The Diagnostic Value of Eeg and Biochemical Markers of Brain Injury in Hypoxic-Ischemic Encephalopathy

Blinov, V. A.

doi:10.17749/2077-8333.2016.8.4.091-098

Cited by 4 publications

(3 citation statements)

References 1 publication

(1 reference statement)

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“…Современными основными методами диагностики специфических морфологических нарушений при ГИЭ (Volpe J.J., 2001) являются: нейросонография (НСГ), компьютерная томография головного мозга (КТ), магнитно-резонансная томография головного мозга (МРТ) и электроэнцефалография (ЭЭГ), которые помогают идентифицировать и охарактеризовать точное местоположение, степень и тяжесть поражения головного мозга [1,2,6,15,16,17]. НСГ представляет собой недорогой и мобильный метод, обладающий минимальной радиационной нагрузкой.…”

Section: Introductionunclassified

“…Sarnat, M.S. Sarnat нередко ограничена применением седативных препаратов, субъективностью оценки, наличием сопутствующей патологии, невозможностью адекватно оценить ряд рефлексов (например, Моро и сосания) у новорождённых на искусственной вентиляции лёгких [15]. Гипоксические поражения головного мозга сопровождаются угнетением электрической активности коры, судорожной активностью.…”

Section: Introductionunclassified

“…Исходя из вышеописанного, в настоящее время ЭЭГ не может расцениваться в качестве изолированного метода, позволяющего судить о прогнозе и исходе заболевания. Для того, чтобы составить максимально точный прогноз, данные ЭЭГ должны применяться вместе с данными других клинических, инструментальных и лабораторных методов диагностики [1,15,16].…”

Section: Introductionunclassified

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Optimization of Hypoxic Brain Injuries Diagnostics in Full-Term Newborns

Panova

Панченко

Mudrov

2021

Acta biomedica scientifica

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The problem of early diagnosis of the central nervous system damage in newborn before the onset of clinical symptoms remains relevant at the present time.The aim of the study was to optimize the hypoxic brain damage diagnosis in full-term newborns by analyzing the concentration of cytokines in the umbilical cord blood.Materials and methods. During the first stage of the study, a prospective analysis of concentrations of interleukins (IL-1β, IL-4, IL-6, IL-8, IL-10), TNF-α and neuron-specific enolase (NSE) in the umbilical cord blood serum of full-term newborns was performed. The second stage of the study included the retrospective analysis of clinical data and instrumental research methods. The main method for diagnosing in the development of hypoxic brain damage in newborns was neurosonography.Results. The development of hypoxic brain damage is evidenced by the concentration of IL-1β over 30.3 pg/ml, IL-4 – over 1.7 pg/ml, IL-6 – over 79.4 pg/ml, IL-8 – over 107.7 pg/ml, NSE – more than 10.3 ng/ml and TNF-α – more than 1.6 pg/ml in umbilical cord blood.Conclusion. The results of the study confirmed that the comprehensive assessment of the cytokines concentration in the umbilical cord blood improves the hypoxic brain damage diagnosis in newborns. Analysis of the level of these markers immediately after the birth will optimize the management tactics of newborns who have undergone hypoxic exposure in antenatal and intranatal period.

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Section: Introductionunclassified

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Optimization of Hypoxic Brain Injuries Diagnostics in Full-Term Newborns

Panova

Панченко

Mudrov

2021

Acta biomedica scientifica

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Gestational diabetes mellitus and obesity: effects on offspring

Рожкова

Ремнева

Fadeeva

et al. 2021

Akušerstvo, ginekologiâ i reprodukciâ

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Aim: to identify the risk factors for gestational diabetes mellitus (GDМ) and predictors of perinatal lesions of central nervous system (CNS) combined with GDМ and maternal obesity.Materials and Methods. А retrospective observational case-control non-combined study was conducted to determine GDМ risk factors and their effect on perinatal pathology in 250 women divided into 2 groups. The main group included 150 pregnant women diagnosed with GDМ, the control group – 100 pregnant women without carbohydrate metabolism disorders. An assessment of hereditary, obstetric and gynecological history, as well as somatic health was carried out. Patients from the main group were subdivided into smaller groups: 1А (n = 77) – mothers whose newborns postnatally exerted adverse perinatal outcomes associated with impacting maternal hyperglycemia, and 1В (n = 73) – mothers whose newborns were born healthy. CHAID method (Chi Squared Automatic Interaction Detection) was used to create an algorithm for predicting adverse perinatal outcomes in GDМ. Аt the second stage, a single-center prospective observational non-combined cohort study was conducted to assess an effect of maternal hyperglycemia on formation of perinatal CNS lesions. Pre-labor concentration of neuron-specific enolase (NSE) was measured in the amniotic fluid of full-term fetuses in the group of pregnant women with GDM (n = 33) and in the group of pregnant women lacking carbohydrate metabolism disorders (n = 42).Results. Obesity, late reproductive age, family history of type 2 diabetes mellitus, abortions, early reproductive losses, macrosomic delivery in history are the main risk factors for GDM development. An algorithm was developed that allowed to predict a risk of newborn perinatal pathology in mother with GDM with an overall percentage of correct predictions of 68.7 ± 3.8 %. Pre-labor concentration of NSE in the amniotic fluid of full-term fetuses was elevated by 1.68 times (p = 0.006) in women with combined GDM and obesity (5.56 [3.37–6.24] ng/ml) compared to pregnant women with normal weight lacking carbohydrate metabolism disorders (3.29 [1.49–4.89] ng/ml).Conclusion. Pregnant women with obesity and type 2 diabetes mellitus familial history were featured with most prominent potential of developing perinatal complications. Rise in amniotic fluid NSE level in patients with GDМ corroborates damage of fetal CNS during antenatal period. The maximum NSE level was found in women comorbid with GDM and obesity.

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Markers of brain damage in full-term newborns with intrauterine growth retardation

Evsyukova

2021

Journal of obstetrics and women's diseases

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The increase in the number of newborns with intrauterine growth retardation, who are characterized not only by high perinatal morbidity and mortality, but also by neurodevelopmental disorders in later life, has determined a wide search for diagnostic markers of prenatal hypoxia for a timely objective assessment of brain damage and a justification of neuroprotection methods. This article presents literature data on biomarkers and methods of instrumental diagnosis of brain damage that have received evidence of the effectiveness of their use in early neonatal life of newborns with intrauterine growth retardation. It is emphasized that such biomarkers as S100B, NSE, and BDNF proteins are the most reliable and easy to determine non-invasively. However, for their wide application in clinical practice, it is necessary to establish reference values in umbilical cord blood and urine, while taking into account the gestational age, sex, and method of giving birth, and to unify the use of laboratory analysis systems and diagnostic tests for this purpose. The comparison of biomarker indicators with cerebral oximetry, electroencephalogram and magnetic resonance imaging data will allow for developing new approaches to the treatment of perinatal pathology and, largely, preventing adverse consequences in those born with intrauterine growth retardation.

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The Diagnostic Value of Eeg and Biochemical Markers of Brain Injury in Hypoxic-Ischemic Encephalopathy

Cited by 4 publications

References 1 publication

Optimization of Hypoxic Brain Injuries Diagnostics in Full-Term Newborns

Optimization of Hypoxic Brain Injuries Diagnostics in Full-Term Newborns

Gestational diabetes mellitus and obesity: effects on offspring

Markers of brain damage in full-term newborns with intrauterine growth retardation

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