The Diagnostic Use of Synthetic Lh-Rh (Hoe 471) in Women With Normal and Disturbed Menstrual Function and Under Treatment With Sex-Steroids

Robyn, Claude; Hildebrandt, Herbert; L’Hermite, Marc; Schöndorf, H; Jürgensen, O; Hebauf, H.; Taubert, H.‐D.

doi:10.1530/acta.0.072s088

Cited by 6 publications

(4 citation statements)

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“…Tbe intravenous injection of synthetic TSH-RH and LH-RH affords a reliable method for stimulation of release of TSH andLH (zur Mühlen, Köbberling, Hesch andEmrich 1971, Robyn, Hildebrandt, L 'Hermite, Schöndorf, Jürgensen, Hebauf andTaubert 1973). Accuracy and reliability of the available radioimmunoassay of TSH and LH appear to be sufficient for the investigation of agents having minor effects on hormone secretion.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of Releasing-Hormone-lnduced Secretion of TSH and LH by Calcitonin

Leicht¹,

Bíró²,

Weinges³

1974

Horm Metab Res

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Loss of immunoreactivity of human serum parathyroid hormone by the action of rat kidney enzyme, preferent-ia11y hydrolyzing parathyroid hormone. Horm.Res. 4: 213-218 (1973) &znl, I.M.: Distribution of labeled parathyroid hormone in rat fetus. Horm.Metab.Res. 4: 131-132 (1972) Yl'H-degradation activity in boiled matemal kidney (Table I) would indicate that the observed inactivation of PTH is an enzymatic process rather than due to loss of immunoreactivity by tissue binding.

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Section: Discussionmentioning

confidence: 99%

Inhibition of Releasing-Hormone-lnduced Secretion of TSH and LH by Calcitonin

Leicht¹,

Bíró²,

Weinges³

1974

Horm Metab Res

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“…However, as experience with LH-RH has accumulated, the optimistic ex¬ pectations have not been completely fulfilled. In some patients with organic pituitary lesions, a pituitary response to LH-RH has been reported (Nillius et al 1912b;Robyn et al 1973). On the other hand, the absence of any response in some of our patients with anorexia nervosa and in some cases of isolated pituitary gonadotrophin deficiency (Marshall et al 1972) demonstrates the overlapping of the pituitary response to LH-RH in functional and organic diseases of the hypothalamic-pituitary system.…”

Section: Discussionmentioning

confidence: 99%

“…The effect of LH-RH administration on the gonadotrophin output in humans has been studied in a number of physio¬ logical and pathological conditions (Nillius 8c Wide 1912a,b;Yen et al , 1973Roth et al 1972), but its value for diagnostic and therapeutic purposes needs further documentation. Although it has been anticipated that the LH-RH stimulation test would allow the differentiation between functional amenorrhea and amenorrhea due to organic pituitary disease, this proved not to hold in all cases since a definite response of LH in some cases of pituitary adenoma has been reported (Nillius 8c Wide 1912b;Robyn et al 1973).…”

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confidence: 99%

Diagnostic Value of the Lh-Releasing Hormone Stimulation Test in Functional Amenorrhea

Vandekerckhove

Dhont

Eyck

1975

Acta Endocrinologica

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LH-releasing hormone (25 \g=m\g,iv.) was administered to 37 women with functional amenorrhea. In addition to the clinical classification, these patients were divided into three groups according to the basal level of serum LH. A significant correlation was found between the base-line levels of LH and the serum concentration of oestradiol plus oestrone. The absolute increment of LH after the injection of LH-RH was found to be dependent only on the base-line level of LH. Except for the patients with anorexia nervosa, the base-line levels and the response pattern of FSH were almost the same for all three groups.From the results of this study, it was concluded that: 1. The circulating levels of oestradiol and oestrone, where derived from ovarian secretion, actually depend on the gonadotrophic stimulus. In patients with functional amenorrhea, the oestrogens do not make an independent contribution to the pituitary response to LH-RH. 2. Dysregulation of releasing hormones, whether located at the hypothalamic or suprahypothalamic level, necessarily influences the secretory capacity of the pituitary gland; long-standing deficiency of LH-RH may finally lead to a state of pituitary "functional" unresponsiveness to releasing hormones.3. In view of the excellent correlation between the base-line levels of LH and the absolute increment of LH following stimulation with LH-RH, this test only accentuates the existing pituitary secretory capacity, which can be roughly estimated from the circulating levels of LH and FSH. 4. This test may be useful in distinguishing the milder cases of psychogenic amenorrhea from extreme gonadotrophic dysfunction in patients with anorexia nervosa.

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“…Elevated levels of circulating steroids hormones in pregnant women could likely be responsible for this inhibition. The feed-back -time and dose dependent -of steroid hormones on gonadotrophins secretion has been largely documented by clinical and experimental studies using various oestroprogrestative treatment including oral contraceptives (Robyn et al 1973;LemarchandBéraud et al 1974;Perez-Lopez et al 1975;Keyes 8c Jaffe 1975; Young 8c Jaffe 1976; Jaffe 8c Keyes 1975;Gual et al 1975;Yen et al 1975).…”

Section: Tsh Responsivenessmentioning

confidence: 99%

Thyroliberin and Gonadoliberin Tests During Pregnancy and the Puerperium

Vandalem

Pirens

Hennen

et al. 1977

Acta Endocrinologica

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Highly specific and sensitive radioimmunoassays for HTSH, HFSH and HLH have been used in order to investigate pituitary thyrotrophic and gonadotrophic functions of pregnant and puerperal women. The radioimmunoassay system for HFSH, using reagents prepared in our laboratory, is described.Thirty-three women were studied during pregnancy and post-partum. Forty-one TRH tests were performed. Basal levels of TSH, and increase in serum TSH after intravenous injection of TRH were similar in pregnant and puerperal women and in a control group. Thirty-three LH-RH tests were also performed. Basal levels of LH and FSH remained undetectable throughout pregnancy and in early puerperium. Furthermore, after intravenous injection of LH-RH neither LH nor FSH activity could be detected.It has thus been demonstrated that pituitary responsiveness to TRH during pregnancy and the puerperium is similar to that of non-pregnant young women. In contrast, a complete cessation of pituitary gonadotrophic functions is observed during the same period.Due to an important degree of structural homology, antigenic relationships exist between human pituitary and chorionic glycoprotein hormones (human thyrotrophin: HTSH, human follitrophin: HFSH, human lutrophin: HLH and human chorionic gonadotrophin: HCG). This explains many of the difficulties Laboratoire d'Endocrinologie,

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The Diagnostic Use of Synthetic Lh-Rh (Hoe 471) in Women With Normal and Disturbed Menstrual Function and Under Treatment With Sex-Steroids

Cited by 6 publications

References 0 publications

Inhibition of Releasing-Hormone-lnduced Secretion of TSH and LH by Calcitonin

Inhibition of Releasing-Hormone-lnduced Secretion of TSH and LH by Calcitonin

Diagnostic Value of the Lh-Releasing Hormone Stimulation Test in Functional Amenorrhea

Thyroliberin and Gonadoliberin Tests During Pregnancy and the Puerperium

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