The developmental neurobehavioral effects of fenugreek seeds on prenatally exposed mice

Khalki, Loubna; Bennis, Mohamed; Sokar, Zahra; Ba‐M’hamed, Saadia

doi:10.1016/j.jep.2011.12.011

Cited by 25 publications

(21 citation statements)

References 35 publications

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“…At 28 postnatal day age, brain of progeny was examined histologically. The progeny of exposed mice displayed reduced body weight at birth and reduced brain weight, significant decrease in the locomotor activity and motor coordination (Khalki et al, 2012). These results suggest that prenatal exposure of mice to a high dose of fenugreek seeds caused growth retardation and altered neurobehavioral performance in the post-weaning period, though the molecular reasons remain to be determined.…”

Section: Potential Side Effects Of Trigonellamentioning

confidence: 88%

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Pharmacological effects ofTrigonella foenum-graecumL. in health and disease

Yadav

Baquer

2013

Pharmaceutical Biology

215

117

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Context: The health benefits and medicinal properties of herbal food products are known since antiquity. Fenugreek [Trigonella foenum-graecum Linn. (Fabaceae)], a seed spice used to enhance flavor, color and texture of food, is employed for medicinal purposes in many traditional systems. A number of epidemiological studies and laboratory research have unraveled the biological actions of fenugreek. Objective: Research on fenugreek in recent years has identified a number of health benefits and physiological attributes in both experimental animals as well as clinical trials in humans. In this study we have reviewed the available scientific literature on fenugreek. Methods: This review article summarizes and reviews published experimental studies and scientific literature from the databases including PubMed, Google and local library searches. Results: The information available in the literature on the health benefits and pharmaceutical effects of Trigonella accounts for its known medicinal properties and adds new therapeutic effects in newer indications. Besides its known medicinal properties such as carminative, gastric stimulant, antidiabetic and galactogogue (lactation-inducer) effects, newer research has identified hypocholesterolemic, antilipidemia, antioxidant, hepatoprotective, anti-inflammatory, antibacterial, antifungal, antiulcer, antilithigenic, anticarcinogenic and other miscellaneous medicinal effects of fenugreek. Although most of these studies have used whole seed powder or different forms of extracts, some have identified active constituents from seeds and attributed them medicinal values for different indications. Conclusion: The resarch on Trigonella exhibits its health benefits and potential medicinal properties in various indications and has little or no side effects, suggesting its pharmaceutical, therapeutic and nutritional potential.

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Section: Potential Side Effects Of Trigonellamentioning

confidence: 88%

“…The same group examined longer-term neurobehavioral effects in prenatally exposed mice (Khalki et al, 2012). Pregnant females received 0, 500 or 1000 mg/kg/day aqueous extract of fenugreek seed by gavage for the whole period of gestation.…”

Section: Potential Side Effects Of Trigonellamentioning

confidence: 99%

Pharmacological effects ofTrigonella foenum-graecumL. in health and disease

Yadav

Baquer

2013

Pharmaceutical Biology

215

117

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“…Studies on mice showed that lyophilized fenugreek seeds aqueous extract supplementation (500 and 1000 mg/ kg/day) during the whole gestation period decreases the litter size, increases pup mortality, reduces body weights (body weight was measured at postnatal days 1, 7, 14, 21 and 28), and induces malformations (cleft palate formation and a bump on head in newborns), growth retardation, altered neurobehavioral in the post weaning period [17]. Body weight at birth time has shown 27% reduction in the case of 1000 mg/kg treated mothers and 32% in the 500 mg/kg treated group compared with control puppies.…”

Section: Fenugreek (Trigonella Foenum Graecum)mentioning

confidence: 99%

“…Prenatal exposure to the aqueous extract of fenugreek seeds (500 or 1000 mg/kg/day) can also induce a significant decrease in the locomotor activity in both male and female mice, suggesting that aqueous extract of fenugreek seeds induces a depressive effect in the offspring [17].…”

Section: Fenugreek (Trigonella Foenum Graecum)mentioning

confidence: 99%

Herbal laxatives and antiemetics in pregnancy

Samavati

Ducza

Hajagos-Tóth

et al. 2017

Reproductive Toxicology

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a b s t r a c tConstipation appears in the 2nd and 3rd trimester of pregnancy, while nausea is the strongest in the 1st trimester. This review summarizes the applicability of herbal laxatives and antiemetics in pregnancy.A human study has shown that flax oil as laxative is safe from 2nd trimester. Human data is not available about the rhubarb, but animal studies reveal that its emodin content induces fetal abnormalities. Fenugreek induces teratogenic malformation both in human and animals. Senna seed is proved as a safe laxative in pregnancy. The antiemetic ginger is safe during 1st trimester, but it reduces the gestational period when applied from the 2nd trimester. Cannabis induces fetal neurological disorders while fennel can shorten the gestational age.There is herbal alternative for laxative therapy (senna) for the whole length of pregnancy, but nausea and vomiting might be reduced by herbal medicine (ginger) safely in the 1st trimester, only.

