Herbal laxatives and antiemetics in pregnancy

Samavati, Reza; Ducza, Eszter; Hajagos-Tóth, Judit; Gáspár, Róbert

doi:10.1016/j.reprotox.2017.06.041

Cited by 13 publications

(16 citation statements)

References 45 publications

(54 reference statements)

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“…Perinatal exposure of goats at the early pregnancy caused fetal death and reabsorption. And high dose–induced tissue damage in the mother (vacuolation of liver cells and kidneys) and myocardium bone necrosis (Samavati, Ducza, Hajagos‐Tόth, & Gaspar, 2017).…”

Section: Methodsmentioning

confidence: 99%

“…Aqueous extract of fenugreek was demonstrated to have potential teratogenic effects in humans and animals, and seed consumption during pregnancy has been associated with a range of congenital malformations, including hydrocephalus, anencephaly, and spina bifida. (Khalki, M'hamed, Bennis, Chait, & Sokar, 2010; Samavati et al, 2017). Prenatal exposure of mice to a high dose of fenugreek seeds caused growth retardation and altered neurobehavioral performance in the postweaning period (Khalki, Bennis, Sokar, & Ba‐M'hamed, 2012).…”

Section: Methodsmentioning

confidence: 99%

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Is it safe to consume traditional medicinal plants during pregnancy?

Bernstein

Akram

Yaniv-Bachrach

et al. 2020

Phytotherapy Research

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The popularity of natural medicine is growing worldwide. Unlike conventional licensed medicines, herbal medicine practices are usually not supported by effectiveness, efficacy, or safety studies, which raise concerns about potential risks involved in their usage, particularly in high‐risk patients such as pregnant women where teratogenicity is a concern. Despite a lack of science‐based evidence, the use of herbal products for the management of pregnancy‐associated challenges is common, due to the common notion that they are free of toxic effects and adverse reactions because they are “natural.” The lack of concern about utilizing herbal remedies during pregnancy is strengthened by the lack of regulation in most countries for their marketing. However, plant‐based remedies are not free of adverse reactions. Medicinal plants and herbal remedies contain substances that can be toxic to the human body and the fetus. Potential effects of indiscriminate use of medicinal plants are embryotoxicity, teratogenic, and abortifacient effects. Some plant constituents can cross the placenta and reach the fetus. Phytochemicals and their metabolites are known to induce stimulation of uterine contraction and hormone imbalance that could result in abortion. The alterations to the hormonal profile can affect conception, induce teratogenic activity, and halt the pregnancy or produce a congenital malformation. Due to the wide range of modes of action of phytochemicals, some medicinal plants may be safe to use during certain trimesters of pregnancy and harmful at other stages. This manuscript reviews available scientific information concerning potential health hazards associated with the consumption of herbal medicines during pregnancy, highlighting those herbs that should be avoided due to their potential abortifacient and/or teratogenic activity. We focused on plants that were tested by preclinical studies, and studies of these plants are summarized. Common therapeutic use of these herbs, estimated effects, toxicological effects, and animal studies of these plants is summarized. The literature reviewed suggests that consumption of the following medicinal plants should be avoided during pregnancy: Abrus precatorius, Achyranthes aspera, Ailanthus excelsa, Aloe vera, Aristolochia indica, Areca catechu, Bambusa vulgaris, Cassia occidentalis, Cicer arietinum, Cimicifuga racemose, Dolichandrone falcate, Ginkgo biloba, Hydrastis canadensis, Indigofera trifoliate, Lavandula latifolia, Maytenus ilicifolia, Momordica cymbalaria, Moringa oleifera, Musa rosacea, Oxalis corniculate, Phytolacca dodecandra, Plumeria rubra, Ricinus communis, Ruta graveolens, Stachys lavandulifolia, Senna alata, Trigonella foenum‐graecum, Vitus agnus‐castus, and Valeriana officinalis.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Is it safe to consume traditional medicinal plants during pregnancy?

