The diagnostic value of Ki-67, P53 and P63 in distinguishing partial Hydatidiform mole from hydropic abortion

Abstract

The high Ki-67 labeling index and over-expression of p53, detected by immunohistochemistry, could serve as useful adjuncts to conventional methods of diagnosis in distinguishing PHM from HA. Due to, however, the limited samples, it needs to expand the number of the cases to verify this conclusion.

Disordered p53‐MALAT1 pathway is associated with recurrent miscarriage

“…To explore the roles of p53 during the pathogenesis of RM, we first detected the p53 protein level in the villous tissues from 27 RM patients and paired healthy controls. We observed overexpressed p53 in the RM patients, which is in accordance with results of other researchers (Figure A,B) . Recently, lncRNAs have been identified to function as key regulators of diverse cellular processes including pregnancy .…”

“…Figure 1A,B). [5][6][7][8] Recently, lncRNAs have been identified to function as key regulators of diverse cellular processes including pregnancy. 16 As a transcription factor, p53 has been found modulate the expression of many lncRNAs.…”

“…Several single nucleotides polymorphisms were found to contribute to the high risk of RM . Meanwhile, p53 has been observed to be expressed abnormally in the chorionic villi and decidua of females with hydropic, spontaneous or missed abortions, and high p53 level in the chorionic villi from patients with RM was also observed, indicating its important roles during the pathogenesis of RM …”

“…5 Meanwhile, p53 has been observed to be expressed abnormally in the chorionic villi and decidua of females with hydropic, spontaneous or missed abortions, and high p53 level in the chorionic villi from patients with RM was also observed, indicating its important roles during the pathogenesis of RM. [5][6][7][8] Depend on the recent discovery, nearly 75% of the human genome is transcribed to RNA, with only about 1.2% being responsible for protein coding, which indicates that a large group of RNA regulators is dedicated to regulating a relatively small amount of effectors. [9][10][11] Among the newly discovered RNA elements, long noncoding RNAs (lncRNAs) have been identified to function as key regulators of diverse cellular processes, such as development, differentiation, and cell fate as well as disease pathogenesis.…”

Immunoexpression of P53 protein in trophoblastic diseases

“…19 Other studies found the same with the conclusion that P53 can be used to differentiate between abortion and GTD and subtypes of molar pregnancy. 13,20,21 Yazaki et al, 2006 showed that there is statistically a significance difference between patients of HM, patient progress to GTN or spontaneous abortion regarding the p53 immunoexpression P <0.05. 7 Other studies had investigated other tumor suppressor protein such as P63 (which is a p53 homologue) and found -ve p63 expression in cytotrophoblasts, syncytiotrophoblasts in all cases of abortion and +ve expression in all cases of PHM and CHM.…”