The diagnostic accuracy of urine IgG antibody tests for the detection of Helicobacter pylori infection in Turkish dyspeptic patients

Gürbüz, Ebru Demiray; Gönen, Can; Bekmen, Neslihan; Dolek, Devrim; Soytürk, Müjde; Sağol, Özgül; Şımşek, İlkay; Yılmaz, Özlem

doi:10.4318/tjg.2012.0497

Cited by 5 publications

(2 citation statements)

References 25 publications

(70 reference statements)

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“…Therefore, it is better to develop a test kit by using local strains as the source of antigen to obtain the best performance. The urinary tests were also evaluated in Turkish subjects [18]. The sensitivity and specificity of URINELISA were 74.4 and 81.0%, respectively, and those of RAPIRUN were 73.2 and 78.6%, respectively.…”

Section: Anti-h Pylori Antibodymentioning

confidence: 99%

Biomarkers for Helicobacter Pylori Infection and Gastroduodenal Diseases

Shiota

Yamaoka

2014

Biomark. Med.

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Helicobacter pylori infection is a major cause of gastric cancer. Although identifying H. pylori infected subjects is the first approach for delineating the high-risk population for gastric cancer, the presence of H. pylori antibodies is not sufficient for gastric cancer screening. Among H. pylori infected subjects, only a minority of infected individuals develop gastric cancer. Serologic markers of H. pylori infection can serve as potential predictors for the development of gastric cancer. Serum or urinary H. pylori antibodies, cytotoxin-associated gene A antibodies, pepsinogen and microRNAs were reported to be associated with precancerous lesions or gastric cancer. In this review, we summarized the utilities and limitations of each strategy.

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Section: Anti-h Pylori Antibodymentioning

confidence: 99%

Biomarkers for Helicobacter Pylori Infection and Gastroduodenal Diseases

Shiota

Yamaoka

2014

Biomark. Med.

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“…Sensitivity and specificity in adults were 89.4% and 68%, respectively, 12 and the corresponding figures in children were 63.2% and 97.3%, respectively. 13 Subsequently, the accuracy and usefulness of the IM assay have been supported by several trials in different geographical areas, including Japan 14 , Turkey, 15 Hong Kong and Taiwan, 16 the USA, 17 and Europe. 18 …”

Section: Introductionmentioning

confidence: 96%

Accuracy of testing for anti-Helicobacter pyloriIgG in urine forH. pyloriinfection diagnosis: a systematic review and meta-analysis

Gong

Yuan

2017

BMJ Open

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ObjectivesThis meta-analysis aims to systematically measure the potential diagnostic value of anti-Helicobacter pylori IgG in urine for infection diagnosis, using all eligible studies published in English and Chinese languages.DesignThe random effect model was used to analyse the pooled sensitivity, specificity, positive likelihood ratio (PLR), negative LR (NLR), diagnostic OR (DOR), together with the summary receiver operator characteristic curve.SettingLiterature searches of databases including PubMed, EMBASE, MEDLINE, Web of Science, Chinese National Knowledge Infrastructure and Wanfang databases were performed to retrieve studies evaluating the diagnostic value of urine IgG antibody for H.pylori infection.Primary outcome measureTwenty-three studies with 4963 subjects were included in the current meta-analysis.ResultsThe pooled sensitivity, specificity, PLR, NLR, DOR and area under the curve (AUC) were 0.83 (95% CI 0.82 to 0.85), 0.89 (95% CI 0.88 to 0.90), 8.81 (95% CI 6.37 to 12.2), 0.13 (95% CI 0.09 to 0.2), 73 (95% CI 46.45 to 114.74) and 0.9551, respectively. Subgroup analyses showed that diagnostic accuracy of the urine IgG assay was no different in age, region, study population and assay method.ConclusionsAnti-H. pylori antibody in urine might serve as a good marker in diagnosing H. pylori infection. However, further validation based on a larger sample is still required.

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Non-invasive diagnostic tests forHelicobacter pyloriinfection

Best

Takwoingi

Siddique

et al. 2018

Cochrane Database of Systematic Reviews

153

130

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In people without a history of gastrectomy and those who have not recently had antibiotics or proton ,pump inhibitors, urea breath tests had high diagnostic accuracy while serology and stool antigen tests were less accurate for diagnosis of Helicobacter pylori infection.This is based on an indirect test comparison (with potential for bias due to confounding), as evidence from direct comparisons was limited or unavailable. The thresholds used for these tests were highly variable and we were unable to identify specific thresholds that might be useful in clinical practice.We need further comparative studies of high methodological quality to obtain more reliable evidence of relative accuracy between the tests. Such studies should be conducted prospectively in a representative spectrum of participants and clearly reported to ensure low risk of bias. Most importantly, studies should prespecify and clearly report thresholds used, and should avoid inappropriate exclusions.

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The diagnostic accuracy of urine IgG antibody tests for the detection of Helicobacter pylori infection in Turkish dyspeptic patients

Cited by 5 publications

References 25 publications

Biomarkers for Helicobacter Pylori Infection and Gastroduodenal Diseases

Biomarkers for Helicobacter Pylori Infection and Gastroduodenal Diseases

Accuracy of testing for anti-Helicobacter pyloriIgG in urine forH. pyloriinfection diagnosis: a systematic review and meta-analysis

Non-invasive diagnostic tests forHelicobacter pyloriinfection

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