Introduction: Autism spectrum disorder (ASD) is a complicated mental disorder and the etiology is still unknown. Several studies showed the possibilities of prenatal and neonatal factors becoming risks for ASD. This study aimed to identify the possibilities of risk factors in prenatal and neonatal condition that could be related with ASD.Methods: This research was a case control study in the Banyumas District Area, Province of Central Java, Indonesia. It included 52 children with ASD as the case group and 201 normal children as the control group. Data were collected with demographic tools with questions about prenatal and neonatal factors. Analyzed data used Chi-Square, Fisher Exact tests, and Regression Logistic analyses.Results: This study found that father with active smoking, high-income in socio-economic status, mother with passive smoking during pregnancy, multipara mother, and history of neonatus CPR significantly increased the risk to have children with ASD (p=0.000, OR: 0.256; p=0.000, OR: 3,23; p=0.032; OR:0.490; p=0.019, OR: 2.15; p=0.000; OR:11.760). Other factors such as history of antenatal care, history of gestation complication and newborn weight were not significantly correlated with ASD (p>0.05).
Conclusions:Father with active smoking, high income in socio-economic status, mother with passive smoking during pregnancy, multipara mother and history of neonatus CPR were risk factors for ASD.Recommendations: Additional studies are needed to identify the possibilities of other prenatal and postnatal factors in ASD.