The diagnosis values of serum STAT4 and sEng in preeclampsia

Zhang, Luyan; Li, Xuechun; Zhou, Chengcheng; You, Zhengming; Zhang, Jianwei; Cao, Guomei

doi:10.1002/jcla.23073

Cited by 10 publications

(7 citation statements)

References 40 publications

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“…Furtherly, it suggests that inflammatory response regulation is impaired in preeclamptic women.Signal transducer and activator of transcription 4(STAT4)mediates extracellular signals of inflammatory mediators by regulate the biological behavior of immune cells [23]. A small number of studies [24][25][26][27] have reported that STAT4 expression is significantly elevated in patients with preeclampsia, which is also consistent with our study. STAT4 can act on vascular endothelial cells, causing cell dysfunction, which further causes the development of preeclampsia.…”

Section: Discussionsupporting

confidence: 91%

Identification and prediction of potential crucial genes and therapeutic drugs associated with preeclampsia

Huang

Zhao²

2022

Preprint

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Background: Preeclampsia is a specific disease related to pregnancy that can cause severe maternal and fetal complications and is one of the leading causes of maternal and perinatal deaths. But its pathogenesis is not yet clear. Objective: This study aimed to explore the potential genes and small molecule drugs of preeclampsia. Methods: Gene expression profile(GSE160888) was acquired from the NCBI Gene Expression Omnibus. The microarray data included Preeclampsia, placenta, and normal placenta, which were analyzed to identify differentially expressed genes (DEGs) by R. The PPI network was constructed by using the STRING online database.The module analysis of PPI in MCODE screened out protein interaction modules. Then, Using R, these modules were analyzed again by using KEGG and GO enrichment analysis. Prediction of small-molecule drugs performed by CAMP. Finally, GSE102897 was used to verify the identified Hub genes. Results: A total of 821 genes were identified after standardizing the microarray results, consisting genes of 416 upregulated and 405 downregulated. In total, two modules were identified, and five genes and five small-molecule drugs were selected. Conclusion: In summary, we identified five hub genes that may be involved in the development and development of preeclampsia and screened out five potential small molecule drugs that have some significance for the treatment of preeclampsia.

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Section: Discussionsupporting

confidence: 91%

Identification and prediction of potential crucial genes and therapeutic drugs associated with preeclampsia

Huang

Zhao²

2022

Preprint

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“…STAT4 , which encodes the signal transducer and activator of transcription 4, is a key activator of immune regulating genes and was upregulated in R3 and AI placentas compared to Controls. STAT4 mediated pathways are disrupted in preeclampsia and circulating levels are elevated in patients with preeclampsia ( 46, 47 ). This differential gene expression was only seen in the placenta if the maternal infection was active or recently resolved, suggesting a long period of time is necessary to attenuate these pathways.…”

Section: Resultsmentioning

confidence: 99%

Extracellular vesicles alter trophoblast function in pregnancies complicated by COVID-19

Golden,

Mani,

Linn

et al. 2024

Preprint

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SARS-CoV-2 infection and the resulting coronavirus disease (COVID-19) complicate pregnancies as the result of placental dysfunction which increases the risk of adverse pregnancy outcomes. While abnormal placental pathology resulting from COVID-19 is common, direct infection of the placenta is rare. This suggests maternal response to infection is responsible for placental dysfunction. We hypothesized that maternal circulating extracellular vesicles (EVs) are altered by COVID-19 during pregnancy and contribute to placental dysfunction. To examine this, we characterized maternal circulating EVs from pregnancies complicated by COVID-19 and tested their functional effect on trophoblast cells in vitro. We found the timing of infection is a major determinant of the effect of COVID-19 on circulating EVs. Additionally, we found differentially expressed EV mRNA cargo in COVID-19 groups compared to Controls that regulates the differential gene expression induced by COVID-19 in the placenta. In vitro exposure of trophoblasts to EVs isolated from patients with an active infection, but not EVs isolated from Controls, reduced key trophoblast functions including hormone production and invasion. This demonstrates circulating EVs from subjects with an active infection disrupt vital trophoblast function. This study determined that COVID-19 has a long-lasting effect on circulating EVs and circulating EVs are likely to participate in the placental dysfunction induced by COVID-19.

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“…Therefore, understanding the link between LIF and the pathogenic mechanisms of preeclampsia may contribute to the development of effective treatments for preeclampsia ( 64 ). Additionally, studies have shown that elevated expression of STAT4 in the serum of preeclampsia patients could act as a diagnostic indicator for the severity of the disease ( 65 ).…”

Section: The Role Of the Stat Signaling Pathway In Pregnancy-related ...mentioning

confidence: 99%

Research progress on the STAT signaling pathway in pregnancy and pregnancy-associated disorders

Li,

Zhang,

et al. 2024

Front. Immunol.

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Signal transducer and activator of transcription (STAT) proteins, pivotal regulators of signaling cascades, undergo activation in response to the stimulation of cytokines and growth factors, and participate in biological processes, including inflammation, immune responses, cell proliferation, and differentiation. During the process of pregnancy, STAT signaling is involved in regulating embryonic implantation, endometrial decidualization, and establishing and maintaining maternal-fetal immune tolerance. Increasing evidence suggests that aberrant STAT signaling contributes to the occurrence and development of pregnancy disorders, including repeated implantation failure (RIF), preeclampsia (PE), recurrent spontaneous abortion (RSA), preterm birth (PTB) and gestational diabetes mellitus (GDM). Elucidating the molecular mechanisms of the STAT signaling pathway holds promise for further understanding the establishment and maintenance of normal pregnancy, and thereby providing potent targets and strategic avenues for the prevention and management of ailments associated with pregnancy. In this review, we summarized the roles of the STAT signaling pathway and its related regulatory function in embryonic implantation, endometrial decidualization, and maternal-fetal immune tolerance. In conclusion, in-depth research on the mechanism of the STAT signaling pathway not only enhances our understanding of normal pregnancy processes but also offers STAT-based therapeutic approaches to protect women from the burden of pregnancy-related disorders.

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The diagnosis values of serum STAT4 and sEng in preeclampsia

Cited by 10 publications

References 40 publications

Identification and prediction of potential crucial genes and therapeutic drugs associated with preeclampsia

Identification and prediction of potential crucial genes and therapeutic drugs associated with preeclampsia

Extracellular vesicles alter trophoblast function in pregnancies complicated by COVID-19

Research progress on the STAT signaling pathway in pregnancy and pregnancy-associated disorders

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