Comparison of indocyanine green angiography and optical coherence tomographic angiography in polypoidal choroidal vasculopathy

Abstract

PurposeTo compare optical coherence tomographic angiography (OCTA) and indocyanine green angiography (ICGA) images for detecting polypoidal lesions (PLs) and branching vascular networks (BVNs), and to measure the polypoidal areas (PAs) in patients with polypoidal choroidal vasculopathy (PCV).MethodsAll patients underwent ICGA, optical coherence tomography (OCT), and OCTA. We compared the detection sensitivity for PL and BVN, as evaluated by the ICGA and OCTA images. Furthermore, PA measured by ICGA was divided into two groups: one in which the area could be measured by OCTA (ICGAOCTA) and the other in which the area could not be measured by OCTA (ICGAOCTA).ResultsTwenty-one consecutive eyes of 21 patients (mean age, 73.8±9.8 years) were included. ICGA detected PL in all eyes (100%), whereas OCTA detected PL in 16 eyes (75.2%); ICGA detected BVN in 15 eyes (71.4%), whereas OCTA detected BVN in 20 eyes (95.2%). The mean PA in ICGAOCTA and ICGAOCTA was 0.24±0.04 and 0.14±0.01 mm, respectively; a significant difference was observed between ICGAOCTA PA and ICGAOCTA PA (P<0.0001). In addition, the mean PA in the ICGAOCTA group measured by ICGA and OCTA was 0.24±0.04 was 0.19±0.04 mm, respectively; these values were significantly different (P=0.0046).ConclusionsOCTA might detect more BVNs and fewer PLs compared with ICGA, and PL detected by OCTA might be smaller than those detected by ICGA.

Comparison of SD-Optical Coherence Tomography Angiography and Indocyanine Green Angiography in Type 1 and 2 Neovascular Age-related Macular Degeneration

“…3 and 4). This finding confirms previous studies in eyes with PCV and type 1 nAMD, where lesion sizes were statistically significantly smaller in OCTA than in ICGA 26,27 without the systematic approach used in our study differentiating between lesion types.…”

“…A higher sampling density in a smaller volume (3 3 3 mm) could potentially increase CNV detection. Yet, previous studies 26,27 showed the same results, namely larger CNV-A in FA and ICGA compared with OCTA.…”

“…18,20 Despite the evident benefits of OCTA, 21,22 it has not found its way into primary nAMD diagnosis, and treatment guidelines and FA/ICGA are still considered the gold standard for a comprehensive evaluation of lesion location and morphology. [11][12][13] Current efforts to fully explore and understand the capabilities of OCTA and to set the basis for future diagnostic and therapeutic criteria in nAMD include comparisons of FA and OCTA, [23][24][25] as well as ICGA and OCTA [26][27][28] with variable conclusions.…”

Increased Retinal Thinning after Combination of Internal Limiting Membrane Peeling and Silicone Oil Endotamponade in Proliferative Diabetic Retinopathy

“…On the other hand, in the study using 3-dimensional OCT, Hisatomi et al [35] discussed the possibility that the temporal macular thinning would in some cases be due to the damage of the retinal nerve fiber layer by incision and grasping during ILM peeling in eyes with retinal detachment. Recently, many physicians have been focusing on the diagnostic potential of OCT angiography, a state-ofthe-art technique that can provide noninvasive imaging of the retinal vascular network [36,37] . There is a possibility that we will obtain many new findings with regard to the effects of ILM peeling and SO endotamponade on retinal thinning by analysis using OCT angiography.…”

Spectral-Domain Optical Coherence Tomography Angiography for the Diagnosis and Evaluation of Polypoidal Choroidal Vasculopathy

“…A few small case series have shown that OCTA can demonstrate the BVN in most cases but has difficulty showing polyps as they may appear as hypoflow lesions [25][26][27][28]. Two slightly larger case studies in Japan noted that OCTA is able to detect the BVN and polyps in about 75-85% of eyes [29,30]. However, these prior studies were limited by small sample sizes of 21 eyes or fewer.…”