The diagnosis and treatment of osteosarcoma and Ewing’s sarcoma in children and adolescents

Zarghooni, Kourosh; Bratke, Grischa; Landgraf, Pablo; Simon, Thorsten; Maintz, David; Eysel, Peer

doi:10.3238/arztebl.m2023.0079

Cited by 6 publications

(4 citation statements)

References 48 publications

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“…Pediatric OS, usually occurs in children and adolescents. 125 HCG18 promotes the progression of childhood OS by affecting OS cell viability, migration and invasion. FOXC1 belongs to the FOX family and has been shown to promote the proliferation and migration of cancer cells.…”

Section: Osteosarcoma (Os)mentioning

confidence: 99%

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The role of lncRNA HCG18 in human diseases

Long,

Zhou,

Zhang

et al. 2024

Cell Biochemistry & Function

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A substantial number of long noncoding RNAs (lncRNAs) have been identified as potent regulators of human disease. Human leukocyte antigen complex group 18 (HCG18) is a new type of lncRNA that has recently been proven to play an important role in the occurrence and development of various diseases. Studies have found that abnormal expression of HCG18 is closely related to the clinicopathological characteristics of many diseases. More importantly, HCG18 was also found to promote disease progression by affecting a series of cell biological processes. This article mainly discusses the expression characteristics, clinical characteristics, biological effects and related regulatory mechanisms of HCG18 in different human diseases, providing a scientific theoretical basis for its early clinical application.

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Section: Osteosarcoma (Os)mentioning

confidence: 99%

“…Pediatric OS, usually occurs in children and adolescents 125 . HCG18 promotes the progression of childhood OS by affecting OS cell viability, migration and invasion.…”

Section: Hcg18 In Human Diseasementioning

confidence: 99%

The role of lncRNA HCG18 in human diseases

Long,

Zhou,

Zhang

et al. 2024

Cell Biochemistry & Function

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“…Advanced and metastatic disease develops in 25% of patients despite standard-of-care therapy. 5–9 Long-term survival rates for these cases stagnate around 20-40%. 5,7,10 Osteosarcoma typically forms due to sporadic mutations, often those leading to loss of tumor suppressor function and diverse phenotypic heterogeneity that supports tumor survival and metastasis.…”

Section: Introductionmentioning

confidence: 99%

Trabectedin Enhances Oncolytic Virotherapy by Reducing Barriers to Virus Spread and Cytotoxic Immunity in Preclinical Pediatric Bone Sarcoma

Ringwalt,

Currier,

Glaspell

et al. 2024

Preprint

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We previously reported that the DNA alkylator and transcriptional-blocking chemotherapeutic agent trabectedin enhances oncolytic herpes simplex viroimmunotherapy in human sarcoma xenograft models, though the mechanism remained to be elucidated. Here we report trabectedin disrupts the intrinsic cellular anti-viral response which increases viral transcript spread throughout the human tumor cells. We also extended our synergy findings to syngeneic murine sarcoma models, which are poorly susceptible to virus infection. In the absence of robust virus replication, we found trabectedin enhanced viroimmunotherapy efficacy by reducing immunosuppressive macrophages and stimulating granzyme expression in infiltrating T and NK cells to cause immune-mediated tumor regressions. Thus, trabectedin enhances both the direct virus-mediated killing of tumor cells and the viral-induced activation of cytotoxic effector lymphocytes to cause tumor regressions across models. Our data provide a strong rationale for clinical translation as both mechanisms should be simultaneously active in human patients.

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“…The incidence of OS peaks around puberty, with an overall incidence of 3.8 per 1,000,000 people, with males slightly outnumbering females. ( Zarghooni et al, 2023 ). OS mostly occurs in the extremities, especially in the distal femur, proximal tibia, and proximal fibula.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive transcriptomic analysis identifies SLC25A4 as a key predictor of prognosis in osteosarcoma

Zhang,

Wang,

Zhang

et al. 2024

Front. Genet.

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BackgroundOsteosarcoma (OS) is highly malignant and prone to local infiltration and distant metastasis. Due to the poor outcomes of OS patients, the study aimed to identify differentially expressed genes (DEGs) in OS and explore their role in the carcinogenesis and progression of OS.MethodsRNA sequencing was performed to identify DEGs in OS. The functions of the DEGs in OS were investigated using bioinformatics analysis, and DEG expression was verified using RT-qPCR and Western blotting. The role of SLC25A4 was evaluated using gene set enrichment analysis (GSEA) and then investigated using functional assays in OS cells.ResultsIn all, 8353 DEGs were screened. GO and KEGG enrichment analyses indicated these DEGs showed strong enrichment in the calcium signaling pathway and pathways in cancer. Moreover, the Kaplan-Meier survival analysis showed ten hub genes were related to the outcomes of OS patients. Both SLC25A4 transcript and protein expression were significantly reduced in OS, and GSEA suggested that SLC25A4 was associated with cell cycle, apoptosis and inflammation. SLC25A4-overexpressing OS cells exhibited suppressed proliferation, migration, invasion and enhanced apoptosis.ConclusionSLC25A4 was found to be significantly downregulated in OS patients, which was associated with poor prognosis. Modulation of SLC25A4 expression levels may be beneficial in OS treatment.

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The diagnosis and treatment of osteosarcoma and Ewing’s sarcoma in children and adolescents

Cited by 6 publications

References 48 publications

The role of lncRNA HCG18 in human diseases

The role of lncRNA HCG18 in human diseases

Trabectedin Enhances Oncolytic Virotherapy by Reducing Barriers to Virus Spread and Cytotoxic Immunity in Preclinical Pediatric Bone Sarcoma

Comprehensive transcriptomic analysis identifies SLC25A4 as a key predictor of prognosis in osteosarcoma

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