The diagnostic accuracy of OCT angiography in naive and treated neovascular age-related macular degeneration: a review

Abstract

Optical coherence tomography angiography (OCTA) is a non-invasive retinal imaging innovation that has been gaining popularity for the evaluation of the retinal vasculature. Of clinical importance is its current use either as an alternative or in conjunction with conventional dye-based angiography in neovascular age-related macular degeneration. OCTA is not without limitations and these include image artefact, a relatively small field of view and failure of the segmentation algorithms, which can confound the interpretation of findings. While there are numerous publications on OCTA in neovascular AMD, few have examined the diagnostic accuracy of this new technology compared with the accepted gold standard of fundus fluorescein angiography (FFA). In this review, we summarise the literature on the clinical application of OCTA in nAMD. In particular, we have reviewed the published articles that have reported the sensitivity and specificity of OCTA in the diagnosis of nAMD, and those that have described and or correlated the morphological findings and compared them to dye-based angiography.

Microglia Contribution to the Regulation of the Retinal and Choroidal Vasculature in Age-Related Macular Degeneration

“…The retina has the particularity of being the only tissue in the human body for which deep vasculature can be visualized directly and in a non-invasive way using, for example, optical coherence tomography angiography (OCTA), presenting a unique opportunity to study vascular alterations in eye diseases [17,18].…”

Oct angiography compared to fluorescein angiography, indocyanine green angiography and optical coherence tomography in the detection of choroidal neovascularization in pigment epithelial detachment

“…Previous studies have shown the diagnostic accuracy of OCTA compared to traditional methods of detecting CNV, with sensitivity ranging from 50% to 86.5% (Perrott‐Reynolds et al. ). Carnevali et al.…”

Quantitative Evaluation of Superficial Retinal Capillary Area via Optical Coherence Tomography in Healthy Individuals in Turkish Population

“…Sinyal derinliği arttıkça derin oküler yapıların görüntülenmesi kolaylaş- makta ve segmentasyon algoritmaları geliştikçe de farklı retina dolaşım sahâlârı daha net olarak görüntülenebilmektedir. Hazır olan OKTA sistemleri ile yüzeysel retina dolaşımı, derin retina dolaşımı ve koroidal dolaşım ayrıştırılabilmektedir (2,(9)(10)(11)(12) . Tüm bu gelişmeler oldukça hızlı gerçekleşmiş ve gerek donanımsal gerekse yazılımsal gelişmeler sonucunda OKTA ölçümleri sonrası kantitatif analizler yapılabilir hâle gelmiştir.…”