (2/ 1 schedule). The most important toxicities were anemia, leukopenia, thrombocytopenia, gastrointestinal effects (diarrhea), fatigue and hypertension. After dose reduction or modified schedule the incidence of the most frequent toxicities (HFS, leukopenia, thrombocytopenia and fatigue) decreased, but hypertension was still observed in 30% of patients. The results are similar with data from literature. Early identification of individuals at risk and monitoring patients during Sunitinib treatment is very important and it can facilitate early intervention with prophylactic measures or supportive treatment, thus increasing quality of life and adherence to treatment. Further studies need to establish which targeted population can benefit the most from adjusted regimens and to correlate them with prognostic factors for survival.

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The Dialogue of Constitutional Judges

Cited by 9 publications

References 0 publications

The Effect of Exercising on Oxidative Stress Status and Pain in a Valproic-acid Induced Model of Autism Possible relevance of oxytocin

The Effect of Exercising on Oxidative Stress Status and Pain in a Valproic-acid Induced Model of Autism Possible relevance of oxytocin

The implications of cybercrime for national security

Correlation Between the Tyrozinkinazine Inhibitor Sunitinib - Dose, Schedule of Administration and Adverse Events

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