A pressure/cross-sectional-area probe was used to describe permanently and adjunctively acting urethral closure forces and urethral deformability at the bladder neck and midurethrally in 30 females with genuine stress incontinence (GSI). The permanent closure forces were described in terms of urethral pressure and elastance and the adjunctive closure forces in terms of power generation during coughing and squeezing. Urethral deformability was assessed from related values of urethral pressure and elastance.Twenty-eight (93%) patients had reduced permanent and/or adjunctive closure forces both at the bladder neck and midurethrally. Various combinations of reduced closure forces were found at the two sites of measurement. Different pathophysiological subgroups could be defined. In the largest group of patients both the permanent and the adjunctive closure forces were reduced. A small group of patients was characterized by decreased urethral deformability. It is concluded that both the bladder neck and mid-urethral sphincter mechanisms are weakened in GSI. The underlying cause is not a single defect in urethral physiology; it is most often the result of weakening of one or more closure mechanisms (intramural and/or extrinsic) and the inability of the other to compensate. The identification of pathophysiologic subgroups may improve the scientific basis for selection of treatment modalities.