The Diagnostic Value of Alcohol Dehydrogenase (ADH) Isoenzymes and Aldehyde Dehydrogenase (ALDH) Measurement in the Sera of Colorectal Cancer Patients

Jelski, Wojciech; Mroczko, Barbara; Szmitkowski, Maciej

doi:10.1007/s10620-009-1098-4

Cited by 16 publications

(14 citation statements)

References 19 publications

(23 reference statements)

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“…The area under the ROC curve indicates the clinical usefulness of tested substances. The larger area under the ROC curve signifies a better tumor marker [18]. In this study, the ADH IV (0.67) area under the ROC curve was smaller than tumor markers (CEA, 0.79;), TIMP-1 (0.83) and MMP-9 (0.71).…”

Section: Discussionmentioning

confidence: 51%

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The diagnostic value of alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) measurement in the sera of gastric cancer patients

et al. 2010

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Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) are present in gastric cancer cells (GC). Moreover, the activity of total ADH and class IV isoenzymes is significantly higher in cancer tissue than in healthy mucosa. The activity of these enzymes in cancer cells is probably reflected in the sera and could thus be helpful for diagnostics of gastric cancer. The aim of this study was to investigate a potential role of ADH and ALDH as tumor markers for gastric cancer. We defined diagnostic sensitivity, specificity, predictive value for positive and negative results, and receiver-operating characteristics (ROC) curve for tested enzymes. Serum samples were taken from 168 patients with gastric cancer before treatment and from 168 control subjects. Total ADH activity and class III and IV isoenzymes were measured by photometric but ALDH activity and ADH I and II by the fluorometric method, with class-specific fluorogenic substrates. There was significant increase in the activity of ADH IV isoenzyme and ADH total in the sera of gastric cancer patients compared to the control. The diagnostic sensitivity for ADH IV was 73%, specificity 79%, positive and negative predictive values were 81 and 72% respectively. Area under ROC curve for ADH IV was 0.67. The results suggest a potential role for ADH IV as marker of gastric cancer.

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Section: Discussionmentioning

confidence: 51%

“…Previously, we have found that serum activities of ADH I and ADH total were higher in colorectal cancer (CRC) patients than in healthy subjects and ADH I could be helpful for diagnostic of CRC [18]. This is the first study showing all the diagnostic criteria for alcohol dehydrogenase and aldehyde dehydrogenase in gastric cancer patients.…”

Section: Discussionmentioning

confidence: 73%

The diagnostic value of alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) measurement in the sera of gastric cancer patients

et al. 2010

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“…The differential genes and metabolites on the colorectal cancer data set were mostly located in the pyruvate and lactate metabolism region of the pathway, which was successfully identified by Subpathway-GM (Supplementary Figure S1). Many studies also indicated that this region was closely related to energy demand of colorectal cancer tissues (17,18,34). …”

Section: Resultsmentioning

confidence: 99%

Subpathway-GM: identification of metabolic subpathways via joint power of interesting genes and metabolites and their topologies within pathways

Han

Yao

et al. 2013

Nucleic Acids Research

106

125

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Various ‘omics’ technologies, including microarrays and gas chromatography mass spectrometry, can be used to identify hundreds of interesting genes, proteins and metabolites, such as differential genes, proteins and metabolites associated with diseases. Identifying metabolic pathways has become an invaluable aid to understanding the genes and metabolites associated with studying conditions. However, the classical methods used to identify pathways fail to accurately consider joint power of interesting gene/metabolite and the key regions impacted by them within metabolic pathways. In this study, we propose a powerful analytical method referred to as Subpathway-GM for the identification of metabolic subpathways. This provides a more accurate level of pathway analysis by integrating information from genes and metabolites, and their positions and cascade regions within the given pathway. We analyzed two colorectal cancer and one metastatic prostate cancer data sets and demonstrated that Subpathway-GM was able to identify disease-relevant subpathways whose corresponding entire pathways might be ignored using classical entire pathway identification methods. Further analysis indicated that the power of a joint genes/metabolites and subpathway strategy based on their topologies may play a key role in reliably recalling disease-relevant subpathways and finding novel subpathways.

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“…Isoenzymes of class I ADH are encoded by ADH1A , ADH1B , and ADH1C , whereas class II, III, IV, and class V ADH are encoded by ADH4 , ADH5 , ADH6 , and ADH7 , respectively 19. Numerous studies have shown that the serum levels of class I ADH are a potential diagnostic marker in multiple cancers, including renal cell,20 brain,21 colorectal,22 endometrial,23 and cervical cancers 24. Similar diagnostic values can also be observed in class III ADH for pancreatic cancer,8 and class IV ADH for esophageal25 and gastric cancers 26.…”

Section: Discussionmentioning

confidence: 99%

Distinct prognostic values of alcohol dehydrogenase mRNA expression in pancreatic adenocarcinoma

Liao¹,

Huang²,

Liu³

et al. 2017

OTT

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BackgroundAlcohol dehydrogenase (ADH) isoenzymes have been reported as a potential diagnostic marker for pancreatic cancer, but their prognostic value in pancreatic cancer remains unclear. The aim of this investigation was to identify the prognostic value of ADH genes in human patients with pancreatic adenocarcinoma (PAAD).Materials and methodsAn RNA sequencing dataset and corresponding survival profiles of PAAD were obtained from The Cancer Genome Atlas. Survival analysis and gene set enrichment analysis were used to investigate the prediction value and potential mechanism of ADH genes in PAAD prognosis.ResultsSurvival analysis of ADH genes suggests that a high expression of ADH1A (adjusted P=0.037, adjusted hazard ratio [HR] =0.627, 95% CI =0.404–0.972) and ADH6 (adjusted P=0.018, adjusted HR =0.588, 95% CI =0.378–0.914) were associated with a significantly decreased risk of death, while a high expression of ADH5 was associated with a significantly increased risk of death (adjusted P=0.043, adjusted HR =1.564, 95% CI =1.013–2.414). Joint effects analysis of three ADH gene prognostic markers suggests that the prognosis difference for any marker combination was more significant than that for any individual marker. The potential mechanism of ADH1A and ADH6 in PAAD prognosis was that a high expression of ADH1A and ADH6 was involved in the P450 pathway and biological processes, while high ADH5 expression was involved in transforming growth factor β regulation-related pathways and biological processes, Wnt, the cell cycle, ErbB, and mitogen-activated protein kinase signaling pathways.ConclusionOur data suggest that ADH1A, ADH5, and ADH6 expression may be potential prognostic markers of PAAD and in combination have a strong interaction and better predictive value for PAAD prognosis.

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The Diagnostic Value of Alcohol Dehydrogenase (ADH) Isoenzymes and Aldehyde Dehydrogenase (ALDH) Measurement in the Sera of Colorectal Cancer Patients

Abstract: The results suggest a potential role for ADH I as marker for colorectal cancer.

Cited by 16 publications

References 19 publications

The diagnostic value of alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) measurement in the sera of gastric cancer patients

The diagnostic value of alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) measurement in the sera of gastric cancer patients

Subpathway-GM: identification of metabolic subpathways via joint power of interesting genes and metabolites and their topologies within pathways

Distinct prognostic values of alcohol dehydrogenase mRNA expression in pancreatic adenocarcinoma

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