In this paper, we review a series of studies that we initiated to examine mechanisms of anterior cruciate ligament (ACL) injury in the hope that these injuries, and their sequelae, can be better prevented. First, using the earliest in vitro model of a simulated single-leg jump landing or pivot cut with realistic knee loading rates and trans-knee muscle forces, we identified the worst-case dynamic knee loading that causes the greatest peak ACL strain: Combined knee compression, flexion, and internal tibial rotation. We also identified morphologic factors that help explain individual susceptibility to ACL injury. Second, using the above knee loading, we introduced a possible paradigm shift in ACL research by demonstrating that the human ACL can fail by a sudden rupture in response to repeated sub-maximal knee loading. If that load is repeated often enough over a short time interval, the failure tended to occur proximally, as observed clinically. Third, we emphasize the value of a physical exam of the hip by demonstrating how limited internal axial rotation at the hip both increases the susceptibility to ACL injury in professional athletes, and also increases peak ACL strain during simulated pivot landings, thereby further increasing the risk of ACL fatigue failure. When training at-risk athletes, particularly females with their smaller ACL cross-sections, rationing the number and intensity of worst-case knee loading cycles, such that ligament degradation is within the ACL's ability to remodel, should decrease the risk for ACL rupture due to ligament fatigue failure. Keywords: anterior cruciate ligament; fatigue failure; muscle; tibial rotation; repetitive loading
DIFFERENT APPROACHES FOR STUDYING ACL INJURY MECHANISMSSuccessful injury prevention efforts usually require a detailed understanding of the mechanism(s) of injury. The fact that anterior cruciate ligament (ACL) injuries continue to occur at a high rate in young athletes means that those mechanisms have remained elusive. Many reports of ACL injury describe a noncontact landing from a jump or a pivot maneuver while changing direction.1,2 The direction of movement and body and lower extremity positions have naturally then become the focus of analyzing injury mechanisms. However, while in vivo experiments might seem preferable, we have been reticent to ask athletes to perform the very maneuvers known to cause these injuries for obvious ethical reasons. Adding to our reticence is the fact that all in vivo field studies involve the use of surface markers or sensors that cannot accurately record the underlying skeletal kinematics.3 While animal studies are an alternative option, the external validity of transferring findings from quadrupeds to humans can be problematic. In silico approaches are another alternative but they require physiological kinematic data. That leaves in vitro studies with cadaver limbs as offering potential for exploring ACL injury mechanisms, as long as the rate and type of loading, the presence of muscle forces, and dynamic load...