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“…Khalki et al (2012Khalki et al ( , 2013 Portanto, apesar de serem necessários novos experimentos utilizando doses maiores da planta para corroborar de forma irrefutável os dados descritos acima, nosso trabalho suporta a ideia de que o uso do fenogrego no período de lactação não representa grande risco para a prole e lactantes.…”

Section: Globulina (G/dl)unclassified

<b>Possível efeito galactagogo e toxicidade da <i>Trigonella foenum-graecum</i> durante o período lactacional. Estudo em ratas</b>

Keller¹

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Possível efeito galactagogo e toxicidade daAutorizo a reprodução parcial ou total desta obra, para fins acadêmicos, desde que citada a fonte. There are different methods used to restore the breast milk production, and one of them is the galactagogues, substances with maternal lactation stimulant properties. DADOS INTERNACIONAIS DE CATALOGAÇÃO-NA-PUBLICAÇÃO(Many of these substances are of vegetable origin, whose use is widely disseminated through popular culture. One of the plants most commonly used is the Trigonella foenum-graecum, popularly known as fenugreek. There are different reports describing the positive effect of fenugreek on maternal lactation; however, there are no systematic studies that support its galactagogue effect. Thus, the purpose of this study was to verify, during lactation, the effect of galactagogue fenogreek and maternal effects and development of offspring rats.To this end, female rats received by gavage different doses of fenugreek's dry seed extract. Our results demonstrate, in the used doses, there is no toxic effect. However, at the tested doses, the treatment also did not stimulate the maternal lactation. Campylobacter enterite (RUIZ-PALACIOS et al., 1990), bem como atuar na redução de doenças autoimunes (MAYER et al., 1988). Ressalta-se ainda que crianças amamentadas têm menor risco de desenvolver enterecolite necrótica, otites, infecções respiratórias, diabetes mellitus e alergias (PULLAN et al., 1980;BORCH-JOHNSEN et al., 1984;MAYER et al., 1988;OKAMOTO;OGRA, 1989;HOWIE et al., 1990;RUIZ-PALACIOS et al., 1990; AVENDANO et al., 1993;NOMMSEN-RIVERS, 1995;RIORDAN, 1997 Apesar das evidências dos diversos benefícios do aleitamento materno e de seu incentivo pelas instituições médicas e de saúde em todo o mundo, muitos fatores contribuem para a diminuição da produção de leite pela mãe e consequentemente o desmame precoce dos filhos. Entre estes fatores estão a falta de conhecimento materno sobre a prática da amamentação que muitas vezes leva a crença de que o leite materno é fraco ou é insuficiente para a nutrição adequada do bebê (MCLEOD; PULLON; COOKSON, 2002) Por outro lado, mães conscientes dos inúmeros benefícios da amamentação mas que apresentam dificuldades para produzir leite suficiente, recorrem a alternativas medicinais, como por exemplo, o uso de galactagogos, que definimos 18 como meio ou substâncias com capacidade de estimular a lactação. Desta forma, estes compostos tornaram-se um importante aliado na produção de leite materno, largamente utilizados em todo o mundo, seja através de recomendação médica ou pela cultura popular. ÍNDICE DE TABELAS GALACTAGOGOSOs galactagogos ou galactogogos podem ser compostos sintéticos, isolados na forma de medicamentos, alimentos ou suplementos a base de plantas. Entre os medicamentos mais comumente prescritos para esta finalidade estão a metoclopramida e a domperidona (BETZOLD, 2004). Estas substâncias agem como antagonistas dopaminérgicos, inibindo a dopamina sobre a secreção de prolactina, ocasionando aumento dos níveis séricos deste h...

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The developmental neurobehavioral effects of fenugreek seeds on prenatally exposed mice

Cited by 25 publications

References 35 publications

Pharmacological effects ofTrigonella foenum-graecumL. in health and disease

Pharmacological effects ofTrigonella foenum-graecumL. in health and disease

Herbal laxatives and antiemetics in pregnancy

<b>Possível efeito galactagogo e toxicidade da <i>Trigonella foenum-graecum</i> durante o período lactacional. Estudo em ratas</b>

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