Accuracy of testing for anti-Helicobacter pyloriIgG in urine forH. pyloriinfection diagnosis: a systematic review and meta-analysis

Abstract

ObjectivesThis meta-analysis aims to systematically measure the potential diagnostic value of anti-Helicobacter pylori IgG in urine for infection diagnosis, using all eligible studies published in English and Chinese languages.DesignThe random effect model was used to analyse the pooled sensitivity, specificity, positive likelihood ratio (PLR), negative LR (NLR), diagnostic OR (DOR), together with the summary receiver operator characteristic curve.SettingLiterature searches of databases including PubMed, EMBASE, MEDLINE, Web of Science, Chinese National Knowledge Infrastructure and Wanfang databases were performed to retrieve studies evaluating the diagnostic value of urine IgG antibody for H.pylori infection.Primary outcome measureTwenty-three studies with 4963 subjects were included in the current meta-analysis.ResultsThe pooled sensitivity, specificity, PLR, NLR, DOR and area under the curve (AUC) were 0.83 (95% CI 0.82 to 0.85), 0.89 (95% CI 0.88 to 0.90), 8.81 (95% CI 6.37 to 12.2), 0.13 (95% CI 0.09 to 0.2), 73 (95% CI 46.45 to 114.74) and 0.9551, respectively. Subgroup analyses showed that diagnostic accuracy of the urine IgG assay was no different in age, region, study population and assay method.ConclusionsAnti-H. pylori antibody in urine might serve as a good marker in diagnosing H. pylori infection. However, further validation based on a larger sample is still required.

Diet and rosacea: the role of dietary change in the management of rosacea

“…Specifically, SIBO can be detected using a lactulose and glucose H2/CH4 breath test [ 27 , 35 , 36 ], although reports indicate a wide range of sensitivity and specificity [ 37 ]. Similarly, H. pylori can be diagnosed with noninvasive urea breath tests, stool antigen test, and serum/urine antibody tests [ 38 ]. The urea breath test, in particular, has a high reported sensitivity and specificity [ 39 ].…”

Detecting anti–SARS-CoV-2 antibodies in urine samples: A noninvasive and sensitive way to assay COVID-19 immune conversion

“…It has been known since the mid-1950s that -globulins can be detected in urine (10,13). Although not widely studied or reported, urinebased diagnostic tests that detect antibodies have been suggested as a possible noninvasive alternative to diagnose several conditions, such as dengue, Helicobacter pylori infection, hepatitis A and C, human immunodeficiency virus, strongyloidiasis, schistosomiasis, paragonimiasis, and leishmaniasis (11)(12)(13)(14)(15)(16)(17)(18)(19)(20). To the best of our knowledge, there is no published study on detecting anti-SARS-CoV-2 antibodies in urine.…”

Diagnostic approach to Helicobacter pylori-related gastric oncogenesis

“…A large number of methods have also been developed for the noninvasive detection of H. pylori infection through spotting of anti- H. pylori IgG or IgA antibodies in blood, serum, saliva and urine [ 128 ]. Regarding the detection of H. pylori infection in urine, a large meta-analysis, including 23 studies and 4963 patients, reported that testing for anti- H. pylori antibodies in urine could be a valuable marker in the diagnosis of H. pylori infection [ 129 ]. However, tests for IgG in urine may remain positive over a long period of time after the therapy of the H. pylori infection, an acknowledged drawback of the method [ 128 ].…”