The diagnostic accuracy of spectral-domain optical coherence tomography for neovascular age-related macular degeneration: a comparison with fundus fluorescein angiography

Wilde, Craig; Patel, Manju; Lakshmanan, Arun; Amankwah, Ruby; Dhar-Munshi, Sushma; Amoaku, Winfried

doi:10.1038/eye.2015.44

Cited by 51 publications

(45 citation statements)

References 23 publications

(29 reference statements)

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“…Interestingly, structural SD-OCT alone also had a sensitivity of 100% for both graders, findings similar to other studies. 26–28 However, the high sensitivity of structural OCT was associated with a lower specificity in this series, findings also consistent with other studies, which have reported a wide range of specificity at 47%, 81%, and 98% for CNV detection. 26–28 Graders in this study could only classify CNV as present if flow was detected in the outer retina that was distinct from projection artifact with cross-sectional OCTA, resulting in improved specificity compared to structural OCT.…”

Section: Discussionsupporting

confidence: 91%

Sensitivity and Specificity of OCT Angiography to Detect Choroidal Neovascularization

Faridi

Jia

Gao

et al. 2017

Ophthalmology Retina

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Purpose To determine the sensitivity and specificity of optical coherence tomography angiography (OCTA) in the detection of choroidal neovascularization (CNV) in age-related macular degeneration (AMD). Design Prospective case series. Subjects Prospective series of seventy-two eyes were studied, which included eyes with treatment-naive CNV due to AMD, non-neovascular AMD, and normal controls. Methods All eyes underwent OCTA with a spectral domain (SD) OCT (Optovue, Inc.). The 3D angiogram was segmented into separate en face views including the inner retinal angiogram, outer retinal angiogram, and choriocapillaris angiogram. Detection of abnormal flow in the outer retina served as candidate CNV with OCTA. Masked graders reviewed structural OCT alone, en face OCTA alone, and en face OCTA combined with cross-sectional OCTA for the presence of CNV. Main Outcome Measure The sensitivity and specificity of CNV detection compared to the gold standard of fluorescein angiography (FA) and OCT was determined for structural SD-OCT alone, en face OCTA alone, and with en face OCTA combined with cross-sectional OCTA. Results Of 32 eyes with CNV, both graders identified 26 true positives with en face OCTA alone, resulting in a sensitivity of 81.3%. Four of the 6 false negatives had large subretinal hemorrhage (SRH) and sensitivity improved to 94% for both graders if eyes with SRH were excluded. The addition of cross-sectional OCTA along with en face OCTA improved the sensitivity to 100% for both graders. Structural OCT alone also had a sensitivity of 100%. The specificity of en face OCTA alone was 92.5% for grader A and 97.5% for grader B. The specificity of structural OCT alone was 97.5% for grader A and 85% for grader B. Cross-sectional OCTA combined with en face OCTA had a specificity of 97.5% for grader A and 100% for grader B. Conclusions Sensitivity and specificity for CNV detection with en face OCTA combined with cross-sectional OCTA approaches that of the gold standard of FA with OCT, and it is better than en face OCTA alone. Structural OCT alone has excellent sensitivity for CNV detection. False positives from structural OCT can be mitigated with the addition of flow information with OCTA.

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Section: Discussionsupporting

confidence: 91%

Sensitivity and Specificity of OCT Angiography to Detect Choroidal Neovascularization

Faridi

Jia

Gao

et al. 2017

Ophthalmology Retina

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“…When comparing OCT, FA and OCT‐A, the highest diagnostic accuracy to detect a CNV was identified for OCT, in particular when images from previous visits were available for comparison. This is consistent with previous studies which showed a sensitivity up to 100% for CNV detection based on structural OCT . Although OCT‐A and FA obtained almost similar kappa values in our study (0.39 vs 0.37) and may, therefore, be considered equivalent, different sensitivity and specificity values need to be taken into account.…”

Section: Discussionsupporting

confidence: 91%

Retinal imaging including optical coherence tomography angiography for detecting active choroidal neovascularization in pseudoxanthoma elasticum

Birtel

Lindner

Mishra

et al. 2018

Clinical Exper Ophthalmology

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“…[1][2][3] Microscopic fundus examination, optical coherence tomography (OCT), fluorescein angiography (FA), and indocyanine green angiography (ICGA) are useful for diagnosing eyes with PCV. [4][5][6][7][8][9][10][11] FA and ICGA are invasive techniques that require intravenous dye injection, and hepatic, renal, or allergic complications can arise. 12 In terms of severe reactions, cases of hypotensive shock and death have been reported.…”

Section: Introductionmentioning

confidence: 99%

Comparison of indocyanine green angiography and optical coherence tomographic angiography in polypoidal choroidal vasculopathy

Takayama

Ito

Kaneko

et al. 2016

Eye

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PurposeTo compare optical coherence tomographic angiography (OCTA) and indocyanine green angiography (ICGA) images for detecting polypoidal lesions (PLs) and branching vascular networks (BVNs), and to measure the polypoidal areas (PAs) in patients with polypoidal choroidal vasculopathy (PCV).MethodsAll patients underwent ICGA, optical coherence tomography (OCT), and OCTA. We compared the detection sensitivity for PL and BVN, as evaluated by the ICGA and OCTA images. Furthermore, PA measured by ICGA was divided into two groups: one in which the area could be measured by OCTA (ICGAOCTA) and the other in which the area could not be measured by OCTA (ICGAOCTA).ResultsTwenty-one consecutive eyes of 21 patients (mean age, 73.8±9.8 years) were included. ICGA detected PL in all eyes (100%), whereas OCTA detected PL in 16 eyes (75.2%); ICGA detected BVN in 15 eyes (71.4%), whereas OCTA detected BVN in 20 eyes (95.2%). The mean PA in ICGAOCTA and ICGAOCTA was 0.24±0.04 and 0.14±0.01 mm, respectively; a significant difference was observed between ICGAOCTA PA and ICGAOCTA PA (P<0.0001). In addition, the mean PA in the ICGAOCTA group measured by ICGA and OCTA was 0.24±0.04 was 0.19±0.04 mm, respectively; these values were significantly different (P=0.0046).ConclusionsOCTA might detect more BVNs and fewer PLs compared with ICGA, and PL detected by OCTA might be smaller than those detected by ICGA.

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The diagnostic accuracy of spectral-domain optical coherence tomography for neovascular age-related macular degeneration: a comparison with fundus fluorescein angiography

Cited by 51 publications

References 23 publications

Sensitivity and Specificity of OCT Angiography to Detect Choroidal Neovascularization

Sensitivity and Specificity of OCT Angiography to Detect Choroidal Neovascularization

Retinal imaging including optical coherence tomography angiography for detecting active choroidal neovascularization in pseudoxanthoma elasticum

Comparison of indocyanine green angiography and optical coherence tomographic angiography in polypoidal choroidal vasculopathy

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