Bernstein

Akram

Yaniv-Bachrach

et al. 2020

Phytotherapy Research

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“…Again, these findings were consistent with those reported in a previous study in which pregnant women and gynecologists agreed that the risks of abortion associated with using ginger for nausea and vomiting of pregnancy should be addressed during clinical consultations [ 15 ]. Previous studies showed that aqueous extract of fenugreek had potential teratogenic effects in humans and animals [ 33 , 39 ]. Health regulatory bodies tend to recommend avoidance of herbal remedies even when the risks associated with their use are inconclusive.…”

Section: Discussionmentioning

confidence: 99%

“…Many breastfeeding women could be asthmatics and should be warned of this potential harm of using fenugreek. Again, breastfeeding women should be warned that fenugreek could cause nausea and vomiting which could be disturbing to the breastfeeding women and could have negative effects on their reported quality of life [ 39 ]. Fenugreek could be associated with diarrhea and excessive sweating for the breastfeeding women and their breastfed infants [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Which Benefits and Harms of Using Fenugreek as a Galactogogue Need to Be Discussed during Clinical Consultations? A Delphi Study among Breastfeeding Women, Gynecologists, Pediatricians, Family Physicians, Lactation Consultants, and Pharmacists

Shawahna

Qiblawi

Ghanayem

2018

Evidence-Based Complementary and Alternative Medicine

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Background Breastfeeding women with hypogalactia are commonly recommended to use fenugreek as a galactogogue. This study aimed to achieve formal consensus among breastfeeding women and healthcare providers on which potential harms and benefits of using fenugreek need to be communicated and discussed during clinical consultations. Methods A two-iterative round Delphi technique was used in two separate panels of breastfeeding women (n = 65) and healthcare providers (n = 56) to achieve formal consensus on a list of 24 and 16 items related to potential harms and benefits of fenugreek. Results About 70% of the healthcare providers recommended quite often herbal remedies for breastfeeding women and about 68% of the women had been recommended to use herbal remedies many times by their healthcare providers. Consensus was achieved on 21 potential harms and 14 potential benefits of using fenugreek to enhance human milk supply that need to be discussed with breastfeeding women during consultations. Conclusion Probably, potential harms and benefits of recommending fenugreek as herbal galactogogue for breastfeeding women seeking recommendations to increase their human milk supply need to be discussed during clinical consultations. Further observational studies are needed to assess what is being discussed in daily consultations when herbal remedies are recommended.

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“…The consumption of fenugreek ( Trigonella foenum graecum ) in pregnancy may induce congenital malformations and death [133,134]. In male rats, mice, and rabbits, fenugreek may induce testicular toxicity and anti-fertility effects, while it alters fertility, implantation, and abortions in females [134].…”

Section: Development: Pregnancy Lactation and Developmental Trajmentioning

confidence: 99%

The Sex–Gender Effects in the Road to Tailored Botanicals

Campesi

Romani

Franconi³

2019

Nutrients

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Phenols are a wide family of phytochemicals that are characterized by large chemical diversity and are considered to bioactive molecules of foods, beverages, and botanicals. Although they have a multitude of biological actions, their beneficial effects are rarely evidenced in clinical practice. This may occur due to the presence of numerous confounders, such as the modulation of phenol bioavailability, which can be regulated by microbiota, age, sex-gender. Sex-gender is an important determinant of health and well-being, and has an impact on environmental and occupational risks, access to health care, disease prevalence, and treatment outcomes. In addition, xenobiotic responses may be strongly influenced by sex-gender. This review describes how sex–gender differentially influences the activities of phenols also in some critical periods of women life such as pregnancy and lactation, considering also the sex of fetuses and infants. Thus, sex–gender is a variable that must be carefully considered and should be used to propose directions for future research on the road to tailored medicine and nutrition.

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Herbal laxatives and antiemetics in pregnancy

Cited by 13 publications

References 45 publications

Is it safe to consume traditional medicinal plants during pregnancy?

Is it safe to consume traditional medicinal plants during pregnancy?

Which Benefits and Harms of Using Fenugreek as a Galactogogue Need to Be Discussed during Clinical Consultations? A Delphi Study among Breastfeeding Women, Gynecologists, Pediatricians, Family Physicians, Lactation Consultants, and Pharmacists

The Sex–Gender Effects in the Road to Tailored Botanicals

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